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Standardised indexes reduce the variability of masticatory muscles electromyographic values.
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-02-25 DOI: 10.4081/ejtm.2025.13420
Riccardo Rosati, Daniela Carmagnola, Gaia Pellegrini, Dolaji Henin, Massimiliano Vella, Claudia Dellavia

In dentistry, surface electromyography (sEMG) is currently used in both clinical and research fields to study the electrical activity of the masticatory muscles, such as the anterior Temporals and Masseters, which are easily accessible. Due to biological and technical factors that can alter the capture of the sEMG signal, comparing recordings obtained from the same subject at different days, with electrode replacement, can be challenging, thus complicating inter- and intra-subject sEMG comparisons. In the present study, sEMG activity of the masticatory muscles during maximum teeth clenching was simultaneously recorded using two different electrode configurations (A and B) to simulate different electrodes positioning as may occur between appointments. Raw sEMG signals and standardised indexes based on acquisitions from configurations A and B were compared. The position of the electrodes significantly affected the sEMG raw potentials of the masticatory muscles during maximum teeth clenching, while standardised indexes were not influenced by electrode positioning.

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引用次数: 0
A comparative analysis of Rotterdam score and neutrophil-to-lymphocyte ratio in predicting outcomes for patients with moderate to severe traumatic brain injury.
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-02-21 DOI: 10.4081/ejtm.2025.13443
Hamidreza Aghadoost, Ghazaleh Salehabadi, Esmaeil Fakharian, Hanieh Jafari Mohammadabad

This study aimed to evaluate the role of NLR in predicting outcomes for patients with moderate to severe TBI. A retrospective analysis was conducted from April 2020 to April 2022, including patients aged 16 and older with Glasgow Coma Scale (GCS) scores of 8 or below admitted to Shahid Beheshti Hospital, Kashan. Data on NLR and other clinical markers were collected. Rotterdam scores were calculated using CT scan findings. Patients were followed up for six months post-trauma or until death, and associations between NLR and clinical outcomes were analyzed, with significance set at P < 0.05. Among 195 patients, 130 (66%) had unfavorable outcomes at six months. Admission NLR was significantly higher in patients with unfavorable outcomes compared to those with favorable outcomes (P < 0.001). Receiver operating characteristic analysis indicated that NLR had a sensitivity of 82% and specificity of 91% at a threshold of 5.2 for predicting unfavorable outcomes. Elevated admission NLR in patients with severe TBI was linked to unfavorable six-month functional outcomes and mortality. NLR may serve as a readily accessible clinical marker for prognostication in moderate to severe TBI.

{"title":"A comparative analysis of Rotterdam score and neutrophil-to-lymphocyte ratio in predicting outcomes for patients with moderate to severe traumatic brain injury.","authors":"Hamidreza Aghadoost, Ghazaleh Salehabadi, Esmaeil Fakharian, Hanieh Jafari Mohammadabad","doi":"10.4081/ejtm.2025.13443","DOIUrl":"https://doi.org/10.4081/ejtm.2025.13443","url":null,"abstract":"<p><p>This study aimed to evaluate the role of NLR in predicting outcomes for patients with moderate to severe TBI. A retrospective analysis was conducted from April 2020 to April 2022, including patients aged 16 and older with Glasgow Coma Scale (GCS) scores of 8 or below admitted to Shahid Beheshti Hospital, Kashan. Data on NLR and other clinical markers were collected. Rotterdam scores were calculated using CT scan findings. Patients were followed up for six months post-trauma or until death, and associations between NLR and clinical outcomes were analyzed, with significance set at P < 0.05. Among 195 patients, 130 (66%) had unfavorable outcomes at six months. Admission NLR was significantly higher in patients with unfavorable outcomes compared to those with favorable outcomes (P < 0.001). Receiver operating characteristic analysis indicated that NLR had a sensitivity of 82% and specificity of 91% at a threshold of 5.2 for predicting unfavorable outcomes. Elevated admission NLR in patients with severe TBI was linked to unfavorable six-month functional outcomes and mortality. NLR may serve as a readily accessible clinical marker for prognostication in moderate to severe TBI.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound vs. x-ray: a new way for clinicians to track scoliosis progression?
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-02-21 DOI: 10.4081/ejtm.2025.13422
Samra Pjanić, Goran Talić, Nikola Jevtić, Filip Golić, Ivan Soldatović, Nachiappan Chockalingam

