Wenyue Li, Junwei Cheng, Chuang Liu, Ni Zhang, Hua Lin, Fangfei He, Zhihua Gan, Peisen Zhang, Meng Qin, Yi Hou
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Because of the longer tumbling time (τ <jats:sub>R</jats:sub> ), NaGdF <jats:sub>4</jats:sub> nanoparticles can improve the longitudinal relaxivity ( <jats:italic>r</jats:italic> <jats:sub>1</jats:sub> ), brightening vessels in <jats:italic>T</jats:italic> <jats:sub>1</jats:sub> -weighted sequences. Simultaneously, the regular arrangement of Gd <jats:sup>3+</jats:sup> in the crystal induces magnetic anisotropy, creating local static magnetic field heterogeneity and generating negative signals in <jats:italic>T</jats:italic> <jats:sub>2</jats:sub> -weighted sequences. Consequently, the efficacy of NaGdF <jats:sub>4</jats:sub> -enhanced high-resolution multiparameter MRA has been validated in diagnosing ischemic stroke and Alzheimer’s disease in rodent models. In addition, the dual-contrast imaging has been realized on swine with a clinical 3.0-T magnetic resonance imaging scanner, highly emphasizing the clinical translation prospect.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":null,"pages":null},"PeriodicalIF":11.7000,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Shine and darkle the blood vessels: Multiparameter hypersensitive MR angiography for diagnosis of panvascular diseases\",\"authors\":\"Wenyue Li, Junwei Cheng, Chuang Liu, Ni Zhang, Hua Lin, Fangfei He, Zhihua Gan, Peisen Zhang, Meng Qin, Yi Hou\",\"doi\":\"10.1126/sciadv.adq4082\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Magnetic resonance angiography (MRA) is pivotal for diagnosing panvascular diseases. However, single-modality MRA falls short in diagnosing diverse vascular abnormalities. 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引用次数: 0
摘要
磁共振血管造影术(MRA)是诊断全血管疾病的关键。然而,单一模式的 MRA 无法诊断各种血管异常。因此,人们正在寻找兼具 T 1 和 T 2 效应的造影剂,用于多参数 MRA,以获得临床应用前景,但如何平衡 T 1 和 T 2 造影剂的增强效应仍是一项科学挑战。在此,我们利用双模态 NaGdF 4 纳米粒子开发了一种高灵敏度多参数 MRA 策略。由于翻滚时间(τ R)较长,NaGdF 4 纳米粒子可提高纵向弛豫度(r 1),从而在 T 1 加权序列中增亮血管。同时,Gd 3+ 在晶体中的规则排列会引起磁各向异性,产生局部静态磁场异质性,在 T 2 加权序列中产生负信号。因此,NaGdF 4 增强型高分辨率多参数 MRA 在啮齿动物模型中诊断缺血性中风和阿尔茨海默病的疗效已得到验证。此外,还利用临床 3.0-T 磁共振成像扫描仪在猪身上实现了双对比成像,极大地拓展了临床应用前景。
Shine and darkle the blood vessels: Multiparameter hypersensitive MR angiography for diagnosis of panvascular diseases
Magnetic resonance angiography (MRA) is pivotal for diagnosing panvascular diseases. However, single-modality MRA falls short in diagnosing diverse vascular abnormalities. Thus, contrast agents combining T1 and T2 effects are sought for multiparameter MRA with clinical promise, yet achieving a balance in T1 and T2 contrast enhancement effects remains a scientific challenge. Herein, we developed a hypersensitive multiparameter MRA strategy using dual-modality NaGdF 4 nanoparticles. Because of the longer tumbling time (τ R ), NaGdF 4 nanoparticles can improve the longitudinal relaxivity ( r1 ), brightening vessels in T1 -weighted sequences. Simultaneously, the regular arrangement of Gd 3+ in the crystal induces magnetic anisotropy, creating local static magnetic field heterogeneity and generating negative signals in T2 -weighted sequences. Consequently, the efficacy of NaGdF 4 -enhanced high-resolution multiparameter MRA has been validated in diagnosing ischemic stroke and Alzheimer’s disease in rodent models. In addition, the dual-contrast imaging has been realized on swine with a clinical 3.0-T magnetic resonance imaging scanner, highly emphasizing the clinical translation prospect.
期刊介绍:
Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.