Critical Care最新文献

{"title":"Analytical performance of species-targeted quantitative PCR for intra-abdominal candidiasis in critically ill patients: a proof-of-concept post hoc analysis from the pBDG2 multicenter study.","authors":"Emmanuel Novy, Arnaud Schaeffer, Maxime Nguyen, Frédéric Dalle, Julien Pottecher, Valérie Letscher-Bru, Guillaume Louis, Charlotte Stephan, Amandine Luc, Marie Machouart, Anne Debourgogne","doi":"10.1186/s13054-026-05882-5","DOIUrl":"https://doi.org/10.1186/s13054-026-05882-5","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromuscular electrical stimulation for early rehabilitation in critically ill patients: a systematic review of applied protocols.","authors":"Nils Daum, Nils Drewniok, Annika Bald, Laura Homann, Linus Warner, Flora T Scheffenbichler, Antonia Leder, Max Liebl, Anett Reißhauer, Tobias Wollersheim, Stefan J Schaller, Steffen Weber-Carstens, Julius J Grunow","doi":"10.1186/s13054-026-05873-6","DOIUrl":"https://doi.org/10.1186/s13054-026-05873-6","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular phenotypes in pediatric sepsis identified by machine learning: prognostic implications for organ dysfunction and mortality.","authors":"Juan Carlos Beltrán, Jaime Fernández-Sarmiento, Alvaro David Orjuela-Cañón, L Nelson Sanchez-Pinto, Juan Pablo Fernández-Sarta, Isabella La Rotta, Daniel Fernández-Sarta, Alejandro Coutin, Juan Esteban Godoy, Hans Vink, Sainath Raman, Niranjan Kissoon","doi":"10.1186/s13054-025-05785-x","DOIUrl":"10.1186/s13054-025-05785-x","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":"30 1","pages":"61"},"PeriodicalIF":9.3,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12874729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Utility in prognostication of continuous EEG monitoring in postanoxic coma: importance on timing in relation to the cardiac arrest.","authors":"Stefan E Knapen, Wouter H Hinsenveld, Marcus L F Janssen, Werner H Mess, Judith Drenthen, Martijn R Tannemaat","doi":"10.1186/s13054-026-05872-7","DOIUrl":"10.1186/s13054-026-05872-7","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":"30 1","pages":"53"},"PeriodicalIF":9.3,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12866203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of transcranial Doppler for cerebral vasospasm in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.","authors":"Yoshihisa Fujimoto, Kohei Yamada, Takuo Yoshida","doi":"10.1186/s13054-026-05849-6","DOIUrl":"https://doi.org/10.1186/s13054-026-05849-6","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of inspiratory effort using airway occlusion pressure (ΔPocc) during non-invasive ventilation: a post-Hoc exploratory analysis.","authors":"Gustavo A Plotnikow, Roque S Moracci, Emilio Steinberg, Emiliano Gogniat","doi":"10.1186/s13054-025-05829-2","DOIUrl":"10.1186/s13054-025-05829-2","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":"30 1","pages":"52"},"PeriodicalIF":9.3,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12866048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline serum matrix metalloproteinase-8 and 28-day mortality in sepsis at ICU admission.","authors":"Huanqin Liu, Yingkui Song, Yanan Lv, Feng Qu, Jikui Shi","doi":"10.1186/s13054-026-05877-2","DOIUrl":"10.1186/s13054-026-05877-2","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":"30 1","pages":"51"},"PeriodicalIF":9.3,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12861068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of prone positioning on pathophysiology and lung histopathology during VV-ECMO in severe ARDS: an experimental animal study.","authors":"Enric Barbeta, Blanca Llonch, Jordi Vallverdú, Kasra Kiarostami, Luigi Zattera, Roberto Cabrera, Flavia Galli, Laia Fernández-Barat, Ana Motos, Filippo Sartori, Lisa Persico, Federico Carpenteri, Lucia Alessandra Pasqua, Nona Rovira-Ribalta, Cristina Miralles, Guillermo Laguna, Albert