膳食中补充紫檀芪可激活 PI3K-AKT-mTOR 信号通路,从而缓解进行性氧化应激并促进胎盘营养运输。

IF 6.3 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of Animal Science and Biotechnology Pub Date : 2024-10-06 DOI:10.1186/s40104-024-01090-9
Mingming Cao, Liyun Bai, Haoyun Wei, Yantong Guo, Guodong Sun, Haoyang Sun, Baoming Shi
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引用次数: 0

摘要

背景:由于胎儿的快速发育和泌乳强度的增加,母体新陈代谢的强度逐渐增加,很容易发生渐进性氧化应激。然而,有关过程性氧化应激对胎盘中营养物质运输的影响的研究却很少受到关注。本研究以妊娠 85 天的母猪为对象,研究紫檀芪(PTE)对母体氧化应激状态和胎盘营养运输的影响:结果:PTE 提高了母体血液和乳汁中的抗氧化能力和免疫球蛋白含量,降低了炎症因子水平,改善了乳汁的营养成分。PTE 还能减少母猪背膘损失和弱仔数,增加仔猪断奶重和断奶窝总重。我们随后发现,PTE 可增强胎盘葡萄糖和脂肪酸的转运,并通过增加 LAL、PYGM 和 Gbe-1 的表达进一步影响糖脂代谢,从而激活 PI3K 磷酸化途径。此外,PTE 的添加还改变了母猪粪便中固着菌、变形菌、副杆菌和类杆菌 RF16 群的相对丰度。PTE 增加了粪便中乙酸酯、丙酸酯、丁酸酯和异戊酸酯的含量:这些研究结果表明,在妊娠期和哺乳期添加 PTE 可通过改变母体微生物和胎盘的营养运输能力,减轻过程性氧化应激对后代发育的影响。
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Dietary supplementation with pterostilbene activates the PI3K-AKT-mTOR signalling pathway to alleviate progressive oxidative stress and promote placental nutrient transport.

Background: Progressive oxidative stress easily occurs as a result of a gradual increase in the intensity of maternal metabolism due to rapid foetal development and increased intensity of lactation. However, studies on the effects of processive oxidative stress on nutrient transport in the placenta have received little attention. The present study was conducted on sows at 85 days of gestation to study the effects of pterostilbene (PTE) on maternal oxidative stress status and placental nutrient transport.

Results: PTE increased the antioxidant capacity and immunoglobulin content in mothers' blood and milk, reduced the level of inflammatory factors, and improved the nutrient content of milk. PTE also reduced sow backfat loss and the number of weak sons, and increased piglet weaning weight and total weaning litter weight. We subsequently found that PTE enhanced placental glucose and fatty acid transport and further affected glycolipid metabolism by increasing the expression of LAL, PYGM, and Gbe-1, which activated the PI3K phosphorylation pathway. Moreover, PTE addition altered the relative abundance of the Firmicutes, Proteobacteria, Parabacillus, and Bacteroidetes-like RF16 groups in sow faeces. PTE increased the levels of acetate, propionate, butyrate and isovalerate in the faeces.

Conclusions: These findings reveal that the addition of PTE during pregnancy and lactation mitigates the effects of processive oxidative stress on offspring development by altering maternal microbial and placental nutrient transport capacity.

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