XuWen Zheng, MaoBing Chen, Yi Zhuang, Liang Zhao, YongJun Qian, ChengCheng Shi
{"title":"揭示肠道微生物群与哮喘之间的遗传联系：孟德尔随机法。","authors":"XuWen Zheng, MaoBing Chen, Yi Zhuang, Liang Zhao, YongJun Qian, ChengCheng Shi","doi":"10.3389/fmicb.2024.1448629","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Multiple studies suggest a potential connection between the gut microbiome and asthma. Our objective is to use advanced genetic and metagenomic techniques to elucidate the causal relationships and underlying mechanisms between gut microbiota and asthma.</p><p><strong>Methods: </strong>The study utilized comprehensive Linkage Disequilibrium Score Regression (LDSC) and Mendelian randomization (MR) analyses to examine the relationship between 119 gut microbiota genera and asthma, using publicly accessible genome-wide association studies (GWAS). The meta-analysis synthesized summary effect estimates obtained from LDSC, forward MR, and reverse MR. The MiBioGen collaboration, involving 18,340 individuals, identified genetic variations associated with gut bacteria. Asthma data were collected from the UK Biobank, FinnGen, and GERA, encompassing a total of 82,060 cases and 641,049 controls.</p><p><strong>Results: </strong>LDSC analysis revealed significant negative genetic correlations between asthma and <i>RuminococcaceaeUCG004</i> (Rg = -0.55, <i>p</i> = 7.66 × 10<sup>-5</sup>) and <i>Subdoligranulum</i> (Rg = -0.35, <i>p</i> = 3.61 × 10<sup>-4</sup>). Forward MR analysis suggested associations between <i>Butyricicoccus</i> (OR = 0.92, <i>p</i> = 0.01), <i>Turicibacter</i> (OR = 0.95, <i>p</i> = 0.025), <i>Butyrivibrio</i> (OR = 0.98, <i>p</i> = 0.047), and reduced asthma risk. Conversely, <i>Coprococcus2</i> (OR = 1.10, <i>p</i> = 0.035) and <i>Roseburia</i> (OR = 1.07, <i>p</i> = 0.039) were associated with increased risk. Reverse MR analysis indicated significant associations between genetically predicted asthma and <i>Eubacteriumxylanophilumgroup</i> (Beta = -0.08, <i>p</i> = 9.25 × 10<sup>-7</sup>), <i>LachnospiraceaeNK4A136group</i> (Beta = -0.05, <i>p</i> = 1.26 × 10<sup>-4</sup>), and <i>Eisenbergiella</i> (Beta = 0.06, <i>p</i> = 0.015, Rg_<i>P</i> = 0.043).</p><p><strong>Conclusion: </strong>The findings underscore significant genetic correlations and causal relationships between specific gut microbiota and asthma. These insights highlight the potential of gut microbiota as both markers and modulators of asthma risk, offering new avenues for targeted therapeutic strategies.</p>","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449699/pdf/","citationCount":"0","resultStr":"{\"title\":\"Unveiling genetic links between gut microbiota and asthma: a Mendelian randomization.\",\"authors\":\"XuWen Zheng, MaoBing Chen, Yi Zhuang, Liang Zhao, YongJun Qian, ChengCheng Shi\",\"doi\":\"10.3389/fmicb.2024.1448629\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Multiple studies suggest a potential connection between the gut microbiome and asthma. Our objective is to use advanced genetic and metagenomic techniques to elucidate the causal relationships and underlying mechanisms between gut microbiota and asthma.</p><p><strong>Methods: </strong>The study utilized comprehensive Linkage Disequilibrium Score Regression (LDSC) and Mendelian randomization (MR) analyses to examine the relationship between 119 gut microbiota genera and asthma, using publicly accessible genome-wide association studies (GWAS). The meta-analysis synthesized summary effect estimates obtained from LDSC, forward MR, and reverse MR. The MiBioGen collaboration, involving 18,340 individuals, identified genetic variations associated with gut bacteria. Asthma data were collected from the UK Biobank, FinnGen, and GERA, encompassing a total of 82,060 cases and 641,049 controls.