超越边界：神经炎症期间脉络丛与免疫的交流

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Signal Transduction and Targeted Therapy Pub Date : 2024-10-08 DOI:10.1038/s41392-024-01997-9

Anaelle Aurelie Dumas, Adrià Dalmau Gasull, Marco Prinz

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引用次数: 0

摘要

在发表于《细胞》1 的论文中，Xu 等人利用单细胞测序和细胞系追踪工具，结合双光子实时成像技术，描述了脉络丛（ChP）的时空免疫招募和浸润特征。他们对专门的脉络丛上皮细胞和巨噬细胞群之间的交流提供了开创性的见解，这些细胞群协调了对炎症的逐步反应和解决。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Beyond borders: the choroid plexus-immune communication during neuroinflammation

In their paper published in Cell,¹ Xu et al. leveraged single-cell sequencing and cell lineage tracing tools combined with two-photon live imaging to characterise the spatiotemporal immune recruitment and infiltration to the choroid plexus (ChP). They provide seminal insights into the communication between specialised ChP epithelial and macrophage populations, which coordinate the stepwise response to inflammation and its resolution.

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.