揭示导致宫颈癌的 HPV 类型

IF 20.5 1区 生物学 Q1 MICROBIOLOGY Nature Microbiology Pub Date : 2024-10-10 DOI:10.1038/s41564-024-01835-2
Fernando Dias Gonçalves Lima, Mariano A. Molina
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引用次数: 0

摘要

大约 50 年前,德国病毒学家 Harald zur Hausen 将宫颈癌的病因归结为人类乳头瘤病毒(HPV)。从那时起,HPV 已被证明可在多个解剖部位致癌,并发现了数百种 HPV 类型,促使人们进一步研究 HPV 的致癌潜力。随着时间的推移,这种病毒诱导的致癌性也在与人类共同进化和分化。例如,大多数致癌人类乳头瘤病毒基因型属于α属的同一进化支系--这些基因型和相关的人类乳头瘤病毒基因型被认为具有潜在致癌性。从流行病学的角度来看,了解 HPV 基因型在浸润性宫颈癌(ICC)中的致癌性是预测 HPV 疫苗接种和筛查计划有效性的关键。为了实现这一目标,在最近发表于《柳叶刀》的一项研究中,Wei 及其同事进行了一项全面的系统综述,以评估在全球和地区层面上可归因于单个 HPV 基因型的 ICC 在人群中所占的比例(称为可归因比例或 AF)。作者分析了对宫颈拭子或活检组织进行HPV基因分型的1174项研究,其中包括来自121个国家的110,000多例HPV阳性ICC病例和2,750,000名宫颈细胞学检查正常的患者。对 ICC 病例和细胞学检查正常者的基因型特异性流行率进行了比较,并计算出了几率比(OR),以显示一个群体与单个 HPV 类型相关的可能性是大还是小。OR值明显高于1的HPV基因型被认为是ICC的因果关系。为了估算地区 AFs,可归因风险来自 ORs 并乘以地区 HPV 基因型特异性流行率。全球AFs是根据每个地区的ICC病例数对地区AFs进行加权后估算得出的。然后,作者使用贝叶斯模型生成 AF 估计值,同时考虑 ICC 中的 HPV 感染率和 ORs,并提供 95% 可信区间(贝叶斯模型类似于置信区间)。
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Uncovering the HPV types causing cervical cancer
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来源期刊
Nature Microbiology
Nature Microbiology Immunology and Microbiology-Microbiology
CiteScore
44.40
自引率
1.10%
发文量
226
期刊介绍: Nature Microbiology aims to cover a comprehensive range of topics related to microorganisms. This includes: Evolution: The journal is interested in exploring the evolutionary aspects of microorganisms. This may include research on their genetic diversity, adaptation, and speciation over time. Physiology and cell biology: Nature Microbiology seeks to understand the functions and characteristics of microorganisms at the cellular and physiological levels. This may involve studying their metabolism, growth patterns, and cellular processes. Interactions: The journal focuses on the interactions microorganisms have with each other, as well as their interactions with hosts or the environment. This encompasses investigations into microbial communities, symbiotic relationships, and microbial responses to different environments. Societal significance: Nature Microbiology recognizes the societal impact of microorganisms and welcomes studies that explore their practical applications. This may include research on microbial diseases, biotechnology, or environmental remediation. In summary, Nature Microbiology is interested in research related to the evolution, physiology and cell biology of microorganisms, their interactions, and their societal relevance.
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