Wistar-Uis 大鼠的乙醇自愿摄入量和焦虑行为

IF 1.2 4区 心理学 Q3 PSYCHOLOGY, MULTIDISCIPLINARY International Journal of Psychological Research Pub Date : 2024-06-13 eCollection Date: 2024-01-01 DOI:10.21500/20112084.7060
Elizabeth T Mendoza, María Villada, Maria Carolina Velásquez-Martínez
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引用次数: 0

摘要

乙醇是世界上五种与疾病、残疾和死亡相关风险较高的物质之一。焦虑行为与乙醇成瘾行为有关。本研究旨在评估三个焦虑行为不同的品系:野生型品系、焦虑相关行为增加的 "反应型 "品系和焦虑相关行为较少的 "非反应型 "品系。为了评估动物的焦虑程度,在摄入乙醇前和摄入乙醇后的 24 小时内,将动物置于高架迷宫中。在自愿摄入乙醇方案中,动物接触水瓶和乙醇瓶。对40天内每天消耗的液体重量进行登记。结果:所有品系的乙醇消耗量与水消耗量相比都有所增加:野生型:第 8 天;R 型:第 10 天;NR 型:第 31 天。只有野生型菌株的乙醇消耗量减少了张开双臂的次数和百分比。结论:焦虑会导致乙醇消耗量增加,并维持与焦虑相关的行为。
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Voluntary Ethanol Intake and Anxiety Behavior in Wistar-Uis Rats.

Ethanol consumption is among the first five substances with higher risk associated with diseases, disability, and death in the world. Anxiety behavior has been linked to ethanol-addictive conduct. The aim of the present study was to evaluate three strains with differential anxiety behavior: a Wild-type strain; a "Reactive" strain, with an increase in anxiety-related behaviors; and a "Non-Reactive" strain, with lower anxiety-related behaviors, before and after the voluntary consumption of ethanol (10%) protocol. To evaluate anxiety, animals were exposed to the elevated plus-maze 24 h before and after the consumption protocol. On the voluntary consumption of ethanol protocol, the animals were exposed to a water and an ethanol bottle. The weight of the liquid consumed daily for 40 days was registered. Results: all strains increased ethanol vs water consumption: Wild-type: day 8; R: day 10; NR: day 31. Ethanol consumption reduced the number and percentage of open arms entries only on the Wild-type strain. Conclusion: anxiety can predispose to an increase in ethanol consumption and to the maintenance of anxiety-related behaviors.

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来源期刊
International Journal of Psychological Research
International Journal of Psychological Research PSYCHOLOGY, MULTIDISCIPLINARY-
CiteScore
2.30
自引率
9.10%
发文量
22
审稿时长
16 weeks
期刊介绍: The International Journal of Psychological Research (Int.j.psychol.res) is the Faculty of Psychology’s official publication of San Buenaventura University in Medellin, Colombia. Int.j.psychol.res relies on a vast and diverse theoretical and thematic publishing material, which includes unpublished productions of diverse psychological issues and behavioral human areas such as psychiatry, neurosciences, mental health, among others.
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