European Journal of Translational Myology最新文献

Medium-sized scientific conferences held in hotels large enough to accommodate all participants increase opportunities for constructive discussion during breaks, and for evenings that bring together young and senior experts of basic sciences and clinical specialties. Time for group discussions offer opportunities for new collaborations and for jobs for young researchers. Since 1991 the Padova Muscle Days have offered collaborative opportunities that have matured into innovative multidisciplinary results to the point that it came naturally for us to underline it with a neologism now included in the title of the 2025 event: "Mobility Medicine". It is a discipline which developed naturally when we brought together fragmented areas of knowledge into one meeting. The Padua Days on Muscle and Mobility Medicine 2025 (2025Pdm3) will be hosted at the Hotel Petrarca, Euganean Thermae (Padua, Italy) from 25 to 29 March 2025. The list of unique sessions within the included program and the following Collection of Abstracts testify that it is possible to organize valid countermeasures to the inevitable tendencies towards hyper-specialization that the explosive increase in scientific progress brings. The European Journal of Translational Myology and Mobility Medicine (Ejtm3) will accept typescripts on results presented at the 2025Pdm3. Furthermore, an additional option for publication of full original Articles or Reviews is the Special "New Trends in Musculoskeletal Imaging" of the MDPI Journal Diagnostics, because diagnosis is essential to manage and follow-up neuro- metabolic- muscular- disorder and the decay of performances in aging. We hope that many will share our dreams and we make them come true at the 2025 Pdm3 Conference.

In dentistry, surface electromyography (sEMG) is currently used in both clinical and research fields to study the electrical activity of the masticatory muscles, such as the anterior Temporals and Masseters, which are easily accessible. Due to biological and technical factors that can alter the capture of the sEMG signal, comparing recordings obtained from the same subject at different days, with electrode replacement, can be challenging, thus complicating inter- and intra-subject sEMG comparisons. In the present study, sEMG activity of the masticatory muscles during maximum teeth clenching was simultaneously recorded using two different electrode configurations (A and B) to simulate different electrodes positioning as may occur between appointments. Raw sEMG signals and standardised indexes based on acquisitions from configurations A and B were compared. The position of the electrodes significantly affected the sEMG raw potentials of the masticatory muscles during maximum teeth clenching, while standardised indexes were not influenced by electrode positioning.

This study aimed to evaluate the role of NLR in predicting outcomes for patients with moderate to severe TBI. A retrospective analysis was conducted from April 2020 to April 2022, including patients aged 16 and older with Glasgow Coma Scale (GCS) scores of 8 or below admitted to Shahid Beheshti Hospital, Kashan. Data on NLR and other clinical markers were collected. Rotterdam scores were calculated using CT scan findings. Patients were followed up for six months post-trauma or until death, and associations between NLR and clinical outcomes were analyzed, with significance set at P < 0.05. Among 195 patients, 130 (66%) had unfavorable outcomes at six months. Admission NLR was significantly higher in patients with unfavorable outcomes compared to those with favorable outcomes (P < 0.001). Receiver operating characteristic analysis indicated that NLR had a sensitivity of 82% and specificity of 91% at a threshold of 5.2 for predicting unfavorable outcomes. Elevated admission NLR in patients with severe TBI was linked to unfavorable six-month functional outcomes and mortality. NLR may serve as a readily accessible clinical marker for prognostication in moderate to severe TBI.

This retrospective study, utilising prospectively collected data, investigates the use of spine ultrasound as an alternative method for assessing scoliosis, with the aim of reducing radiation exposure. We included 92 patients aged 10 to 16 years with suspected idiopathic scoliosis. Exclusion criteria were weight over 150 kg, metal implants, pre-existing conditions, secondary deformities, and cognitive impairments. Each patient underwent clinical assessment and full spine radiographs, followed by spine ultrasound using the Scolioscan® system. Unprocessed B-mode ultrasound images were analysed using automatic measurements. The correlation between Ultrasound Coronal Angle (UCA) and Radiographic Cobb Angle (RCA) was evaluated at initial and follow-up visits. Strong correlations were found between UCA and RCA, with correlation coefficients ranging from 0.786 to 0.903 (p < 0.001). The regression formula showed good predictive accuracy for curve progression on follow-up radiographs. The best results were observed in females and in primary thoracic curves (r = 0.936, p < 0.001). Although only four patients exhibited true progression (≥5° increase in Cobb angle), changes in scoliotic angles were effectively detected using ultrasound. This study confirms the feasibility of unprocessed spine ultrasound for scoliosis monitoring in clinical settings. Automatic measurements without 3D reconstruction make ultrasound a practical tool for tracking progression. The regression model shows potential for predicting curve progression, although further validation is needed. These findings suggest spine ultrasound could reduce the need for radiographs, benefiting patients by minimising radiation exposure while providing reliable monitoring of scoliosis progression and treatment outcomes.

The intricate relationship between gut microbiota and the brain has emerged as a pivotal area of research, particularly in understanding myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This complex condition is characterized by debilitating fatigue, cognitive dysfunction, and a wide array of systemic manifestations, posing significant challenges for diagnosis and treatment. Recent studies highlight the microbiota-gut-brain axis as a crucial pathway in ME/CFS pathophysiology, suggesting that alterations in gut microbial composition may impact immune responses, neurochemical signaling, and neuronal health. This narrative review systematically explores English-language scholarly articles from January 1995 to January 2025, utilizing databases such as PubMed, Scopus, and Web of Science. The findings underscore the potential for targeted therapeutic interventions aimed at correcting gut dysbiosis. As research progresses, a deeper understanding of the microbiota-gut-brain connection could lead to innovative approaches for managing ME/CFS, ultimately enhancing the quality of life for affected individuals.