This retrospective study, utilising prospectively collected data, investigates the use of spine ultrasound as an alternative method for assessing scoliosis, with the aim of reducing radiation exposure. We included 92 patients aged 10 to 16 years with suspected idiopathic scoliosis. Exclusion criteria were weight over 150 kg, metal implants, pre-existing conditions, secondary deformities, and cognitive impairments. Each patient underwent clinical assessment and full spine radiographs, followed by spine ultrasound using the Scolioscan® system. Unprocessed B-mode ultrasound images were analysed using automatic measurements. The correlation between Ultrasound Coronal Angle (UCA) and Radiographic Cobb Angle (RCA) was evaluated at initial and follow-up visits. Strong correlations were found between UCA and RCA, with correlation coefficients ranging from 0.786 to 0.903 (p < 0.001). The regression formula showed good predictive accuracy for curve progression on follow-up radiographs. The best results were observed in females and in primary thoracic curves (r = 0.936, p < 0.001). Although only four patients exhibited true progression (≥5° increase in Cobb angle), changes in scoliotic angles were effectively detected using ultrasound. This study confirms the feasibility of unprocessed spine ultrasound for scoliosis monitoring in clinical settings. Automatic measurements without 3D reconstruction make ultrasound a practical tool for tracking progression. The regression model shows potential for predicting curve progression, although further validation is needed. These findings suggest spine ultrasound could reduce the need for radiographs, benefiting patients by minimising radiation exposure while providing reliable monitoring of scoliosis progression and treatment outcomes.

{"title":"Ultrasound <i>vs.</i> x-ray: a new way for clinicians to track scoliosis progression?","authors":"Samra Pjanić, Goran Talić, Nikola Jevtić, Filip Golić, Ivan Soldatović, Nachiappan Chockalingam","doi":"10.4081/ejtm.2025.13422","DOIUrl":"https://doi.org/10.4081/ejtm.2025.13422","url":null,"abstract":"<p><p>This retrospective study, utilising prospectively collected data, investigates the use of spine ultrasound as an alternative method for assessing scoliosis, with the aim of reducing radiation exposure. We included 92 patients aged 10 to 16 years with suspected idiopathic scoliosis. Exclusion criteria were weight over 150 kg, metal implants, pre-existing conditions, secondary deformities, and cognitive impairments. Each patient underwent clinical assessment and full spine radiographs, followed by spine ultrasound using the Scolioscan® system. Unprocessed B-mode ultrasound images were analysed using automatic measurements. The correlation between Ultrasound Coronal Angle (UCA) and Radiographic Cobb Angle (RCA) was evaluated at initial and follow-up visits. Strong correlations were found between UCA and RCA, with correlation coefficients ranging from 0.786 to 0.903 (p < 0.001). The regression formula showed good predictive accuracy for curve progression on follow-up radiographs. The best results were observed in females and in primary thoracic curves (r = 0.936, p < 0.001). Although only four patients exhibited true progression (≥5° increase in Cobb angle), changes in scoliotic angles were effectively detected using ultrasound. This study confirms the feasibility of unprocessed spine ultrasound for scoliosis monitoring in clinical settings. Automatic measurements without 3D reconstruction make ultrasound a practical tool for tracking progression. The regression model shows potential for predicting curve progression, although further validation is needed. These findings suggest spine ultrasound could reduce the need for radiographs, benefiting patients by minimising radiation exposure while providing reliable monitoring of scoliosis progression and treatment outcomes.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Microbiota-Gut-Brain Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Narrative Review of an Emerging Field.
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-02-12 DOI: 10.4081/ejtm.2025.13690
Amr Ali Mohamed Abdelgawwad El-Sehrawy, Ibtihal Ibrahim Ayoub, Subasini Uthirapathy, Suhas Ballal, Baneen C Gabble, Abhayveer Singh, Kavitha V, Rajashree Panigrahi, Mostafa Kamali, Mohsen Khosravi

