Qian Wang, Benn Sartorius, Nicholas Philip John Day, Richard James Maude
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引用次数: 0
摘要
背景：恙虫病是一种被忽视的威胁生命的病媒传染病，主要由恙虫病东方杆菌引起，偶尔会在幼螨取食时传染给人类。据估计，全世界每年有超过 10 亿人受到潜在威胁，每年有 100 万例临床病例发生；然而，目前尚不清楚这一估计数字是如何计算出来的（也不清楚最初的来源是什么），而且关于该疾病的全球负担和风险因素仍有许多未知数。本系统综述旨在全面概述恙虫病在全球、国家和国家以下各级的时空分布情况、相关负担和风险因素，并回顾在这些不同范围内使用的负担估算模型：方法：将对有关恙虫病发生、风险因素和建模方法的文献进行系统检索。将在 PubMed 和其他五个数据库中搜索已发表的文献，并使用 Google Scholar 和其他九个数据库搜索灰色文献。所有检索记录的标题/摘要将由两名审稿人分别评估，然后由他们筛选潜在记录的全文，以决定是否符合条件。一位评审员将使用预先格式化的电子表格从合格的研究中提取数据，并由第二位评审员检查结果。针对每个综述问题，将对数据进行制表、描述性综合和叙述性总结。在适当的情况下，将进行荟萃分析。将对偏倚风险进行评估，并检测潜在的发表偏倚：本综述将提供对当前恙虫病的发生、时空分布和负担的全面了解，确定从全球到国家以下各级的相关风险因素，整合最佳实践建模框架以估算不同地理/时空分辨率下的恙虫病负担，并分解各种风险因素在规模上的相对贡献：CRD42022315209。
Spatio-temporal occurrence, burden, risk factors and modelling methods for estimating scrub typhus burden from global to subnational resolutions: a systematic review protocol.
Background: Scrub typhus is a neglected life-threatening vector-borne disease mainly caused by the bacterium Orientia tsutsugamushi, which is occasionally transmitted to humans during feeding of larval mites. It has been estimated that more than 1 billion persons are potentially threatened and 1 million clinical cases occur annually across the world; however, it is unclear how this estimate was computed (and what the original source was) and much remains unknown regarding its global burden and risk factors. This systematic review aims to provide a comprehensive overview of the spatial-temporal distribution of scrub typhus, associated burden and risk factors at global, national and subnational resolutions, and to review the burden estimation models used at those different scales.
Methods: A systematic search for literature on scrub typhus occurrence, risk factors and modelling methods will be conducted. PubMed and five other databases will be searched for published literature, and Google Scholar and nine other databases will be used to search for grey literatures. All titles/abstracts of the searched records will be separately assessed by two reviewers, who will then screen the full-text of potential records to decide eligibility. A pre-formatted spreadsheet will be used by one reviewer to extract data from qualifying research, with a second reviewer checking the results. Data will be tabulated, synthesized descriptively, and summarized narratively for each review question. Where appropriate, meta-analyses will be conducted. The risk of bias will be assessed, and potential publication bias will be detected.
Discussion: This review will provide a comprehensive understanding of the current occurrence, spatial-temporal distribution, and burden of scrub typhus, identify associated risk factors from global to subnational resolutions, consolidate the best practice modeling framework(s) to estimate the burden of scrub typhus at various geographic/temporal resolutions, and decompose the relative contributions of various risk factors at scale.
Wellcome Open ResearchBiochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
5.50
自引率
0.00%
发文量
426
审稿时长
1 weeks
期刊介绍：
Wellcome Open Research publishes scholarly articles reporting any basic scientific, translational and clinical research that has been funded (or co-funded) by Wellcome. Each publication must have at least one author who has been, or still is, a recipient of a Wellcome grant. Articles must be original (not duplications). All research, including clinical trials, systematic reviews, software tools, method articles, and many others, is welcome and will be published irrespective of the perceived level of interest or novelty; confirmatory and negative results, as well as null studies are all suitable. See the full list of article types here. All articles are published using a fully transparent, author-driven model: the authors are solely responsible for the content of their article. Invited peer review takes place openly after publication, and the authors play a crucial role in ensuring that the article is peer-reviewed by independent experts in a timely manner. Articles that pass peer review will be indexed in PubMed and elsewhere. Wellcome Open Research is an Open Research platform: all articles are published open access; the publishing and peer-review processes are fully transparent; and authors are asked to include detailed descriptions of methods and to provide full and easy access to source data underlying the results to improve reproducibility.
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