新加坡孕妇巨细胞病毒血清流行率。

IF 3.6 Q1 TROPICAL MEDICINE Tropical Medicine and Health Pub Date : 2024-10-03 DOI:10.1186/s41182-024-00634-z
Pamela Partana, Wei Yee Wan, Xin Yu Venessa Chow, Jerry Kok Yen Chan, Lay Kok Tan, Wei Ching Tan, Piea Peng Lee, Gek Hsiang Lim, Liying Yang
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引用次数: 0

摘要

背景:巨细胞病毒(CMV巨细胞病毒(CMV)是孕期最常见的先天性感染,对胎儿有潜在的长期不良影响。有关新加坡孕妇 CMV 血清流行率的数据很有限,上一次报告的研究要追溯到二十多年前。我们研究了新加坡产前人群中最新的 CMV 血清流行率:方法:2021 年 1 月至 2021 年 8 月期间,我们随机抽取了 385 名在新加坡中央医院接受产前检查的孕妇,对她们在怀孕前三个月采集的血液样本进行 CMV IgG 检测。CMV IgG 阳性代表怀孕前曾接触过 CMV:结果:CMV 血清阳性率为 71.7%(276/385)(95% CI 067,0.76,P 值 结论:CMV 血清阳性率呈下降趋势:新加坡孕妇的 CMV 血清阳性率呈下降趋势,这表明该人群中有相当一部分人在怀孕期间面临原发性母体 CMV 感染的风险。新的研究表明,使用伐昔洛韦进行产前治疗可有效降低垂直传播的可能性。考虑到这一证据,当务之急是重新评估关于在孕期普遍进行母体巨细胞病毒筛查的建议。
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Seroprevalence of cytomegalovirus among pregnant women in Singapore.

Background: Cytomegalovirus (CMV) is the most common congenital infection in pregnancy with potential long-term adverse effects on the fetus. There is limited data on CMV seroprevalence in pregnant women in Singapore, with last reported study dating back over two decades. We look at the latest CMV seroprevalence in antenatal population in Singapore.

Methods: Between January 2021 and August 2021, 385 pregnant women receiving antenatal care at Singapore General Hospital were randomly selected for CMV IgG test to be performed on their blood samples collected during the first trimester of their pregnancies. Positivity for CMV IgG represents past exposure prior to pregnancy.

Results: Overall CMV seroprevalence was 71.7% (276/385) (95% CI 067, 0.76, p value < 0.001). The trend of CMV IgG positivity increased with age, 68.3% (95% CI 0.60, 0.76, p value < 0.001) in those aged 20-29, 72.5% (95% CI 0.66, 0.78, p value < 0.001) in the 30-39 age group, and 79.0% (95% CI 0.67, 0.76, p value 0.012) in women over 40.

Conclusions: There is a declining trend in CMV seroprevalence among pregnant women in Singapore, which indicates that a substantial portion of this population faces the risk of primary maternal CMV infection during pregnancy. Emerging research suggests that prenatal treatment with valacyclovir effectively reduces the likelihood of vertical transmission. Considering this evidence, it is imperative to reevaluate the recommendations for universal maternal CMV screening during pregnancy.

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来源期刊
Tropical Medicine and Health
Tropical Medicine and Health TROPICAL MEDICINE-
CiteScore
7.00
自引率
2.20%
发文量
90
审稿时长
11 weeks
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