The intricate relationship between gut microbiota and the brain has emerged as a pivotal area of research, particularly in understanding myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This complex condition is characterized by debilitating fatigue, cognitive dysfunction, and a wide array of systemic manifestations, posing significant challenges for diagnosis and treatment. Recent studies highlight the microbiota-gut-brain axis as a crucial pathway in ME/CFS pathophysiology, suggesting that alterations in gut microbial composition may impact immune responses, neurochemical signaling, and neuronal health. This narrative review systematically explores English-language scholarly articles from January 1995 to January 2025, utilizing databases such as PubMed, Scopus, and Web of Science. The findings underscore the potential for targeted therapeutic interventions aimed at correcting gut dysbiosis. As research progresses, a deeper understanding of the microbiota-gut-brain connection could lead to innovative approaches for managing ME/CFS, ultimately enhancing the quality of life for affected individuals.

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引用次数: 0
Local electrical stimulation: introduction to the problem.
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-02-05 DOI: 10.4081/ejtm.2025.13305
Lev G Agasarov, Maxim Yu Yakovlev, Tatyana V Konchugova, Larisa A Marchenkova, Victor A Drobyshev, Tatyana V Apkhanova, Tatyana E Belousova, Tatyana V Marfina, Nadezhda V Gushchina, Valeria A Vasileva, Anastasia A Mukhina, Irina A Grishechkina, Tatyana K Chernyavskaya, Elena P Ivanova

The term "local electrical stimulation" means the delivery, for therapeutic purposes, of electric current signals in the areola of the projections of acupuncture points. Among the varieties of this effect are electro- and electroacupuncture, as well as transcutaneous electrical neurostimulation. In the case of electropuncture, minimal skin areas are irritated, outside of the damage, by placing the sensors according to the projections of the points. In the electroacupuncture, current signals are sent to steel needles immersed in tissues, ensuring the activation of not only skin afferents, but also deeper afferents. Percutaneous stimulation consists of irritating large areas of the skin with the help of portable devices. The paper reveals the mechanisms underlying the therapeutic effect of these methods, and puts forward an assumption about the prevailing biological significance of low-intensity stimuli. In addition, specific examples of use of local electrical stimulation in a number of pathological conditions are also presented.

{"title":"Local electrical stimulation: introduction to the problem.","authors":"Lev G Agasarov, Maxim Yu Yakovlev, Tatyana V Konchugova, Larisa A Marchenkova, Victor A Drobyshev, Tatyana V Apkhanova, Tatyana E Belousova, Tatyana V Marfina, Nadezhda V Gushchina, Valeria A Vasileva, Anastasia A Mukhina, Irina A Grishechkina, Tatyana K Chernyavskaya, Elena P Ivanova","doi":"10.4081/ejtm.2025.13305","DOIUrl":"https://doi.org/10.4081/ejtm.2025.13305","url":null,"abstract":"<p><p>The term \"local electrical stimulation\" means the delivery, for therapeutic purposes, of electric current signals in the areola of the projections of acupuncture points. Among the varieties of this effect are electro- and electroacupuncture, as well as transcutaneous electrical neurostimulation. In the case of electropuncture, minimal skin areas are irritated, outside of the damage, by placing the sensors according to the projections of the points. In the electroacupuncture, current signals are sent to steel needles immersed in tissues, ensuring the activation of not only skin afferents, but also deeper afferents. Percutaneous stimulation consists of irritating large areas of the skin with the help of portable devices. The paper reveals the mechanisms underlying the therapeutic effect of these methods, and puts forward an assumption about the prevailing biological significance of low-intensity stimuli. In addition, specific examples of use of local electrical stimulation in a number of pathological conditions are also presented.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ejtm3 experiences after ChatGPT and other AI approaches: values, risks, countermeasures.
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-01-30 DOI: 10.4081/ejtm.2025.13670
Giorgio Fanò-Illic, Daniele Coraci, Maria Chiara Maccarone, Stefano Masiero, Marco Quadrelli, Aldo Morra, Barbara Ravara, Amber Pond, Riccardo Forni, Paolo Gargiulo

