按基线恶化率分列的美国医疗保险非囊性纤维化支气管扩张症患者的生存结果。

IF 2.3 Q2 RESPIRATORY SYSTEM Pulmonary Therapy Pub Date : 2024-12-01 Epub Date: 2024-10-10 DOI:10.1007/s41030-024-00275-x

Joseph Feliciano, Benjamin Lewing, Maitreyee Mohanty, Melanie Lauterio, Sebastian Fucile, Joseph Tkacz, Alan F Barker

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引用次数: 0

摘要

导言：有关非囊性纤维化支气管扩张症（NCFBE）患者疗效的实际数据非常有限。本研究根据基线恶化率评估了非囊性纤维化支气管扩张症患者的临床特征和存活率：支气管扩张症患者（≥1次住院或≥2次门诊索赔中包含支气管扩张症诊断代码，或1次门诊索赔中包含支气管扩张症代码和胸部计算机断层扫描）来自100%医疗保险付费服务数据库（2014年1月-2020年12月）。患者在索引前（基线）和索引后（随访）连续注册时间≥ 12 个月，索引为随机支气管扩张索赔，且支气管扩张病史≥ 12 个月。囊性纤维化患者除外。根据基线期间的病情加重情况对患者进行分层（0、1 或≥ 2）。评估随访加重率和全因死亡率。对照组采用多步骤直接匹配法确定。通过 Kaplan-Meier 分析法估算了从发病到死亡的时间：结果：病情加重分析包括 92,529 例 NCFBE 患者和 92,529 例匹配对照。病情恶化很常见（43%的患者病情恶化≥1次），基线病情恶化较多的患者在随访期间病情恶化≥2次的可能性更大（基线病情恶化为0、1和≥2次的患者分别占11.4%、24.2%和46.8%）。生存分析包括 110,298 名 NCFBE 患者和 110,298 名对照组患者。基线病情加重次数越多的患者死亡时间越短（P 结论：基线病情加重次数越多的患者死亡时间越短）：在这些 NCFBE 患者中，病情加重很常见。病情加重史与未来病情加重和全因死亡率增加有关。

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Survival Outcomes in US Medicare Patients with Non-Cystic Fibrosis Bronchiectasis by Rate of Baseline Exacerbations.

Introduction: There are limited real-world data on outcomes in patients with non-cystic fibrosis bronchiectasis (NCFBE). This study assessed clinical characteristics and survival in patients with NCFBE by baseline exacerbation rate.

Methods: Patients with bronchiectasis (≥ 1 inpatient or ≥ 2 outpatient claims with a bronchiectasis diagnosis code, or one outpatient claim with bronchiectasis code and a chest computed tomography scan) were from the 100% Medicare Fee-for-Service database (Jan 2014-Dec 2020). Patients had continuous enrollment ≥ 12 months pre-index (baseline) and post-index (follow-up), with index a random bronchiectasis claim preceded by ≥ 12 months bronchiectasis history. Patients with cystic fibrosis were excluded. Patients were stratified by exacerbations during baseline (0, 1, or ≥ 2). Follow-up exacerbation rate and all-cause mortality were assessed. Controls were identified using a multistep direct matching approach. Time to death from index was estimated by Kaplan-Meier analyses.

Results: Exacerbation analysis included 92,529 patients with NCFBE and 92,529 matched controls. Exacerbations were common (43% had ≥ 1 exacerbation), with patients with more baseline exacerbations more likely to have ≥ 2 exacerbations during follow-up (11.4%, 24.2%, and 46.8% of patients with 0, 1, and ≥ 2 baseline exacerbations, respectively). Survival analysis included 110,298 patients with NCFBE and 110,298 controls. Time to death was shorter in patients with more baseline exacerbations (P < 0.0001). Five-year survival was 55.3%, 62.6%, and 65.4% for patients with ≥ 2, 1, and 0 baseline exacerbations, respectively, compared with 64.1% for controls.

Conclusions: In these patients with NCFBE, exacerbations were common. History of exacerbations was associated with future exacerbations and increased all-cause mortality.

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来源期刊

Pulmonary Therapy Medicine-Pulmonary and Respiratory Medicine

CiteScore

5.20

自引率

3.30%

发文量

审稿时长

6 weeks

期刊介绍： Aims and Scope Pulmonary Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from pre-clinical, clinical (all phases), observational, real-world, and health outcomes research around the use of pulmonary therapies, devices, and surgical techniques. Areas of focus include, but are not limited to: asthma; chronic obstructive pulmonary disease; idiopathic pulmonary fibrosis; pulmonary hypertension; cystic fibrosis; lung cancer; respiratory tract disorders; allergic rhinitis and other respiratory allergies; influenza, pneumococcal infection, respiratory syncytial virus and other respiratory infections; and inhalers and other device therapies. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Pulmonary Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of pulmonary therapies. Open Access All articles published by Pulmonary Therapy are open access. Personal Service The journal’s dedicated in-house editorial team offer a personal “concierge service” meaning authors will always have an editorial contact able to update them on the status of their manuscript. The editorial team check all manuscripts to ensure that articles conform to the most recent COPE, GPP and ICMJE publishing guidelines. This supports the publication of ethically sound and transparent research. 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