组蛋白去乙酰化酶和 NADPH 氧化酶对心血管疾病的调节。

IF 10.7 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Biology Pub Date : 2024-10-04 DOI:10.1016/j.redox.2024.103379

Hui Yan , Yidan Yin , Yichen Zhou , Zhanghang Li , Yuxing Li , Lingxuan Ren , Jiazheng Wen , Weirong Wang

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引用次数: 0

摘要

组蛋白去乙酰化酶（HDACs）在心血管疾病（CVDs）中起着至关重要的作用。此外，NADPH 氧化酶（NOXs）产生的活性氧（ROS）会因氧化应激对心脏和血管产生破坏作用。虽然依赖于 NOX 的 ROS 生成与发病机制有关，但 HDAC 与 NOX 在心血管疾病中的关系仍有待阐明。在此，我们概述了 HDAC 和 NOX 在心血管疾病中的调控作用和相互关联的信号通路。提高对这些关系的认识将有助于发现针对 HDACs、氧化酶应激途径以及这些系统之间相互作用的新型治疗药物，这些药物可能对心血管疾病的预防和治疗非常有效。

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Regulation of cardiovascular diseases by histone deacetylases and NADPH oxidases

Histone deacetylases (HDACs) play critical roles in cardiovascular diseases (CVDs). In addition, reactive oxygen species (ROS) produced by NADPH oxidases (NOXs) exert damaging effects due to oxidative stress on heart and blood vessels. Although NOX-dependent ROS production is implicated in pathogenesis, the relationship between HDACs and NOXs in CVDs remains to be elucidated. Here, we present an overview of the regulatory effects and interconnected signaling pathways of HDACs and NOXs in CVDs. Improved insights into these relationships will facilitate the discovery of novel therapeutic agents that target HDACs, oxidase stress pathways, and the interactions between these systems which may be highly effective in the prevention and treatment of cardiovascular disorders.

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来源期刊

Redox Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

19.90

自引率

3.50%

发文量

318

审稿时长

25 days

期刊介绍： Redox Biology is the official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe. It is also affiliated with the International Society for Free Radical Research (SFRRI). This journal serves as a platform for publishing pioneering research, innovative methods, and comprehensive review articles in the field of redox biology, encompassing both health and disease. Redox Biology welcomes various forms of contributions, including research articles (short or full communications), methods, mini-reviews, and commentaries. Through its diverse range of published content, Redox Biology aims to foster advancements and insights in the understanding of redox biology and its implications.