We invariably hear that Artificial Intelligence (AI), a rapidly evolving technology, does not just creatively assemble known knowledge. We are told that AI learns, processes and creates, starting from fixed points to arrive at innovative solutions. In the case of scientific work, AI can generate data without ever having entered a laboratory, (i.e., blatantly plagiarizing the existing literature, a despicable old trick). How does an editor of a scientific journal recognize when she or he is faced with something like this? The solution is for editors and referees to rigorously evaluate the track records of submitting authors and what they are doing. For example, false color evaluations of 2D and 3D CT and MRI images have been used to validate functional electrical stimulation for degenerated denervated muscle and a home Full-Body In-Bed Gym program. These have been recently published in Ejtm and other journals. The editors and referees of Ejtm can exclude the possibility that the images were invented by ChatGPT. Why? Because they know the researchers: Marco Quadrelli, Aldo Morra, Daniele Coraci, Paolo Gargiulo and their collaborators as well! Artificial intelligence is not banned by the EJTM, but when submitting their manuscripts to previous and to a new Thematic Section dedicated to Generative AI in Translational Mobility Medicine authors must openly declare whether they have used artificial intelligence, of what type and for what purposes. This will not avoid risks of plagiarism or worse, but it will better establish possible liabilities.

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引用次数: 0
Evaluation of efficacy and safety of generic tacrolimus (Suprotac®) compared to reference tacrolimus (Prograf®) in kidney transplantation: a phase IV study. 非专利他克莫司(Suprotac®)与参比他克莫司(Prograf®)在肾移植中的疗效和安全性评价:一项IV期研究。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-01-21 DOI: 10.4081/ejtm.2025.13203
Behzad Einollahi, Mohsen Nafar, Mohammad Javanbakht, Amirhesam Alirezaei, Jalal Azmandian, Abbas Etminan, Mohammad Reza Ardalan, Jalal Etemadi, Roghayeh Akbari, Vahid Pourfarziani, Seyed Sadraddin Rasi Hashemi, Seyed Maryam Rahbar, Shahrzad Shahidi, Javid Safa, Hamid Tayyebi Khosroshahi, Sima Abedi Azar, Shahrzad Ossareh, Abdolamir Atapour, Bahareh Marghoob, Fatemeh Nazemian, Hamidreza Kafi, Araz Sabzvari

Background: Transplant recipients are given an immunosuppressive regimen such as tacrolimus to prevent organ rejection. Suprotac® is a generic tacrolimus that is utilized in kidney transplantation regimen in Iran. This post-market study was conducted to evaluate the safety and efficacy of Suprotac® in comparison with Prograf®.

Methods: In this two-armed, open-label, parallel, active-controlled, and cohort study, de novo kidney transplant recipients aging 18 to 65 years were prescribed Suprotac® or Prograf® as part of the immunosuppressant protocol. The primary outcome was comparing the mean estimated glomerular filtration rate (eGFR) at month 12. The secondary outcomes were the assessment of patient and graft survival, acute rejections during hospitalization, tacrolimus dose, trough concentration, and trough concentration/dose (C/D) ratio, and adverse events (AEs) during the study period.

