一名接受左氧氟沙星治疗的 HLA-B*1502 患者出现中毒性表皮坏死症。

IF 3.2 4区医学 Q2 PHARMACOLOGY & PHARMACY Clinical therapeutics Pub Date : 2024-09-30 DOI:10.1016/j.clinthera.2024.09.014

Xiufang Wang, Gangying Cheng, Xiaofang Liang, Junhui Yang, Aiping Deng, Dan Chen, Chao Liu, Ying Gao, Juyi Li

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引用次数: 0

摘要

目的：探讨HLA-B基因突变与左氧氟沙星诱发的中毒性表皮坏死（TEN）之间的关系：一名 71 岁的中国女性因膀胱炎口服索利那新（5 毫克）和左氧氟沙星（0.5 克）后出现 TEN。使用实时 PCR 检测了 HLA-B*5801 和 HLA-B*1502 等位基因：经过支持治疗（抗过敏治疗、血浆置换等）和停用罪魁祸首药物左氧氟沙星后，患者出院时脱落的皮肤重新上皮。患者 HLA-B*1502 等位基因阳性，HLA-B*5801 等位基因阴性：这是首例怀疑由 HLA-B*1502 等位基因突变引起的左氧氟沙星诱发 TEN 的报告。

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Toxic Epidermal Necrolysis Observed in a Patient With the HLA-B*1502 Treated With Levofloxacin.

Purpose: To determine the relationship between HLA-B gene mutations and levofloxacin-induced toxic epidermal necrolysis (TEN).

Methods: A 71-year-old Chinese woman developed TEN after oral administration of solifenacin (5 mg) and levofloxacin (0.5 g) for cystitis. HLA-B*5801 and HLA-B*1502 alleles were detected using real-time PCR.

Findings: After supportive therapy (antiallergic treatments, plasma exchange, etc) and withdrawal of the culprit medication levofloxacin, the patient was discharged with re-epithelialization of the exfoliated skin. The patient was HLA-B*1502 allele positive and HLA-B*5801 allele negative.

Implications: This is the first report of levofloxacin-induced TEN suspected to be caused by mutations in the HLA-B*1502 allele.

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来源期刊

Clinical therapeutics 医学-药学

CiteScore

6.00

自引率

3.10%

发文量

154

审稿时长

9 weeks

期刊介绍： Clinical Therapeutics provides peer-reviewed, rapid publication of recent developments in drug and other therapies as well as in diagnostics, pharmacoeconomics, health policy, treatment outcomes, and innovations in drug and biologics research. In addition Clinical Therapeutics features updates on specific topics collated by expert Topic Editors. Clinical Therapeutics is read by a large international audience of scientists and clinicians in a variety of research, academic, and clinical practice settings. Articles are indexed by all major biomedical abstracting databases.