European Journal of Translational Myology最新文献

The Anterior Cruciate Ligament (ACL) is vital for knee stability, and its rupture is a major orthopedic concern with significant health and economic impacts. Evidence suggests a substantial hereditary component in ACL injury susceptibility, with the COL1A1 rs1800012 (SP1) polymorphism frequently studied but with inconsistent results. To clarify the association between the rs1800012 in COL1A1 and ACL injury risk, this meta-analysis synthesized data from case-control and cohort studies focusing exclusively on ACL injuries. Systematic searches of PubMed, Embase, Web of Science, and Scopus identified studies up to June 2025. Eligible studies included individuals diagnosed with ACL injuries and healthy controls, reporting genotype frequencies for rs1800012. Pooled Odds Ratios (OR) and 95% Confidence Intervals (CI) were calculated for various genetic models using random-effects meta-analysis. Study quality was assessed via the Newcastle-Ottawa Scale, and publication bias and heterogeneity were evaluated. Nine studies (1,171 cases, 2,005 controls) were included. The TT genotype was significantly protective under the recessive model (TT vs. TG+GG: OR = 0.49, 95% CI: 0.25-0.97, p = 0.041), and also in direct genotype comparisons (TT vs. TG: OR = 0.41, 95% CI: 0.21-0.80, p = 0.009). Conversely, the TG genotype increased ACL injuries risk under the overdominant model (TG vs. TT+GG: OR = 1.28, 95% CI: 1.07-1.52, p = 0.006) and when compared to GG (TG vs. GG: OR = 1.24, 95% CI: 1.05-1.48, p = 0.014). No significant associations were observed under the allele contrast (T vs. G: OR = 1.04, 95% CI: 0.90-1.21, p = 0.61) or dominant models (TT+TG vs. GG: OR = 1.15, 95% CI: 0.97-1.37, p = 0.10). Heterogeneity was consistently low, and sensitivity analyses confirmed the robustness of these findings. No evidence of publication bias was detected. This meta-analysis demonstrates genotype-specific effects of rs1800012 on ACL injuries risk: the TT genotype is protective, while the TG genotype confers increased risk.

Objective Facial nerve injury remains a challenging complication of cerebellopontine angle (CPA) tumor surgery, often resulting in prolonged functional impairment. The present study aimed to examine the association between different postoperative rehabilitation strategies and long-term clinical and electrophysiological recovery following facial nerve reconstruction. Methods We conducted a single-center retrospective cohort study including adult patients who underwent CPA tumor resection with intraoperatively confirmed facial nerve injury requiring reconstructive intervention between 2018 and 2023. Based on rehabilitation approaches applied in routine clinical practice, patients were classified into three groups: standard postoperative therapy, standard therapy combined with transcutaneous electrical nerve stimulation (TENS), and a multimodal rehabilitation strategy integrating TENS with targeted pharmacological support. Clinical follow-up extended to 12 months. Facial nerve function was evaluated using the House-Brackmann scale, Yanagihara system, Sunnybrook Facial Grading System, and Facial Disability Index, alongside surface and needle electromyographic parameters. Multivariable analyses were performed to account for demographic, tumor-related, surgical, and baseline functional factors. Results All groups demonstrated progressive improvement in facial nerve function over the follow-up period. Patients receiving rehabilitation protocols that included TENS exhibited greater improvements across clinical grading scales and electrophysiological measures compared with those receiving standard therapy alone. The multimodal rehabilitation group showed the largest magnitude of functional recovery, reflected by improved facial symmetry, voluntary movement, patient-reported physical and social function, and more favorable electromyographic patterns. These associations remained consistent after adjustment for potential confounders. Conclusions In this retrospective cohort, postoperative rehabilitation strategies incorporating electrical stimulation were associated with enhanced functional and electrophysiological recovery after facial nerve reconstruction. Multimodal rehabilitation approaches may offer added translational value in clinical neurorehabilitation following CPA tumor surgery. Prospective studies are warranted to further refine and validate optimized rehabilitation protocols.

Diurnal strength fluctuations and the effects of time-of-day-specific training are well-documented in young adults but unclear in elderly women. This study investigated the effects of time-of-day-specific concurrent resistance-aerobic training on muscle strength, bone mass, and functional performance in elderly women. Twenty-six women (65-85 years) were randomized into morning (MTG), afternoon (ATG) and control (CON) groups. Training groups completed 12 weeks of concurrent resistance-aerobic training (3 sessions/week, factor of time). Outcomes included maximal knee extension torque (measured AM/PM, factor of test time), bone mineral density (DXA), and functional tests (30-s chair stand, Five Times Sit-to-Stand and Maximal gait speed). Analysis of strength confirmed a preserved diurnal rhythm, with morning performance deficit present (test time: p=0.0129). The group and time factors interaction approached significance (p=0.0624), further test showed that only ATG differed significantly from the CON, with broader improvement than MTG. The functional performance significantly improved in all tests (p<0.0001, p=0.0002, p=0.0200, respectively) compared to baseline, with no difference between groups. The bone mass parameters remained unchanged. The time-of-day-specific concurrent training improved strength and functional performance in both training groups with afternoon training producing superior strength gains compared to morning training. Unchanged bone parameters suggest longer interventions might be needed for osteogenic effects.

This study examined the effect of simulated foot fixation on neuromuscular activation and power output during a 30-second isokinetic Wingate-type test in trained cyclists. Sixteen well-trained male cyclists and triathletes completed two randomized crossover trials under distinct pedal-foot interface conditions: fixed-foot, using standard athletic shoes secured to flat pedals with elastic bandage to restrict vertical movement, and free-foot, using standard shoes without fixation. Surface Electromyography (sEMG) was recorded from the vastus lateralis, vastus medialis, rectus femoris, biceps femoris, and tibialis anterior to quantify muscle activation, while an isokinetic ergometer continuously measured mechanical power. Compared with the free-foot condition, simulated fixation produced significantly higher peak power (1365.3 ± 153.5 W vs. 1299.0 ± 150.7 W, p = 0.016, d = 0.68) and mean power (900.6 ± 88.4 W vs. 838.3 ± 98.3 W, p < 0.001, d = 1.35), but also a greater fatigue index (47.8 ± 8.0 % vs. 37.2 ± 8.5 %, p < 0.001, d = 1.25). Integrated EMG (iEMG) values increased across all monitored muscles, particularly in the rectus femoris, biceps femoris, and tibialis anterior, indicating altered neuromuscular coordination and enhanced activation of biarticular and stabilizing muscles. These findings suggest that mechanical stabilization of the foot-pedal interface enhances torque transmission and short-term power generation but concurrently accelerates fatigue development due to elevated neuromuscular and metabolic demands. The results emphasize a trade-off between instantaneous performance gains and fatigue progression, relevant for interpreting Wingate-type tests and optimizing sprint-specific cycling training and equipment configurations.