转录因子 KROX20 标志着上皮干细胞的毛囊形成。

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Journal of Clinical Investigation Pub Date : 2024-10-03 DOI:10.1172/JCI180160
Elnaz Ghotbi, Edem Tchegnon, Zhiguo Chen, Stephen Li, Tracey Shipman, Yong Wang, Jenny Raman, Yumeng Zhang, Renee M McKay, Chung-Ping Liao, Lu Q Le
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引用次数: 0

摘要

表皮干细胞控制着皮肤和毛发的平衡与再生。在哺乳动物的毛囊隆起区,缓慢循环的干细胞群在周期性的生长期(生长)、休止期(静止)和衰退期(衰退)中再生毛囊隆起区。多能表皮细胞也存在于隆起区上方的高频,有助于皮脂腺和高频中上部的形成和维持。在这里,我们报告了转录因子Krox20在位于HF中上部的表皮干细胞群中的富集情况。使用诱导性Krox20-CreERT进行的表达分析和系谱追踪显示,Krox20系细胞迁移出这一HF区域,促进了HF中隆起的形成,成为隆起干细胞的祖先。体内去除了这些细胞,高频形态发生就会停止。这项研究为毛发稳态不可或缺的表皮干细胞群确定了一种新的标记。
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Transcription factor KROX20 marks epithelial stem cells for hair follicle formation.

Epidermal stem cells control homeostasis and regeneration of skin and hair. In the hair follicle (HF) bulge of mammals, populations of slow-cycling stem cells regenerate the HF during cyclical rounds of anagen (growth), telogen (quiescence), and catagen (regression). Multipotent epidermal cells are also present in the HF above the bulge area, contributing to the formation and maintenance of sebaceous gland and upper and middle portions of the HF. Here, we report that the transcription factor Krox20 is enriched in an epidermal stem cell population located in the upper/ middle HF. Expression analyses and lineage tracing using inducible Krox20-CreERT showed that Krox20-lineage cells migrate out of this HF region and contribute to the formation of bulge in the HF, serving as ancestors of bulge stem cells. In vivo depletion of these cells arrests HF morphogenesis. This study identifies a novel marker for an epidermal stem cell population that is indispensable for hair homeostasis.

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来源期刊
Journal of Clinical Investigation
Journal of Clinical Investigation 医学-医学:研究与实验
CiteScore
24.50
自引率
1.30%
发文量
1034
审稿时长
2 months
期刊介绍: The Journal of Clinical Investigation, established in 1924 by the ASCI, is a prestigious publication that focuses on breakthroughs in basic and clinical biomedical science, with the goal of advancing the field of medicine. With an impressive Impact Factor of 15.9 in 2022, it is recognized as one of the leading journals in the "Medicine, Research & Experimental" category of the Web of Science. The journal attracts a diverse readership from various medical disciplines and sectors. It publishes a wide range of research articles encompassing all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others. The Editorial Board consists of esteemed academic editors who possess extensive expertise in their respective fields. They are actively involved in research, ensuring the journal's high standards of publication and scientific rigor.
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