Junyi Ren, Kuai Ma, Xiangheng Lu, Haoyu Peng, Jia Wang, Moussa Ide Nasser, Chi Liu
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引用次数: 0
摘要
人们发现了一种新的外周辅助性 T 细胞（Tph）群体，它们是各种自身免疫性疾病的诱因。Tph 细胞能分泌白细胞介素-21（IL-21）、干扰素（IFN）和 C-X-C motif 趋化因子配体 13（CXCL13），从而缓解肾脏疾病。此外，Tph 细胞能大量聚集并浸入发炎组织。与Tfh细胞相比，Tph细胞高表达程序性细胞死亡蛋白1（PD-1）、主要组织相容性复合体II（MHC-II）、C-C趋化因子受体2（CCR2）和C-C趋化因子受体5（CCR5），但往往缺乏趋化因子受体C-X-C趋化因子受体5（CXCR5）的表达。它们显示出与其他 T 细胞不同的特征，在病理发炎的非淋巴组织中促进 B 细胞的反应和抗体生成，是 Tph 细胞的一个独特特征。在这篇综述中，我们总结了 Tph 细胞在慢性肾病、急性肾损伤、肾移植和各种肾病中的作用的最新发现。
Occurrence and role of Tph cells in various renal diseases.
A new population of peripheral helper T (Tph) cells has been identified and contributed to various autoimmune diseases. Tph cells can secrete interleukin-21 (IL-21), interferon (IFN) and C-X-C motif chemokine ligand 13 (CXCL13) to moderate renal disease. Moreover, Tph cells can congregate in huge numbers and immerse within inflamed tissue. Compared to Tfh cells, Tph cells express high programmed cell death protein 1 (PD-1), major histocompatibility complex II (MHC-II), C-C chemokine receptor 2 (CCR2) and C-C chemokine receptor 5 (CCR5) but often lack expression of the chemokine receptor C-X-C chemokine receptor 5 (CXCR5). They display features distinct from other T cells, which are uniquely poised to promote responses and antibody production of B cells within pathologically inflamed non-lymphoid tissues and a key feature of Tph cells. In this review, we summarize recent findings on the role of Tph cells in chronic kidney disease, acute kidney injury, kidney transplantation and various renal diseases.
期刊介绍：
Molecular Medicine is an open access journal that focuses on publishing recent findings related to disease pathogenesis at the molecular or physiological level. These insights can potentially contribute to the development of specific tools for disease diagnosis, treatment, or prevention. The journal considers manuscripts that present material pertinent to the genetic, molecular, or cellular underpinnings of critical physiological or disease processes. Submissions to Molecular Medicine are expected to elucidate the broader implications of the research findings for human disease and medicine in a manner that is accessible to a wide audience.
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