光生物调节对完全性脊髓损伤伴骨质疏松症患者的骨矿物质密度、血清维生素 D 和骨形成标志物的影响。

IF 1.8 Q2 SURGERY Photobiomodulation, photomedicine, and laser surgery Pub Date : 2024-11-01 Epub Date: 2024-10-02 DOI:10.1089/photob.2023.0195
Esmaeil Mohammadzadeh, Aref Hosseinian Amiri, Reza Fekrazad, Rainer A Leitgeb, Winfried Mayr, Kamran Ezzati
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引用次数: 0

摘要

研究设计:准实验研究采用配对设计,在身体一侧的四个部位进行光生物调节,并在另一侧的相应部位进行对照。研究目的本研究旨在评估光生物调节治疗对完全性脊髓损伤(C.SCI)和骨质疏松症患者使用双能 X 射线吸收测量法测量骨矿密度(BMD)的影响。治疗方法八名患者接受了四个部位的治疗:前臂-中远端(MID)、近端-股骨、远端-股骨和近端-胫骨,共 32 个部位。使用 830 纳米镓铝砷化半导体激光器进行照射,每周三次,持续 8 周。根据超声波检查评估的距皮肤表面的骨深度确定不同的剂量(能量密度),并通过照射时间将深度为 1.5 厘米的骨深度分别调整为 8、10 和 12 J/cm2,使用 200 mW 功率在每个治疗部位的每个骨深度提供最佳等剂量激光。在基线、治疗第 8 周和随访第 15 周时测量 BMD。血清 25-(OH)-vitamin D 和骨形成标志物(包括骨钙素和骨碱性磷酸酶 (B-ALP))也在基线和治疗第 8 周时进行了评估。结果显示在治疗第 8 周和第 15 周时,近端-女性和前臂-MID 的 BMD 均有显著增加。治疗后,血清 25-(OH)-vitamin D 水平显著增加。但是,远端-股骨和近端-胫骨的 BMD 以及骨钙素和 B-ALP 水平均未出现明显变化。结论光生物调节(830 nm)激光在改善 C.SCI 患者的近端-股骨和前臂-MID 的 BMD 方面具有疗效。此外,观察到的对维生素 D 水平的积极影响表明,光生物调节具有潜在的作用,值得进一步研究。
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The Effect of Photobiomodulation on Bone Mineral Density, Serum Vitamin D, and Bone Formation Markers in Individuals with Complete Spinal Cord Injuries with Osteoporosis.

Study design: A quasi-experimental study utilized a matched-pair design, administering photobiomodulation at four-sites on one side of the body and assigning control to the other side at corresponding sites. Objectives: This study aimed to assess photobiomodulation treatment effects on bone mineral density (BMD) measurement using dual-energy X-ray-absorptiometry in individuals with complete spinal cord injury (C.SCI) and osteoporosis. Methods: Eight patients received treatment at four-sites: forearm-mid-distal (MID), proximal-femur, distal-femur, and proximal-tibia, totaling 32 sites. Using an 830 nm gallium-aluminum-arsenide semiconductor laser irradiation was administered three times weekly for 8 weeks. Different doses (energy density) were determined depending on bone depth from skin surface, as assessed by sonography and adjusted through irradiation time to be 8, 10, and 12 J/cm2 for depths <1 cm, between 1 and 1.5 cm, and >1.5 cm, respectively, using 200 mW power to deliver the optimal isodose of laser at each depth of bone within each therapeutic site. BMD was measured at baseline, week 8 of treatment, and week 15 of follow-up. Serum 25-(OH)-vitamin D and bone formation markers including osteocalcin and bone-alkaline-phosphatase (B-ALP) were also assessed at baseline and week 8 of treatment. Results: Significant increases in BMD were noted in proximal-femur and forearm-MID at both week 8 and week 15. Serum 25-(OH)-vitamin D levels significantly increased after treatment. However, no notable changes were observed in distal-femur and proximal-tibia BMD or in osteocalcin and B-ALP levels. Conclusions: Photobiomodulation (830 nm) laser demonstrated efficacy in improving BMD at proximal-femur and forearm-MID in individuals with C.SCI. Moreover, the observed positive influence on vitamin D levels suggests a potential photobiomodulation role, warranting further investigation.

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来源期刊
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期刊介绍: Photobiomodulation, Photomedicine, and Laser Surgery Editor-in-Chief: Michael R Hamblin, PhD Co-Editor-in-Chief: Heidi Abrahamse, PhD
期刊最新文献
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