关于使用体外膜氧合的成年重症患者抗菌药物剂量的叙述性综述。

IF 8.8 1区医学 Q1 CRITICAL CARE MEDICINE Critical Care Pub Date : 2024-10-04 DOI:10.1186/s13054-024-05101-z

Myeongji Kim, Maryam Mahmood, Lynn L Estes, John W Wilson, Nathaniel J Martin, Joseph E Marcus, Ankit Mittal, Casey R O'Connell, Aditya Shah

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引用次数: 0

摘要

在接受体外膜氧合（ECMO）的重症患者中，抗菌药物的最佳剂量策略尚不清楚。我们就 ECMO 对抗菌药物（包括重症患者常用的抗菌药、抗真菌药和抗病毒药）的药代动力学和药效学的影响对现有文献进行了全面回顾。我们旨在为临床医生提供有关这些患者经验性用药策略的实用指导。最后，我们将讨论治疗药物监测的重要性、现有文献的局限性以及未来的研究方向。

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A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation.

The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.

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来源期刊

Critical Care 医学-危重病医学

CiteScore

20.60

自引率

3.30%

发文量

348

审稿时长

1.5 months

期刊介绍： Critical Care is an esteemed international medical journal that undergoes a rigorous peer-review process to maintain its high quality standards. Its primary objective is to enhance the healthcare services offered to critically ill patients. To achieve this, the journal focuses on gathering, exchanging, disseminating, and endorsing evidence-based information that is highly relevant to intensivists. By doing so, Critical Care seeks to provide a thorough and inclusive examination of the intensive care field.