肺组织中的石棉暴露诊断。

IF 4.4 Q1 PATHOLOGY PATHOLOGICA Pub Date : 2024-08-01 DOI:10.32074/1591-951X-930
Donata Bellis, Alessandro Croce, Alex Glorioso, Marinella Bertolotti, Antonio Maconi
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引用次数: 0

摘要

诊断石棉沉滞症需要不同的标准,这取决于是在临床环境还是在医疗/法律环境中。就后者而言,只有当出现 "与石棉体(ABs)相关的弥漫性间质纤维化 "时,才能说是石棉沉滞症。考虑到医疗/法律环境,诊断必须是确定的和经过证实的。遗憾的是,通常很难通过光学显微镜(LM)来识别 ABs,但这并不意味着临床上应排除这一诊断。其他参数也很重要,如工作史和/或影像诊断。除了通常用于诊断的光学显微镜外,还有其他技术,例如:扫描电子显微镜和附带的显微分析微探针(SEM/EDS),但它们需要对组织进行消化,成本较高。利用微拉曼光谱和扫描电镜/电子显微镜技术的新方法能够分析组织切片,而无需其他可能干扰石棉纤维分析的操作。在这项工作中,我们提出了一种用于石棉沉滞症诊断的算法,特别是在法医领域,证明了多个专业人员之间密切合作的重要性。
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Asbestos exposure diagnosis in pulmonary tissues.

The diagnosis of asbestosis requires different criteria depending on whether it is in a clinical or medical/legal setting. In the latter context, only when a "diffuse interstitial fibrosis associated to asbestos bodies (ABs)" is present, it can be said to be asbestosis. Considering the medical/legal setting, the diagnosis must be certain and proven. Unfortunately, it is often difficult to identify ABs by light microscopy (LM), but this does not mean that the diagnosis should be clinically excluded. Other parameters are important, such as working history and/or diagnostic imaging. In addition to LM, normally used for diagnosis, there are other techniques, e.g.: scanning electron microscopy with attached microanalysis microprobe (SEM/EDS), but they require tissue digestion and higher cost. A new approach with micro-Raman spectroscopy and SEM/EDS techniques is able to analyse histological sections without other manipulations that could interfere with analysis of asbestos fibres. In this work, we propose an algorithm for asbestosis diagnosis, especially in the forensic medical field, demonstrating the importance of close collaboration between multiple professionals.

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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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