用不同的化学计量学方法测定人尿样中的阿尔茨海默氏症药物:阿尔茨海默氏症药物的化学计量测定。

IF 1.5 4区 化学 Q3 CHEMISTRY, ANALYTICAL International Journal of Analytical Chemistry Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI:10.1155/2024/5535816
Güzide Pekcan
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引用次数: 0

摘要

本研究采用统计学方法对健康人尿样中的多奈哌齐和利伐斯的明进行了分光光度测定。采用多元定标法中的偏最小二乘法(PLS)和主成分回归法(PCR)来评估尿样紫外可见光谱分析所获得的数据。在尿样分析前制备了每种早期物质的混合物,并根据已建立的化学计量学模型同时测定多奈哌齐和利伐斯的明,而无需事先进行任何分离。分析了每种药物的校准曲线,并对线性值进行了分析。多奈哌齐和利伐斯的明的线性值分别为 0.9989 和 0.9997,在合成混合物的浓度范围内呈线性关系。在对两种化学计量法(PLS 和 PCR)的准确性和重现性进行评估时,确定了极高的回收率和较小的标准偏差。在 PLS 方法中,多奈哌齐和利维斯的明的预测标准误差(SEC)、预测残差误差之和(PRESS)、定量限(LOQ)和检测限(LOD)值分别为 0.015、0.0030、0.067、0.24、0.018、0.0042、0.089 和 0.301。在 PCR 方法中,多奈哌齐的 SEC 值、PRESS 值、LOD 值和 LOQ 值分别为 0.016、0.0054、0.066 和 0.23;利伐斯的明的 SEC 值、PRESS 值、LOD 值和 LOQ 值分别为 0.022、0.0062、0.091 和 0.300。采用化学计量学方法具有快速、简单和可靠的特点。所提出的方法已成功应用于尿液样本。
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Determination of Alzheimer's Drugs in a Human Urine Sample by Different Chemometric Methods: Chemometric Determination of Alzheimer's Drugs.

In this study, spectrophotometric determination of donepezil and rivastigmine in healthy human urine samples was carried out by the statistical method. Partial least squares (PLS) and principal component regression (PCR) from multivariate calibration methods were used to evaluate the data obtained from the UV-Vis spectroscopy analysis of the urine sample. Mixtures of each early substance were prepared prior to urine sample analysis, and simultaneous determination of donepezil and rivastigmine was performed on the established chemometric model without any prior separation. The calibration curves of each drug were analyzed, and linearity values were also analyzed. For donepezil and rivastigmine, they were 0.9989 and 0.9997, respectively, and were linear over the concentration range of the synthetic mixture. When both chemometric methods (PLS and PCR) were evaluated in terms of accuracy and reproducibility, very high recoveries and small standard deviations were determined. In the PLS method, the standard error of prediction (SEC), the sum of the prediction residual errors (PRESS), the limit of quantitation (LOQ), and the limit of detection (LOD) values were 0.015, 0.0030, 0.067, 0.24, 0.018, 0.0042, 0.089, and 0.301 for donepezil and rivastigmine, respectively. In the PCR method, SEC, PRESS, LOD, and LOQ values are 0.016, 0.0054, 0.066, and 0.23 for donepezil and 0.022, 0.0062, 0.091, and 0.300 for rivastigmine. Chemometrics is used for speed, simplicity, and reliability. The proposed methods have been successfully applied to a sample of urine.

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来源期刊
CiteScore
3.10
自引率
5.60%
发文量
117
期刊介绍: International Journal of Analytical Chemistry publishes original research articles that report new experimental results and methods, especially in relation to important analytes, difficult matrices, and topical samples. Investigations may be fundamental, or else related to specific applications; examples being biological, environmental and food testing, and analysis in chemical synthesis and materials processing. As well as original research, the International Journal of Analytical Chemistry also publishes focused review articles that examine the state of the art, identify emerging trends, and suggest future directions for developing fields.
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