The term "local electrical stimulation" means the delivery, for therapeutic purposes, of electric current signals in the areola of the projections of acupuncture points. Among the varieties of this effect are electro- and electroacupuncture, as well as transcutaneous electrical neurostimulation. In the case of electropuncture, minimal skin areas are irritated, outside of the damage, by placing the sensors according to the projections of the points. In the electroacupuncture, current signals are sent to steel needles immersed in tissues, ensuring the activation of not only skin afferents, but also deeper afferents. Percutaneous stimulation consists of irritating large areas of the skin with the help of portable devices. The paper reveals the mechanisms underlying the therapeutic effect of these methods, and puts forward an assumption about the prevailing biological significance of low-intensity stimuli. In addition, specific examples of use of local electrical stimulation in a number of pathological conditions are also presented.

We invariably hear that Artificial Intelligence (AI), a rapidly evolving technology, does not just creatively assemble known knowledge. We are told that AI learns, processes and creates, starting from fixed points to arrive at innovative solutions. In the case of scientific work, AI can generate data without ever having entered a laboratory, (i.e., blatantly plagiarizing the existing literature, a despicable old trick). How does an editor of a scientific journal recognize when she or he is faced with something like this? The solution is for editors and referees to rigorously evaluate the track records of submitting authors and what they are doing. For example, false color evaluations of 2D and 3D CT and MRI images have been used to validate functional electrical stimulation for degenerated denervated muscle and a home Full-Body In-Bed Gym program. These have been recently published in Ejtm and other journals. The editors and referees of Ejtm can exclude the possibility that the images were invented by ChatGPT. Why? Because they know the researchers: Marco Quadrelli, Aldo Morra, Daniele Coraci, Paolo Gargiulo and their collaborators as well! Artificial intelligence is not banned by the EJTM, but when submitting their manuscripts to previous and to a new Thematic Section dedicated to Generative AI in Translational Mobility Medicine authors must openly declare whether they have used artificial intelligence, of what type and for what purposes. This will not avoid risks of plagiarism or worse, but it will better establish possible liabilities.

Background: Transplant recipients are given an immunosuppressive regimen such as tacrolimus to prevent organ rejection. Suprotac® is a generic tacrolimus that is utilized in kidney transplantation regimen in Iran. This post-market study was conducted to evaluate the safety and efficacy of Suprotac® in comparison with Prograf®.

Methods: In this two-armed, open-label, parallel, active-controlled, and cohort study, de novo kidney transplant recipients aging 18 to 65 years were prescribed Suprotac® or Prograf® as part of the immunosuppressant protocol. The primary outcome was comparing the mean estimated glomerular filtration rate (eGFR) at month 12. The secondary outcomes were the assessment of patient and graft survival, acute rejections during hospitalization, tacrolimus dose, trough concentration, and trough concentration/dose (C/D) ratio, and adverse events (AEs) during the study period.

Results: A total of 201 patients were enrolled in this study. At discharge, the eGFR was lower in the Suprotac® group compared to the Prograf® group (51.70 ml/min/1.73m2 and 57.48 ml/min/1.73m2, respectively; p = 0.042). However, at month 12, there was no significant difference in mean eGFR between the two groups (58.94 ml/min/1.73m2 and 59.78 ml/min/1.73m2, respectively; p = 0.772). Other outcomes, including patient and graft survival, acute rejection during hospitalization, tacrolimus dose, trough concentration, and C/D ratio, and overall incidence of AEs were similar between the two groups (p > 0.05).

Conclusion: The efficacy and safety profile of the generic tacrolimus were shown to be comparable to the reference tacrolimus at month 12.

The aim of the study is to compare improvement outcomes in patients (aged between 8 and 18 years old) with idiopathic scoliosis treated with a traditional technique with those treated with an innovative method. The study included 17 participants allocated into two groups: experimental (n = 8) and control (n = 9) groups. The first group was treated with a new method with PosturalSpine® D'Amanti method, twice a week for 30 min per session while the second group was treated with kinesitherapy and traditional tools three times week for 45 min per session. The two groups are similar in the anthropometric characteristics, in baseline Risser index and in the Cobb angles average and no statistically significant differences were found between the two groups. After one year of motor intervention, both treatment groups showed improvements in the progression of scoliotic curves and the PosturalSpine® group showed a significantly higher improvement than the control group. Our results therefore suggest that this new specific method with PosturalSpine® D'Amanti method could play a significant role in improving adolescent idiopathic scoliosis compared to traditional exercises.

Hyperbaric oxygen therapy (HBOT) is a non-invasive method of O2 delivery that induces systemic hyperoxia. Hyperbaric chamber consists of a pressure vessel and a compressed breathing gas supply, which can regulate internal pressure. The chamber delivers 100% O2 to patients according to predetermined protocols and is monitored by trained personnel. HBOT relies on increasing the inspired O2 fraction (fiO2) and elevating the partial pressure of O2 (pO2). O2 is typically administered at pressures between 1.5 and 3.0 ATA for 60 to 120 minutes, depending on the clinical presentation. Currently, there are 15 indications for HBOT approved by the Undersea and Hyperbaric Medicine Society, categorized into three groups: emergency medicine, wound healing acceleration, and antimicrobial effects. The present narrative review aims to elucidate the mechanisms action underlying HBOT, particularly oxy-inflammation, in various pathologies within these categories.