是时候建立一个新的框架,将儿童肥胖症作为一种基于脂肪的慢性疾病来治疗了

IF 58.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nature Medicine Pub Date : 2024-10-08 DOI:10.1038/s41591-024-03292-0
Melania Manco, Tryggvi Helgason, Antje Körner, Paulina Nowicka, Grace O’Malley, Jennifer L. Baker
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引用次数: 0

摘要

欧洲肥胖症研究协会(European Association for the Study of Obesity)1 的作者最近出版了《成人肥胖症诊断、分期和管理新框架》一书,为成人肥胖症的诊断和治疗提供了一个实用的框架。该文件为更有针对性地评估和治疗成人肥胖症铺平了道路。虽然作者在这篇论文中特意将重点放在成人肥胖症上,但他们提出的框架与在儿科人群中观察到的情况非常吻合,并为一些考虑因素提供了基础。正如该文章1 中所述,体重指数并不能反映成人脂肪堆积和功能障碍的严重程度。在儿童中,即使根据年龄和性别进行正常化处理,体重指数也不能反映出脂肪堆积和功能障碍的严重程度2,3。在儿科环境中,以腹围、腰围-身高比和其他指数来衡量内脏脂肪的年龄和性别特异性参考值的概念,是以反映身体持续增长的需要为坚实基础的。这些指数中很少有反映儿童内脏脂肪的参考值。这是一个严重的疏忽,因为毫无疑问,肥胖是一种以脂肪为基础的儿童慢性疾病4。准确量化过多的脂肪及其对儿童或青少年健康和功能的影响至关重要。
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Time for a new framework that treats obesity in children as an adiposity-based chronic disease

The recent publication ‘A new framework for the diagnosis, staging and management of obesity in adults’ by authors from the European Association for the Study of Obesity1 illustrates a practical context for the diagnosis and treatment of obesity in adults. The document paves the way for more tailored assessment and treatment of obesity in adults. Although the authors deliberately focused on obesity in adults in this work, the framework they propose fits well with what is observed in the pediatric population and provides a basis for some considerations.

As described in that article1, body mass index does not reflect the severity of fat accumulation and dysfunction in adults. In children, it does so even less even if it is normalized for age and sex2,3. In the pediatric setting, the concept of age- and sex-specific references for visceral fat measured as abdominal circumference, waist-to-height ratio and other indices is firmly grounded in the need to reflect continuous body growth. Few of these indices are well referenced to reflect visceral fat in children. This is a critical oversight, as without a doubt, obesity is an adiposity-based chronic disease in children4. Accurate quantification of excess adiposity and how it affects the health and function of the child or adolescent is crucial.

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来源期刊
Nature Medicine
Nature Medicine 医学-生化与分子生物学
CiteScore
100.90
自引率
0.70%
发文量
525
审稿时长
1 months
期刊介绍: Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.
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