Results: A total of 201 patients were enrolled in this study. At discharge, the eGFR was lower in the Suprotac® group compared to the Prograf® group (51.70 ml/min/1.73m2 and 57.48 ml/min/1.73m2, respectively; p = 0.042). However, at month 12, there was no significant difference in mean eGFR between the two groups (58.94 ml/min/1.73m2 and 59.78 ml/min/1.73m2, respectively; p = 0.772). Other outcomes, including patient and graft survival, acute rejection during hospitalization, tacrolimus dose, trough concentration, and C/D ratio, and overall incidence of AEs were similar between the two groups (p > 0.05).

Conclusion: The efficacy and safety profile of the generic tacrolimus were shown to be comparable to the reference tacrolimus at month 12.

背景:移植受者给予免疫抑制方案,如他克莫司,以防止器官排斥。Suprotac®是一种通用的他克莫司,在伊朗用于肾移植方案。本上市后研究旨在评估Suprotac®与Prograf®的安全性和有效性。方法:在这项双臂、开放标签、平行、主动对照和队列研究中,年龄在18至65岁之间的新肾移植受者被处方Suprotac®或Prograf®作为免疫抑制剂方案的一部分。主要结果是比较12个月时的平均肾小球滤过率(eGFR)。次要结果是评估患者和移植物的生存、住院期间的急性排斥反应、他克莫司剂量、谷浓度、谷浓度/剂量(C/D)比和研究期间的不良事件(ae)。结果:本研究共纳入201例患者。出院时,Suprotac®组eGFR低于Prograf®组(分别为51.70 ml/min/1.73m2和57.48 ml/min/1.73m2);P = 0.042)。然而,在第12个月,两组之间的平均eGFR无显著差异(分别为58.94 ml/min/1.73m2和59.78 ml/min/1.73m2;P = 0.772)。其他结果,包括患者和移植物存活、住院期间急性排斥反应、他克莫司剂量、谷浓度、C/D比和总ae发生率在两组之间相似(p < 0.05)。结论:仿制药他克莫司在12个月时的疗效和安全性与参比药他克莫司相当。
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引用次数: 0
New horizons for adolescent idiopathic scoliosis treatment through PosturalSpine® D'Amanti Method. PosturalSpine®D'Amanti方法治疗青少年特发性脊柱侧凸的新视野。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-01-21 DOI: 10.4081/ejtm.2025.13313
Francesca Campoli, Maria Chiara Parisi, Antonino Zoffoli, Donatella Di Corrado, Vincenzo Francavilla, Elvira Padua, Giuseppe Messina

The aim of the study is to compare improvement outcomes in patients (aged between 8 and 18 years old) with idiopathic scoliosis treated with a traditional technique with those treated with an innovative method. The study included 17 participants allocated into two groups: experimental (n = 8) and control (n = 9) groups. The first group was treated with a new method with PosturalSpine® D'Amanti method, twice a week for 30 min per session while the second group was treated with kinesitherapy and traditional tools three times week for 45 min per session. The two groups are similar in the anthropometric characteristics, in baseline Risser index and in the Cobb angles average and no statistically significant differences were found between the two groups. After one year of motor intervention, both treatment groups showed improvements in the progression of scoliotic curves and the PosturalSpine® group showed a significantly higher improvement than the control group. Our results therefore suggest that this new specific method with PosturalSpine® D'Amanti method could play a significant role in improving adolescent idiopathic scoliosis compared to traditional exercises.

该研究的目的是比较采用传统技术治疗特发性脊柱侧凸与采用创新方法治疗特发性脊柱侧凸患者(8 - 18岁)的改善结果。该研究包括17名参与者,分为两组:实验组(n = 8)和对照组(n = 9)。第一组采用PosturalSpine®D'Amanti方法治疗,每周2次,每次30分钟;第二组采用运动疗法和传统工具治疗,每周3次,每次45分钟。两组在人体测量特征、基线Risser指数和Cobb角平均值方面相似,两组间无统计学差异。经过一年的运动干预,两个治疗组在脊柱侧弯的进展方面都有改善,而PosturalSpine®组的改善明显高于对照组。因此,我们的研究结果表明,与传统运动相比,这种新的特殊方法与PosturalSpine®D'Amanti方法在改善青少年特发性脊柱侧凸方面发挥了重要作用。
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引用次数: 0
Oxy-inflammation in hyperbaric oxygen therapy applications. 氧炎症在高压氧治疗中的应用。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-01-20 DOI: 10.4081/ejtm.2025.12783
Gerardo Bosco, Andrea Brizzolari, Matteo Paganini, Enrico Camporesi, Alessandra Vezzoli, Simona Mrakic-Sposta

