蛋白质组学证据表明,种子气味改变了散食性动物的嗅觉和空间记忆。

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Behavioural Brain Research Pub Date : 2024-10-05 DOI:10.1016/j.bbr.2024.115282
Xiangyu Zhao, Yingnan Wang, Xianfeng Yi
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引用次数: 0

摘要

种子气味在影响小型啮齿类动物的分散囤积行为方面起着至关重要的作用,它们依靠空间记忆和嗅觉来囤积和恢复。然而,关于种子气味如何改变嗅觉功能和空间记忆的证据仍然缺乏。在这里,我们用防水胶涂覆种子,测试了种子气味强度如何改变中国西南地区一种优势分散囤积啮齿动物(Leopoldamys edwardsi)的嗅球和海马的蛋白质组。我们的研究表明,反复贮藏和回收气味微弱种子的动物表现出更强的嗅觉能力和空间记忆能力,嗅球和海马的蛋白质谱发生了改变。与嗅球和海马神经连接密切相关的蛋白质的上调是嗅觉功能和空间记忆改善的重要原因。我们的研究从神经生物学的角度为散囤啮齿动物如何管理和应对气味强度不同的种子提供了新的见解,这对于更好地理解嗅觉系统和海马系统的平行进化具有重要意义。
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Proteomic evidence for seed odor modifying olfaction and spatial memory in a scatter-hoarding animal
Seed odor plays a crucial role in affecting the scatter-hoarding behavior of small rodents that rely on spatial memory and olfaction to cache and recover. However, evidence of how seed odor modifies olfaction function and spatial memory is still lacking. Here, we coated seeds with waterproof glue to test how seed odor intensity alters the proteome of both the olfactory bulbs and hippocampus of a dominant scatter-hoarding rodent, Leopoldamys edwardsi, in Southwest China. We showed that animals repeatedly caching and recovering weak odor seeds exhibited greater olfactory ability and spatial memory, as indicated by alterations in the protein profiles of the olfactory bulbs and hippocampus. The upregulation of proteins closely related to neural connections between the olfactory bulb and hippocampus is highly responsible for improved olfactory function and spatial memory. Our study provides new insights into how scatter-hoarding rodents manage and respond to cached seeds differing in odor intensity from a neurobiological perspective, which is of significant importance for better understanding the parallel evolution of the olfactory and hippocampal systems.
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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