Critical Care最新文献

{"title":"Critical illness at extreme age: outcomes and clinical characteristics of centenarian ICU admissions in Australia and New Zealand.","authors":"Nattaya Raykateeraroj, Laurence Weinberg, Sean Yip, Carl Reyneke, Jacob Zand, Bernice Wang, Jemin Suh, Anoop Koshy, David Pilcher, Dong-Kyu Lee","doi":"10.1186/s13054-026-05968-0","DOIUrl":"https://doi.org/10.1186/s13054-026-05968-0","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and long-term mortality in cardiogenic shock: a binational multicentre cohort study.","authors":"Ryan Ruiyang Ling, Shir Lynn Lim, David M Kaye, Oliver Lim, Christopher Jer Wei Low, Graeme MacLaren, Daniel I McIsaac, Kiran Shekar, Ryo Ueno, David Pilcher, Kollengode Ramanathan, Ashwin Subramaniam","doi":"10.1186/s13054-026-05962-6","DOIUrl":"https://doi.org/10.1186/s13054-026-05962-6","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary angiopoietin-2 is associated with adverse kidney outcomes in the ICU.","authors":"Zoie A Bailey, Jordan J Lo, Christine P Limonte, Elizabeth Kiernan, Ayesha Khader, Julia Hallowell, Sarah L Speckmaier, Mark M Wurfel, Eric D Morrell, Ian B Stanaway, Leila R Zelnick, W Conrad Liles, Pavan K Bhatraju","doi":"10.1186/s13054-026-05960-8","DOIUrl":"https://doi.org/10.1186/s13054-026-05960-8","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":"30 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating DPP3 limits efficacy of angiotensin II infusion in septic shock.","authors":"Dirk van Lier, Karine Santos, Oliver Hartmann, Matthijs Kox, Peter Pickkers","doi":"10.1186/s13054-026-05971-5","DOIUrl":"https://doi.org/10.1186/s13054-026-05971-5","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":"30 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventricular arrhythmia ablation timing and outcomes in electrical STORM requiring V-A ECMO support: the STORM-ECMO study.","authors":"Ouriel Saura, Manuela Lucenteforte, Maxime Beneyto, Philippe Maury, Caroline Biendel, Frederic Sacher, Romain Tixier, Julien Imbault, Pierre Bay, Nicolas Lellouche, Francis Bessière, Kevin Gardey, Matteo Pozzi, Adrien Bouglé, Geoffroy Hariri, Eloi Marijon, Pierre Baudinaud, Anne-Celine Martin, Nicolas Brechot, Raphaël Martins, Pierre Groussin, Romain Sonneville, David Levy, Guillaume Lebreton, Pascal Leprince, Estelle Gandjbakhch, Alain Combes, Xavier Waintraub, Matthieu Schmidt","doi":"10.1186/s13054-026-05969-z","DOIUrl":"https://doi.org/10.1186/s13054-026-05969-z","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the interpretation of meta-analytic findings in cangrelor research.","authors":"Alice Bottussi, Jacopo D'Andria Ursoleo, Fabrizio Monaco, Patrick M Wieruszewski","doi":"10.1186/s13054-026-05963-5","DOIUrl":"https://doi.org/10.1186/s13054-026-05963-5","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":"30 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of proenkephalin A 119-159 for prediction of worsening renal function and prognosis in patients with sepsis -results of a patient-level meta-analysis.","authors":"Birte Arlt, Pietro Caironi, Jennifer Meessen, Oliver Hartmann, Alexandre Mebazaa, Matthieu Legrand, Etienne Gayat, Christian Nusshag, Thorsten Brenner, Pierre François Laterre, Ornella Tinelli, Roberto Latini, Florian Uhle","doi":"10.1186/s13054-026-05947-5","DOIUrl":"https://doi.org/10.1186/s13054-026-05947-5","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albumin 20% in surgical and critically ill patients; a comprehensive review.","authors":"Robert G Hahn, François Jardot, Randal O Dull, Joachim Zdolsek, Patrick Y Wuethrich","doi":"10.1186/s13054-026-05959-1","DOIUrl":"https://doi.org/10.1186/s13054-026-05959-1","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the pilot analogy.","authors":"Beatriz Lobo-Valbuena, Sara Alcántara Carmona","doi":"10.1186/s13054-026-05970-6","DOIUrl":"10.1186/s13054-026-05970-6","url":null,"abstract":"","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":"30 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early seizures and heterogeneity of physiologic recovery in heat-related illness: a nationwide registry study.","authors":"Koichi Inukai, Koki Terakawa, Takuya Matsui, Takayuki Hattori, Miyuu Uchida, Shiho Tane, Yu Hashimoto, Masanori Kawamoto, Fumitaka Kato, Koji Amano, Hiroyuki Kayata, Hideaki Yakushiji, Nobutaka Mukai, Naoki Shinyama, Akihiro Usui, Masanori Morita","doi":"10.1186/s13054-026-05961-7","DOIUrl":"https://doi.org/10.1186/s13054-026-05961-7","url":null,"abstract":"<p><strong>Background: </strong>Generalized seizures in heatstroke have traditionally been interpreted as a clinical sign of severe central nervous system involvement. However, it remains uncertain whether seizures documented early in the disease course uniformly reflect irreversible injury or may be observed in patients with preserved short-interval physiologic responsiveness. We aimed to characterize early physiologic trajectories associated with early seizures and to explore their association with in-hospital mortality.</p><p><strong>Methods: </strong>We conducted a retrospective nationwide cohort study of adults hospitalized with heat-related illness in the Japanese Association for Acute Medicine Heatstroke and Hypothermia Surveillance (JAAM-HsS) registry from 2017 to 2024. Early seizures were defined as generalized seizures observed or documented during prehospital transport or the initial emergency department assessment. The primary objective was to compare Day 1-Day 2 short-interval trajectories of key metabolic, electrolyte, and fluid-balance markers by early seizure status using linear mixed-effects models, focusing on seizure-by-time interactions. In-hospital mortality was evaluated as a secondary observational outcome using prespecified multivariable logistic regression (with vs. without lactate) and 1:1 propensity score matching, with attention to negative confounding and survivorship-related bias.</p><p><strong>Results: </strong>Of 3,859 patients, 408 (10.6%) had early seizures. Patients with early seizures exhibited greater initial derangement (higher body temperature and lactate and lower base excess) yet showed more rapid short-interval normalization of base excess, lactate, glucose, and serum sodium by Day 2 (all interaction p < 0.05). In-hospital mortality was 180/3,451 (5.2%) without early seizures and 27/408 (6.6%) with early seizures. In multivariable models adjusting for measured covariates, early seizures were inversely associated with mortality (lactate-included: aOR 0.48, 95% CI 0.27-0.86; lactate-excluded: aOR 0.57, 95% CI 0.33-0.99). This inverse association was directionally consistent after propensity score matching.</p><p><strong>Conclusions: </strong>Early seizures in heat-related illness were associated with a distinct short-interval trajectory phenotype that may help calibrate early prognostication. An inverse association with in-hospital mortality was observed in adjusted and covariate-balanced analyses; however, this should be interpreted as a secondary marker-outcome association and may reflect residual or negative confounding, including differential seizure ascertainment among the most moribund patients. These findings are hypothesis-generating and warrant prospective validation with higher-granularity neurologic and treatment data.</p>","PeriodicalId":10811,"journal":{"name":"Critical Care","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}