尼可地尔水凝胶通过靶向 Hmox1 促进骨缺损重建

IF 5.4 2区医学 Q1 BIOPHYSICS Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-05 DOI:10.1016/j.colsurfb.2024.114299

Renkai Wang , Zhilong Pi , Xiang Zhu , Xinzhe Wang , Hao Zhang , Fang Ji , Hao Tang

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引用次数: 0

摘要

背景：在局部使用药物促进骨愈合仍难以应用于临床。我们旨在构建一种尼可地尔水凝胶，通过促进血管生成和抑制破骨细胞生成来促进局部骨愈合：本研究构建了一种尼可地尔水凝胶，并将其用于骨缺损重建过程中的骨修复干预。结果表明，尼可地尔水凝胶在体外明显抑制破骨细胞分化，促进血管生成。此外，使用尼可地尔水凝胶还能明显促进骨形成。从机理上讲，尼可地尔直接靶向 Hmox1，发现过表达 Hmox1 可促进骨缺损重建：我们的研究为使用局部尼可地尔水凝胶改善骨缺损重建提供了新的视角和潜在的治疗方法。

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Nicorandil-based hydrogel promotes bone defect reconstruction by targeting Hmox1

Background

The local use of drugs to promote bone healing is still difficult to apply clinically. We aimed to construct a nicorandil-based hydrogel to promote local bone healing by promoting angiogenesis and inhibiting osteoclastogenesis.

Results

In this study, we constructed a nicorandil-based hydrogel and used it to intervene in bone repair during bone defect reconstruction. The results showed that the nicorandil-based hydrogel significantly inhibited osteoclast differentiation and promoted angiogenesis in vitro. Furthermore, bone formation was significantly promoted by the use of a nicorandil-based hydrogel. Mechanistically, Hmox1 was directly targeted by nicorandil, and overexpression of Hmox1 was found to promote bone defect reconstruction.

Conclusion

Our study provides a fresh perspective and a potential therapeutic approach for the use of local nicorandil-based hydrogels to improve bone defect reconstruction.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.