脑瘫的神经生物学启示:机制与治疗策略综述》。

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Brain and Behavior Pub Date : 2024-10-08 DOI:10.1002/brb3.70065
Izere Salomon
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引用次数: 0

摘要

背景:脑性瘫痪(CP)是一种常见的神经发育障碍疾病,其特征是由于脑损伤或发育异常而导致的行动和姿势障碍。CP 与多种神经机制和途径有关,这些机制和途径会影响运动障碍的类型和严重程度以及合并症。临床表型、发病机制和病因的异质性给有效的治疗干预带来了巨大挑战:综述旨在全面分析 CP 的神经生物学机制,评估当前和未来的治疗策略,强调有必要采取有针对性的干预措施来解决该疾病的多面性:方法:我们进行了全面的文献综述,重点关注发表在同行评审期刊上的研究,这些研究探讨了 CP 的病理生理机制、临床干预措施和治疗策略:结果:CP 的发病机制涉及遗传、环境和围产期因素的复杂相互作用,导致脑损伤。炎症过程、氧化应激和兴奋毒性在 CP 的发展过程中至关重要。目前的治疗方法主要侧重于通过物理和职业疗法以及药物干预来控制症状。包括抗炎剂、抗氧化剂、神经保护剂和神经营养剂在内的新兴疗法显示出潜力,但还需要进一步验证。值得注意的是,尽管类固醇具有抗炎作用,但在儿童患者中使用类固醇会引发骨质疏松症等长期不良反应:尽管对 CP 神经生物学基础的认识取得了进展,但有效的治疗目标仍然难以捉摸。针对 CP 的异质性采取综合方法至关重要。未来的研究应强调对治疗药物的疗效和安全性进行深入评估,尤其是在儿科人群中,以开发针对 CP 的有效治疗方法。
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Neurobiological Insights Into Cerebral Palsy: A Review of the Mechanisms and Therapeutic Strategies

Background

Cerebral palsy (CP) is a common neurodevelopmental disorder characterized by impaired mobility and posture caused by brain injury or abnormal development. CP relates to a variety of neurological mechanisms and pathways that impact the type and severity of motor disability, as well as comorbidities. The heterogeneity in clinical phenotype, pathogenesis, and etiology poses significant challenges for effective therapeutic intervention.

Objectives

The review aims to provide a comprehensive analysis of the neurobiological mechanisms underlying CP and evaluate current and prospective therapeutic strategies, highlighting the necessity for targeted interventions to address the disorder's multifaceted nature.

Methods

A thorough literature review was conducted, focusing on studies published in peer-reviewed journals that explore the pathophysiological mechanisms, clinical interventions, and therapeutic strategies for CP.

Results

The pathogenesis of CP involves a complex interplay of genetic, environmental, and perinatal factors leading to brain injury. Inflammatory processes, oxidative stress, and excitotoxicity are critical in CP development. Current therapeutic approaches primarily focus on symptom management through physical and occupational therapy, as well as pharmacological interventions. Emerging therapies, including anti-inflammatory agents, antioxidants, and neuroprotective and neurotrophic agents, show potential but require further validation. Notably, although steroids provide anti-inflammatory benefits, their use in pediatric patients raises concerns regarding long-term adverse effects such as osteoporosis.

Conclusion

Despite advances in understanding CP's neurobiological underpinnings, effective therapeutic targets remain elusive. A comprehensive approach addressing CP's heterogeneity is essential. Future research should emphasize in-depth evaluations of the efficacy and safety of therapeutic agents, particularly in pediatric populations, to develop targeted and effective treatments for CP.

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来源期刊
Brain and Behavior
Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES
CiteScore
5.30
自引率
0.00%
发文量
352
审稿时长
14 weeks
期刊介绍: Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)
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