鼻腔喷雾剂对过敏性鼻炎疗效的研究

Ayten Güner Atayoğlu, Nuray Bayar Muluk, Rahime Koca, İbrahim Çukurova, Erdem Atalay Çetinkaya, Özgür Yörük, Cengiz Bal, Arzu Tatar, Nihat Susaman, Nagehan Dilşad Erdoğmuş Küçükcan, Enes Güngör, Necdet Özçelik, Elvin Alaskarov, Zeynel Öztürk, Oğuzhan Oğuz, Burak Mustafa Taş, Cemal Cingi
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引用次数: 0

摘要

研究目的我们研究了不同类型的鼻腔冲洗喷雾剂对成年过敏性鼻炎(AR)患者的疗效。方法1700名过敏性鼻炎患者(866名男性和834名女性)被分配到以下组别:第二组:含藻类高渗鼻腔喷雾组(n = 600)(Sinomarin Plus Algae ENT);第三组:等渗生理盐水鼻腔喷雾组(n = 500)。所有患者都接受了耳鼻喉科检查,继续接受标准的 AR 治疗,并额外接受指定的鼻腔喷雾剂(每个鼻孔喷 1 次,每天 3 次,持续 3 周)。在治疗前后对过敏症状评分、鼻甲检查、症状总评分和生活质量(QoL)评分进行了评估。结果显示治疗后,第 1 组和第 2 组的症状评分、鼻甲颜色和水肿、症状总评分和 QoL 评分均有所上升(P < .05)。生理盐水组的症状评分和症状总评分在治疗后无显著差异,但鼻甲颜色和水肿值在治疗后有所改善。治疗后 QoL 评分有所提高。比较三组患者,第 1 组和第 2 组的症状总评分明显低于生理盐水组,而第 1 组和第 2 组的 QoL 评分则明显高于生理盐水组。第 1 组和第 2 组之间没有明显差异。结论在标准 AR 治疗中添加含藻高渗鼻腔喷雾剂可提高患者的生活质量,降低症状总分。
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Investigation of the Effectiveness of Nasal Sprays in Allergic Rhinitis.

Objectives: We investigated the effectiveness of different types of nasal irrigation sprays in adult allergic rhinitis (AR) patients. Methods: A total of 1700 patients with AR (866 males and 834 females) were assigned to: Group 1: Hypertonic nasal spray group (n = 600) (Sinomarin® hypertonic nasal spray); Group 2: Algae-containing hypertonic nasal spray group (n = 600) (Sinomarin Plus Algae ENT); and Group 3: Isotonic saline nasal spray group (n = 500). All patients underwent an otolaryngological examination, continued their standard AR treatment, and received the assigned nasal spray additionally (1 spray to each nostril, 3 times a day, for 3 weeks). Allergic symptom scores, turbinate examination, total symptom scores, and quality of life (QoL) scores were evaluated during pre- and post-treatment periods. Results: In groups 1 and 2, symptom scores and turbinate color and edema, total symptom scores, and QoL scores increased after treatment (P < .05). In the saline group, there were no significant differences in symptom scores and total symptom scores after treatment; however, improvement was detected in turbinate color and edema values after treatment. QoL scores increased after treatment. When comparing the 3 groups, the total symptom scores of groups 1 and 2 were significantly lower, and the QoL scores of groups 1 and 2 were considerably higher than those of the saline group. There were no significant differences between groups 1 and 2. Conclusion: Algae-containing and hypertonic nasal spray may be added to the standard AR treatment to increase QoL and decrease total symptom scores.

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