心率对脉搏传输时间和收缩压之间关系的影响。

IF 2.3 4区医学 Q3 BIOPHYSICS Physiological measurement Pub Date : 2024-10-02 DOI:10.1088/1361-6579/ad8299

Zhizhong Fu, Xinyue Song, Tianyi Qin, Yifan Chen, Xiaorong Ding

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引用次数: 0

摘要

目的：脉搏转运时间（PTT）是血压（BP）变化的常用指标。然而，PTT 和 BP 之间的关系在某种程度上取决于个体，导致基于 PTT 的 BP 估算不准确。PTT 和 BP 的干扰因素（如心率）可能是主要原因。在本研究中，我们试图将心率作为一个窗口，探讨混杂因素对 PTT 和 BP 关系的影响：方法：我们通过引入异质性治疗效果（HTE）作为定量指标，研究了不同心率水平下 PTT 与收缩压（SBP）之间的关系。与使用传统指标（如回归系数、相关系数）计算平均心率相比，HTE计算方法可以计算不同心率水平下PTT与SBP之间的关系，并减少混杂因素的影响：我们分析了 47 名静息健康年轻人在不同 HR 水平下 PTT 和 SBP 的 HTE。结果显示，PTT 和 SBP 的 HTE 强度随心率的变化而变化，这表明 PTT 和 SBP 之间因果关系的强度受心率水平的影响。而 SBP 与 PTT 之间的相关性取决于个体；相关性的强度或方向可随心率变化而变化。我们进一步调查了 PTT 和 SBP 呈负相关的一组受试者，发现约 50%的受试者在心率增加时 HTE 强度增强，而其余受试者则相反：本研究表明，在使用 PTT 作为 SBP 的指标时，需要考虑心率。

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The influence of heart rate on the relationship between pulse transit time and systolic blood pressure.

Objective: Pulse transit time (PTT) is a popular indicator of blood pressure (BP) changes. However, the relationship between PTT and BP is somehow individual dependent, resulting in the inaccuracy of PTT-based BP estimation. Confounding factors, e.g., heart rate (HR), of PTT and BP could be the primary cause. In this study we attempt to explore the impact of HR as a window to look at the influence of confounding factors on the relationship between PTT and BP.

Approach: We investigated the relationship between PTT and systolic BP (SBP) at different HR levels by introducing the heterogeneous treatment effects (HTE) as a quantitative indicator. Compared to the average HR calculated using traditional indicators (e. g. regression coefficient, correlation coefficient), the HTE calculation method can compute the relationship between PTT and SBP at different HR levels, and reduce the influence of confounding factors.

Main results: We analyzed the HTE of PTT and SBP of 47 subjects who are resting healthy young people with varying levels of HR. The results showed that the strength of the HTE of PTT and SBP varied with HR, indicating that the strength of the causal relationship between PTT and SBP is subject to HR levels. Whereas the correlation between SBP and PTT was individual dependent; either the strength or the direction of the correlation can vary with HR. We further investigated the group in which PTT and SBP exhibited a negative correlation, and found that about 50% of the subjects showed enhanced strength of HTE in with an increase in HR and the remaining showed the opposite.

Significance: This study means that HR needs to be considered when PTT is used as an indicator of SBP.

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来源期刊

Physiological measurement 生物-工程：生物医学

CiteScore

5.50

自引率

9.40%

发文量

124

审稿时长

3 months

期刊介绍： Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation. Papers are published on topics including: applied physiology in illness and health electrical bioimpedance, optical and acoustic measurement techniques advanced methods of time series and other data analysis biomedical and clinical engineering in-patient and ambulatory monitoring point-of-care technologies novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems. measurements in molecular, cellular and organ physiology and electrophysiology physiological modeling and simulation novel biomedical sensors, instruments, devices and systems measurement standards and guidelines.