用于大规模醇类有氧氧化的新型 CuI/oxalamide 催化系统

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC European Journal of Organic Chemistry Pub Date : 2024-10-08 DOI:10.1002/ejoc.202400804

Kexue Xing, Jicong Xiang, Zijin Luo, Guiyuan Liu, Xianghao Zhang, Guofu Zhang, Chengrong Ding

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引用次数: 0

摘要

自从草酰胺配体被报道以来，它们已被广泛用于高效构建各种类型的 C-X（如 C、N、O 和 S）键。为了评估草酰胺配体易于调整的电子特性和独特的配位模式是否也能在氧化领域大放异彩，我们启动了草酰胺配体/铜/空气氧化研究，并将其应用于醇的氧化，以评估其实用性和潜在应用。通过 100 毫摩尔规模的放大反应和克级规模的药物分子衍生化反应，进一步验证了这一策略的实用性。

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A new CuI/oxalamide catalytic system for the large-scale aerobic oxidation of alcohols

Since the report of oxamide ligands, they have been widely used for the efficient construction of various types of C-X (such as C, N, O and S) bonds. To evaluate whether the easily tunable electronic properties and unique coordination modes of oxamide ligands can also shine in the field of oxidation, we initiated a study on oxamide ligand/copper/air oxidation and applied it to the oxidation of alcohols to assess its practicality and potential applications. The practicality of this strategy was further verified through scale-up reactions on a 100 mmol scale and gram-scale derivatization of pharmaceutical molecules.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.