低收入国家目前对出血性疾病的诊断。

Deepak K Mishra, Asish Rath, Mayur Parihar, Sushant S Vinarkar, Anirban Kundu
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摘要

出血性疾病的诊断和治疗取得了长足的进步。但在资源有限的低收入和中低收入国家(LMICs),情况仍然不容乐观。在低中等收入国家,75% 的遗传性出血性疾病患者得不到诊断。在资源有限的情况下,传染病和恶性肿瘤成为主要关注点。在低收入和中等收入国家,出血性疾病没有得到优先考虑,这导致诊断不足和治疗效果不佳。目前面临着各种挑战,如财政状况、医疗基础设施不足、缺乏患者登记册以及医务人员、普通民众和政府利益相关者缺乏相关意识。此外,缺乏熟练的实验室人员和实验室基础设施来对出血性疾病进行最佳诊断,也加剧了这一问题。世界血友病联合会(WFH)一直站在制定战略的前沿,以克服其中的一些不足;然而,包括患者、医疗专业人员和政策制定者在内的利益相关者更积极的参与是当务之急。本综述强调了低收入与中等收入国家在诊断出血性疾病方面面临的不同挑战、高收入国家与低收入与中等收入国家之间的差距以及缩小差距的可能策略。
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Current Diagnosis of Bleeding Disorders in Lower Income Countries.

There have been considerable advances in diagnosing and treating bleeding disorders. But the scenario remains dismal in resource-constrained settings in low and lower-middle-income countries (LMICs). Seventy-five percent of the patients with inherited bleeding disorders do not get diagnosed in LMICs. In resource-constrained settings, infectious disease and malignancies take the major focus. Bleeding disorders do not get prioritised in LMICs, and this leads to underdiagnoses and suboptimal treatment. There are various challenges like financial status, inadequacy of health care infrastructure, lack of patient registry and lack of awareness across medical staff, general population and government stakeholders. The lack of skilled laboratory personnel and laboratory infrastructure for optimal bleeding disorder diagnosis adds on to the problem. World Federation of Hemophilia (WFH) has been at the forefront in developing strategies to overcome some of these inadequacies; however, more active participation of the stakeholders including patients, medical professionals and policy makers is the need of the hour. This review highlights the different challenges in LMICs in diagnosing bleeding disorders, the gap between high-income countries and LMICs and the possible strategies in closing the gap.

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