Pierre Courault, Sandrine Bouvard, Caroline Bouillot, Radu Bolbos, Waël Zeinyeh, Thibaut Iecker, François Liger, Thierry Billard, Luc Zimmer, Fabien Chauveau, Sophie Lancelot
{"title":"肥胖成像的前景:[18F]2FNQ1P--一种特异性 5-HT6 脑 PET 放射性示踪剂。","authors":"Pierre Courault, Sandrine Bouvard, Caroline Bouillot, Radu Bolbos, Waël Zeinyeh, Thibaut Iecker, François Liger, Thierry Billard, Luc Zimmer, Fabien Chauveau, Sophie Lancelot","doi":"10.1038/s41366-024-01644-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Estimates suggest that approximatively 25% of the world population will be overweight in 2025. Better understanding of the pathophysiology of obesity will help to develop future therapeutics. Serotonin subtype 6 receptors (5-HT<sub>6</sub>) have been shown to be critically involved in appetite reduction and weight loss. However, it is not known if the pathological cascade triggered by obesity modifies the density of 5-HT<sub>6</sub> receptors in the brain.</p><p><strong>Methods: </strong>Influence of diet-induced obesity (DIO) in Wistar rats was explored using MRI (whole-body fat) and PET ([<sup>18</sup>F]2FNQ1P as a specific 5-HT<sub>6</sub> radiotracer). The primary goal was to monitor the 5-HT<sub>6</sub> receptor density before and after a 10-week diet (DIO group). The secondary goal was to compare 5-HT<sub>6</sub> receptor densities between DIO group, Wistar control diet group, Zucker rats (with genetic obesity) and Zucker lean strain rats.</p><p><strong>Results: </strong>Wistar rats fed with high-fat diet showed higher body fat gain than Wistar control diet rats on MRI. [<sup>18</sup>F]2FNQ1P PET analysis highlighted significant clusters of voxels (located in hippocampus, striatum, cingulate, temporal cortex and brainstem) with increased binding after high-fat diet (p < 0.05, FWE corrected).</p><p><strong>Conclusion: </strong>This study sheds a new light on the influence of high-fat diet on 5-HT<sub>6</sub> receptors. This study also positions [<sup>18</sup>F]2FNQ1P PET as an innovative tool to explore neuronal consequences of obesity or eating disorder pathophysiology.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Perspectives on obesity imaging: [<sup>18</sup>F]2FNQ1P a specific 5-HT<sub>6</sub> brain PET radiotracer.\",\"authors\":\"Pierre Courault, Sandrine Bouvard, Caroline Bouillot, Radu Bolbos, Waël Zeinyeh, Thibaut Iecker, François Liger, Thierry Billard, Luc Zimmer, Fabien Chauveau, Sophie Lancelot\",\"doi\":\"10.1038/s41366-024-01644-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Estimates suggest that approximatively 25% of the world population will be overweight in 2025. Better understanding of the pathophysiology of obesity will help to develop future therapeutics. Serotonin subtype 6 receptors (5-HT<sub>6</sub>) have been shown to be critically involved in appetite reduction and weight loss. However, it is not known if the pathological cascade triggered by obesity modifies the density of 5-HT<sub>6</sub> receptors in the brain.</p><p><strong>Methods: </strong>Influence of diet-induced obesity (DIO) in Wistar rats was explored using MRI (whole-body fat) and PET ([<sup>18</sup>F]2FNQ1P as a specific 5-HT<sub>6</sub> radiotracer). The primary goal was to monitor the 5-HT<sub>6</sub> receptor density before and after a 10-week diet (DIO group). The secondary goal was to compare 5-HT<sub>6</sub> receptor densities between DIO group, Wistar control diet group, Zucker rats (with genetic obesity) and Zucker lean strain rats.</p><p><strong>Results: </strong>Wistar rats fed with high-fat diet showed higher body fat gain than Wistar control diet rats on MRI. [<sup>18</sup>F]2FNQ1P PET analysis highlighted significant clusters of voxels (located in hippocampus, striatum, cingulate, temporal cortex and brainstem) with increased binding after high-fat diet (p < 0.05, FWE corrected).</p><p><strong>Conclusion: </strong>This study sheds a new light on the influence of high-fat diet on 5-HT<sub>6</sub> receptors. This study also positions [<sup>18</sup>F]2FNQ1P PET as an innovative tool to explore neuronal consequences of obesity or eating disorder pathophysiology.</p>\",\"PeriodicalId\":14183,\"journal\":{\"name\":\"International Journal of Obesity\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41366-024-01644-x\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Obesity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41366-024-01644-x","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Perspectives on obesity imaging: [18F]2FNQ1P a specific 5-HT6 brain PET radiotracer.
Background: Estimates suggest that approximatively 25% of the world population will be overweight in 2025. Better understanding of the pathophysiology of obesity will help to develop future therapeutics. Serotonin subtype 6 receptors (5-HT6) have been shown to be critically involved in appetite reduction and weight loss. However, it is not known if the pathological cascade triggered by obesity modifies the density of 5-HT6 receptors in the brain.
Methods: Influence of diet-induced obesity (DIO) in Wistar rats was explored using MRI (whole-body fat) and PET ([18F]2FNQ1P as a specific 5-HT6 radiotracer). The primary goal was to monitor the 5-HT6 receptor density before and after a 10-week diet (DIO group). The secondary goal was to compare 5-HT6 receptor densities between DIO group, Wistar control diet group, Zucker rats (with genetic obesity) and Zucker lean strain rats.
Results: Wistar rats fed with high-fat diet showed higher body fat gain than Wistar control diet rats on MRI. [18F]2FNQ1P PET analysis highlighted significant clusters of voxels (located in hippocampus, striatum, cingulate, temporal cortex and brainstem) with increased binding after high-fat diet (p < 0.05, FWE corrected).
Conclusion: This study sheds a new light on the influence of high-fat diet on 5-HT6 receptors. This study also positions [18F]2FNQ1P PET as an innovative tool to explore neuronal consequences of obesity or eating disorder pathophysiology.
期刊介绍:
The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders.
We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.