Hyperbaric oxygen therapy (HBOT) is a non-invasive method of O2 delivery that induces systemic hyperoxia. Hyperbaric chamber consists of a pressure vessel and a compressed breathing gas supply, which can regulate internal pressure. The chamber delivers 100% O2 to patients according to predetermined protocols and is monitored by trained personnel. HBOT relies on increasing the inspired O2 fraction (fiO2) and elevating the partial pressure of O2 (pO2). O2 is typically administered at pressures between 1.5 and 3.0 ATA for 60 to 120 minutes, depending on the clinical presentation. Currently, there are 15 indications for HBOT approved by the Undersea and Hyperbaric Medicine Society, categorized into three groups: emergency medicine, wound healing acceleration, and antimicrobial effects. The present narrative review aims to elucidate the mechanisms action underlying HBOT, particularly oxy-inflammation, in various pathologies within these categories.

高压氧治疗(HBOT)是一种诱导全身高氧的无创氧气输送方法。高压室由一个压力容器和一个压缩的呼吸气源组成,可以调节内部压力。腔室根据预定的方案向患者输送100%的氧气,并由训练有素的人员进行监测。HBOT依赖于增加吸入O2分数(fiO2)和提高O2分压(pO2)。根据临床表现,通常在1.5至3.0 ATA的压力下给予氧气60至120分钟。目前,HBOT经海底与高压氧医学学会批准的适应症有15种,分为急诊医学、加速伤口愈合和抗菌三大类。本综述旨在阐明HBOT的作用机制,特别是氧性炎症,在这些类别的各种病理中。
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引用次数: 0
A neurophysiological and genetic assessment of a case of rapidly progressive scoliosis. 对一例快速进展性脊柱侧凸进行神经生理学和遗传学评估。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-12-19 DOI: 10.4081/ejtm.2024.13249
Maria Chiara Maccarone, Matilde Paramento, Edoardo Passarotto, Paola Contessa, Maria Rubega, Emanuela Formaggio, Stefano Masiero

Scoliosis is a three-dimensional spinal deformity characterized by a lateral deviation of at least 10° Cobb, categorized into idiopathic and non-idiopathic forms, caused by identifiable factors like congenital abnormalities, neuromuscular conditions, or genetic syndromes. This case report discusses a 15-year-old girl with growth delay and growth hormone (GH) deficiency who experienced rapid scoliosis progression. Initial evaluations were normal, and electroencephalography (EEG) showed nonspecific alterations, but further assessment revealed a MYH3 gene variant associated with scoliosis, short stature, and distinct facial features. Treatment with a Lyon ARTbrace and tailored exercises stopped curve progression. This case highlights the need for thorough evaluations in atypical AIS cases to uncover potential causes.

脊柱侧凸是一种三维脊柱畸形,其特征是侧偏至少10°Cobb,分为特发性和非特发性形式,由先天性异常、神经肌肉状况或遗传综合征等可识别因素引起。这个病例报告讨论了一个15岁的女孩生长迟缓和生长激素(GH)缺乏谁经历快速脊柱侧凸进展。初步评估正常,脑电图(EEG)显示非特异性改变,但进一步评估显示MYH3基因变异与脊柱侧凸、身材矮小和明显的面部特征相关。使用里昂支架和量身定制的锻炼可以阻止弯曲的进展。该病例强调了对非典型AIS病例进行全面评估以发现潜在病因的必要性。
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引用次数: 0
期刊
European Journal of Translational Myology
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