</p><p><strong>Results: </strong>LDSC analysis revealed significant negative genetic correlations between asthma and <i>RuminococcaceaeUCG004</i> (Rg = -0.55, <i>p</i> = 7.66 × 10<sup>-5</sup>) and <i>Subdoligranulum</i> (Rg = -0.35, <i>p</i> = 3.61 × 10<sup>-4</sup>). Forward MR analysis suggested associations between <i>Butyricicoccus</i> (OR = 0.92, <i>p</i> = 0.01), <i>Turicibacter</i> (OR = 0.95, <i>p</i> = 0.025), <i>Butyrivibrio</i> (OR = 0.98, <i>p</i> = 0.047), and reduced asthma risk. Conversely, <i>Coprococcus2</i> (OR = 1.10, <i>p</i> = 0.035) and <i>Roseburia</i> (OR = 1.07, <i>p</i> = 0.039) were associated with increased risk. Reverse MR analysis indicated significant associations between genetically predicted asthma and <i>Eubacteriumxylanophilumgroup</i> (Beta = -0.08, <i>p</i> = 9.25 × 10<sup>-7</sup>), <i>LachnospiraceaeNK4A136group</i> (Beta = -0.05, <i>p</i> = 1.26 × 10<sup>-4</sup>), and <i>Eisenbergiella</i> (Beta = 0.06, <i>p</i> = 0.015, Rg_<i>P</i> = 0.043).</p><p><strong>Conclusion: </strong>The findings underscore significant genetic correlations and causal relationships between specific gut microbiota and asthma. These insights highlight the potential of gut microbiota as both markers and modulators of asthma risk, offering new avenues for targeted therapeutic strategies.</p>\",\"PeriodicalId\":12466,\"journal\":{\"name\":\"Frontiers in Microbiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2024-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449699/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3389/fmicb.2024.1448629\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3389/fmicb.2024.1448629","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Unveiling genetic links between gut microbiota and asthma: a Mendelian randomization.
Background: Multiple studies suggest a potential connection between the gut microbiome and asthma. Our objective is to use advanced genetic and metagenomic techniques to elucidate the causal relationships and underlying mechanisms between gut microbiota and asthma.
Methods: The study utilized comprehensive Linkage Disequilibrium Score Regression (LDSC) and Mendelian randomization (MR) analyses to examine the relationship between 119 gut microbiota genera and asthma, using publicly accessible genome-wide association studies (GWAS). The meta-analysis synthesized summary effect estimates obtained from LDSC, forward MR, and reverse MR. The MiBioGen collaboration, involving 18,340 individuals, identified genetic variations associated with gut bacteria. Asthma data were collected from the UK Biobank, FinnGen, and GERA, encompassing a total of 82,060 cases and 641,049 controls.
Results: LDSC analysis revealed significant negative genetic correlations between asthma and RuminococcaceaeUCG004 (Rg = -0.55, p = 7.66 × 10-5) and Subdoligranulum (Rg = -0.35, p = 3.61 × 10-4). Forward MR analysis suggested associations between Butyricicoccus (OR = 0.92, p = 0.01), Turicibacter (OR = 0.95, p = 0.025), Butyrivibrio (OR = 0.98, p = 0.047), and reduced asthma risk. Conversely, Coprococcus2 (OR = 1.10, p = 0.035) and Roseburia (OR = 1.07, p = 0.039) were associated with increased risk. Reverse MR analysis indicated significant associations between genetically predicted asthma and Eubacteriumxylanophilumgroup (Beta = -0.08, p = 9.25 × 10-7), LachnospiraceaeNK4A136group (Beta = -0.05, p = 1.26 × 10-4), and Eisenbergiella (Beta = 0.06, p = 0.015, Rg_P = 0.043).
Conclusion: The findings underscore significant genetic correlations and causal relationships between specific gut microbiota and asthma. These insights highlight the potential of gut microbiota as both markers and modulators of asthma risk, offering new avenues for targeted therapeutic strategies.
期刊介绍：
Frontiers in Microbiology is a leading journal in its field, publishing rigorously peer-reviewed research across the entire spectrum of microbiology. Field Chief Editor Martin G. Klotz at Washington State University is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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