高强度间歇训练会改变肥胖和糖尿病老年大鼠的肌肉再生信号蛋白,但螺旋藻补充剂不会。

IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL European Journal of Translational Myology Pub Date : 2024-10-09 DOI:10.4081/ejtm.2024.12761
Roya Askari, Marzieh Sadat Azarniveh, Amir Hossein Haghighi, Hadi Shahrabadi, Paulo Gentil
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引用次数: 0

摘要

本研究旨在探讨肥胖和糖尿病老年大鼠在接受高强度间歇训练(HIIT)和补充 SP 后,与肌肉再生相关的蛋白质信号的变化。本研究使用了 40 只体重 280-325 克的雄性 Wistar 大鼠。肥胖是通过八周的高脂饮食诱发的,糖尿病是通过腹腔注射 40 毫克/千克链脲佐菌素诱发的。大鼠被随机分为对照组(CON)、假组、SP组、HIIT组和HIIT+SP组。在为期 8 周的时间里,每周进行五次 HIIT。SP 剂量为 50 毫克/千克。采用实时 PCR 评估肌原蛋白、MyoD1 和 Pax7 的表达。HIIT组、HIIT+SP组和SP组的体重下降幅度明显高于假组和CON组(P=0.0001)。比目鱼肌质量仅在 HIIT 组和 HIIT+SP 组有明显增加(P=0.0001)。
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High-intensity interval training, but not Spirulina supplementation, changes muscle regeneration signaling proteins in aged rats with obesity and diabetes.

This study aimed to investigate changes in protein signaling associated with muscle regeneration in aged rats with obesity and diabetes following high-intensity interval training (HIIT) and SP supplementation. Forty male Wistar rats weighting 280-325 g were used in this study. Obesity was induced by eight weeks of a high-fat diet, and diabetes was induced by intraperitoneal injection of 40 mg/kg streptozocin. Rats were randomly divided into control (CON), sham, SP, HIIT, and HIIT+SP groups. HIIT was performed five times per week during the 8-week period. SP dose was 50 mg/kg. Real-time PCR was used to evaluate the expression of myogenin, MyoD1, and Pax7. The decreases in body mass in the HIIT, HIIT+SP and SP groups were significantly higher than those in the sham and CON groups (p=0.0001). The soleus muscle mass increased significantly only in the HIIT and HIIT+SP groups (p<0.01). HIIT+SP improved fasting blood glucose and insulin levels more than HIIT alone and SP (p<0.05), while HIIT increased the expression levels of myogenic factors more than other groups (p=0.0001). In conclusion HIIT alone had a significant impact on myogenic factors, whereas Spirulina had an effect only when combined with HIIT.

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来源期刊
European Journal of Translational Myology
European Journal of Translational Myology MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.30
自引率
27.30%
发文量
74
审稿时长
10 weeks
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