Carramiñana, Eduard Argudo, Maria Martínez-Martínez, Elisabet Gallart, Juan Antonio Sánchez, Katalin Rubí, Elena Sandoval, Maite Mata, Federica Piedepalumbo, Davide Calabretta, Carlos Ferrando, Jordi Riera, Antoni Torres","doi":"10.1186/s13054-026-05863-8","DOIUrl":"10.1186/s13054-026-05863-8","url":null,"abstract":"<p><strong>Background: </strong>Prone positioning improves survival in patients with acute respiratory distress syndrome (ARDS) by reducing ventilator-induced lung injury and enhancing ventilation-perfusion matching. Whether these physiological benefits translate to patients supported with veno-venous extracorporeal membrane oxygenation (VV-ECMO) remains uncertain.</p><p><strong>Methods: </strong>This study compared the effects of prone versus supine positioning on the wet-to-dry lung weight ratio, gas exchange, respiratory mechanics, electrical impedance tomography, histopathology, microbiology, hemodynamics, and extracorporeal circuit function in pigs with severe ARDS undergoing VV-ECMO. Pigs with severe ARDS were placed on VV-ECMO according to EOLIA criteria and then randomized to either prone or supine positioning for 48 h, while receiving an ultraprotective ventilation strategy. Futility analyses were performed at half of the planned sample size using conditional power calculations, with early termination criteria set at < 10% probability of achieving statistical significance.</p><p><strong>Results: </strong>Eight pigs with severe ARDS were randomized after VV-ECMO initiation. Prone positioning, compared with the supine position, resulted in a similar wet-to-dry lung weight ratio (6.77 [6.13-8.17] vs. 6.70 [6.22-8.48]; p = 0.89), meeting the futility threshold. Compared with the supine position, prone positioning significantly reduced the proportion of ventilation in non-dependent lung regions (51 [47-61.25]% vs. 86 [68.50-90]%; p = 0.02), thereby indicating a redistribution of ventilation toward dependent areas. Consistent with this shift in ventilation distribution, prone positioning redistributed histopathological lung injury, with relative preservation of non-dependent regions and greater damage in dependent zones, but without a net global decrease. Shunt fraction approached 100% in both groups, with no significant differences. Pulmonary CO₂ elimination was 8.45 (1.45-26.13) mL/min in the prone group and 0 (0-0.70) mL/min in the supine group (p = 0.23). Lung compliance showed no intergroup differences (14.67 [12.75-19.91] vs. 16.68 [15.51-19.47] mL/cmH₂O; p = 0.88), with similarly elevated end-inspiratory transpulmonary pressures. No significant differences were observed in systemic or pulmonary hemodynamics, nor in VV-ECMO circuit function.</p><p><strong>Conclusions: </strong>Prone positioning did not decrease the overall severity of lung injury. Rather, it shifted the distribution of damage, with greater involvement of dependent regions and relative preservation of non-dependent areas.</p>","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":"62"},"PeriodicalIF":9.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12879356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical applications for the endotoxin activity assay in sepsis: a scoping review.","authors":"Yohei Komaru, Akinori Maeda, Ryota Inokuchi, Debra M Foster, John A Kellum, Kent Doi","doi":"10.1186/s13054-026-05868-3","DOIUrl":"https://doi.org/10.1186/s13054-026-05868-3","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of ultrasound-guided infraclavicular axillary vein cannulation for centrally inserted central catheter placement in critically ill patients: systematic review with meta-analysis and trial sequential analysis.","authors":"Tomasz Królicki, Mateusz Zawadka, Magdalena Lis, Anna Królicka, Ryszard Gawda, Tomasz Czarnik","doi":"10.1186/s13054-026-05869-2","DOIUrl":"https://doi.org/10.1186/s13054-026-05869-2","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}