肿瘤微环境中的新陈代谢和巨噬细胞

IF 6.6 2区 医学 Q1 IMMUNOLOGY Current Opinion in Immunology Pub Date : 2024-10-04 DOI:10.1016/j.coi.2024.102491
Hannah Yang , Chan Kim , Weiping Zou
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引用次数: 0

摘要

肿瘤相关巨噬细胞(TAMs)是肿瘤微环境(TME)中免疫细胞的主要亚群。TAMs 具有表型和功能异质性,在癌症患者的肿瘤发生、发展和治疗反应中发挥着不同的作用。为了对 TME 中的各种免疫和代谢线索做出反应,TAMs 会动态地改变其代谢特征以适应环境。TAMs体内葡萄糖、氨基酸和脂质代谢的变化,以及它们与本体代谢产物的相互作用,不仅维持了它们的能量需求,还影响了它们对肿瘤免疫反应的影响。了解 TAMs 代谢重编程及其协调代谢过程的分子机制,可为开发针对 TAMs 的新型癌症免疫疗法提供启示。在此,我们将讨论新陈代谢如何重编 TME 中的巨噬细胞,并回顾旨在使 TAMs 的新陈代谢改变正常化并减轻 TAM 介导的免疫抑制和原癌活动的临床试验。
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Metabolism and macrophages in the tumor microenvironment
Tumor-associated macrophages (TAMs) constitute the primary subset of immune cells within the tumor microenvironment (TME). Exhibiting both phenotypic and functional heterogeneity, TAMs play distinct roles in tumor initiation, progression, and responses to therapy in patients with cancer. In response to various immune and metabolic cues within the TME, TAMs dynamically alter their metabolic profiles to adapt. Changes in glucose, amino acid, and lipid metabolism in TAMs, as well as their interaction with oncometabolites, not only sustain their energy demands but also influence their impact on tumor immune responses. Understanding the molecular mechanisms underlying the metabolic reprogramming of TAMs and their orchestration of metabolic processes can offer insights for the development of novel cancer immunotherapies targeting TAMs. Here, we discuss how metabolism reprograms macrophages in the TME and review clinical trials aiming to normalize metabolic alterations in TAMs and alleviate TAM-mediated immune suppression and protumor activity.
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来源期刊
CiteScore
13.30
自引率
1.40%
发文量
94
审稿时长
67 days
期刊介绍: Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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