对羟基苯甲酸酯这把双刃剑:了解它的益处和潜在的健康风险。

IF 8.2 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Science of the Total Environment Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI:10.1016/j.scitotenv.2024.176547
Sovona Chatterjee, Satadal Adhikary, Suchandra Bhattacharya, Aritra Chakraborty, Sohini Dutta, Dipsikha Roy, Abhratanu Ganguly, Sayantani Nanda, Prem Rajak
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引用次数: 0

摘要

对羟基苯甲酸酯作为重要的防腐剂被广泛应用于全球的药品、食品和个人护理产品中。然而,不当处置含有对羟基苯甲酸酯的商业产品可能会污染各种环境成分,包括土壤和水。在地表水、地下水、包装食品材料和其他消费品中都检测到了对羟基苯甲酸酯的残留。通过大量消费品和受污染的水长期接触对羟基苯甲酸酯会损害人体健康。对羟基苯甲酸酯可调节人体的荷尔蒙和免疫系统。最近的研究结果表明,使用对羟基苯甲酸酯与过敏、肥胖和不孕症有关。值得注意的是,在乳腺癌患者的样本中也检测到了对羟基苯甲酸酯,这表明对羟基苯甲酸酯与致癌之间可能存在交叉作用。因此,本文旨在剖析对羟基苯甲酸酯作为防腐剂在几种消费品中的重要作用及其长期接触对人体健康的影响。这篇综述涵盖了对羟基苯甲酸酯的各个方面,包括其来源、分子水平的作用机制,并揭示了其对人类健康的毒理学影响。
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Parabens as the double-edged sword: Understanding the benefits and potential health risks.

Parabens are globally employed as important preservatives in pharmaceutical, food, and personal care products. Nonetheless, improper disposal of commercial products comprising parabens can potentially contaminate various environmental components, including the soil and water. Residues of parabens have been detected in surface water, ground water, packaged food materials, and other consumer items. Long-term exposure to parabens through numerous consumer products and contaminated water can harm human health. Paraben can modulate the hormonal and immune orchestra of the body. Recent findings have correlated paraben use with hypersensitivity, obesity, and infertility. Notably, parabens have also been detected in the samples of breast cancer patients, suggesting a potential cross-talk between parabens and carcinogenesis. Therefore, the present article aims to dissect the significance of parabens as a preservative in several consumer products and their impact of chronic exposure to human health. This review encompasses various facets of paraben, including its sources, mechanism of action at the molecular level, and sheds light on its toxicological implications on human health.

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来源期刊
Science of the Total Environment
Science of the Total Environment 环境科学-环境科学
CiteScore
17.60
自引率
10.20%
发文量
8726
审稿时长
2.4 months
期刊介绍: The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.
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