Synthesis and Characterization of a Chemico-structurally Modified Bis-GMA Analog for Dental Applications.

Aim: This study aimed to synthesize and characterize a novel Bis-GMA analog, termed P-Bis-GMA, through structural modification by replacing hydroxyl (-OH) groups with phosphonooxy [-O-P(=O)(OH)₂] groups and to evaluate and compare its viscosity with Bis-GMA.

Materials and methods: Bis-GMA, triethylamine, dichloromethane, and phosphoryl chloride were utilized for the synthesis of P-Bis-GMA through phosphorylation. Fourier discerned the chemical structure of the synthesized P-Bis-GMA transform infrared spectroscopy (FTIR), and its viscosity was assessed by rheometry in oscillatory shear mode over a frequency sweep range of 0.1-100 (ω, rad/s) at 25°C with a 25 mm parallel plate design and a 0.5 mm gap. The data was recorded and statistically analyzed.

Results: The FTIR analysis confirmed the successful synthesis of P-Bis-GMA, evidenced by the disappearance of hydroxyl (-OH) peaks and the emergence of phosphonooxy [-O-P(=O)(OH)₂] peaks in the P-Bis-GMA. Rheological testing demonstrated a notable reduction in viscosity for P-Bis-GMA (436.62 Pa.s) when compared to conventional Bis-GMA (1089.02 Pa.s), indicating improved handling characteristics.

Conclusion: P-Bis-GMA was successfully synthesized by phosphorylation reaction where the -OH groups responsible for the high viscosity in the Bis-GMA were replaced with the [-O-P(=O)(OH)₂] groups with significantly reduced viscosity.

Clinical significance: The development of P-Bis-GMA holds promise for simplifying dental procedures by reducing chairside time with uncooperative children. The P-Bis-GMA-based composites possess self-adhering properties thereby eschewing the etching and bonding procedures with reduced moisture contamination of the restoration during bonding. This ultimately leads to better clinical outcomes and improved patient experiences by reducing technical vulnerabilities. How to cite this article: Ajay R, Selvabalaji A, Muthamilselvi M, et al. Synthesis and Characterization of a Chemico-structurally Modified Bis-GMA Analog for Dental Applications. J Contemp Dent Pract 2024;25(6):588-592.