{"title":"鼠李糖乳杆菌 SDSP202418 对小鼠运动所致疲劳的缓解作用","authors":"Yang Yang, Yuanji Zhao, Huan Lei","doi":"10.3389/fmicb.2024.1420872","DOIUrl":null,"url":null,"abstract":"<p><p>In this study, the effects of <i>Lactobacillus rhamnosus</i> SDSP202418 isolated from shrimp paste on the exercise performance of fatigued mice were analyzed, and the potential action mechanism was revealed. <i>L. rhamnosus</i> SDSP202418 significantly improved the exhaustion time of the mice and regulated the biochemical indices (lactate dehydrogenase, nitrogen, and uric acid) of the fatigued mice to resist fatigue. <i>L. rhamnosus</i> SDSP202418 also upregulated the mRNA expression of slow muscle fibers and downregulated the mRNA expression of fast muscle fibers in the exercise mice by activating the AMPK/PGC-1α pathway in the fatigued mice. It also increased the contents of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH)) in the liver and muscle. These enzymes removed and repaired oxidative free radicals to achieve antifatigue. In addition, <i>L. rhamnosus</i> SDSP202418 can change the gut microbial structure and modulate the abundance and balance of fatigue-related gut microbiota, which in turn exerts antifatigue effects. <i>L. rhamnosus</i> SDSP202418 is a functional food component that relieves fatigue after exercise.</p>","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464290/pdf/","citationCount":"0","resultStr":"{\"title\":\"Alleviating effect of <i>Lactobacillus rhamnosus</i> SDSP202418 on exercise-induced fatigue in mice.\",\"authors\":\"Yang Yang, Yuanji Zhao, Huan Lei\",\"doi\":\"10.3389/fmicb.2024.1420872\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this study, the effects of <i>Lactobacillus rhamnosus</i> SDSP202418 isolated from shrimp paste on the exercise performance of fatigued mice were analyzed, and the potential action mechanism was revealed. <i>L. rhamnosus</i> SDSP202418 significantly improved the exhaustion time of the mice and regulated the biochemical indices (lactate dehydrogenase, nitrogen, and uric acid) of the fatigued mice to resist fatigue. <i>L. rhamnosus</i> SDSP202418 also upregulated the mRNA expression of slow muscle fibers and downregulated the mRNA expression of fast muscle fibers in the exercise mice by activating the AMPK/PGC-1α pathway in the fatigued mice. It also increased the contents of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH)) in the liver and muscle. These enzymes removed and repaired oxidative free radicals to achieve antifatigue. In addition, <i>L. rhamnosus</i> SDSP202418 can change the gut microbial structure and modulate the abundance and balance of fatigue-related gut microbiota, which in turn exerts antifatigue effects. <i>L. rhamnosus</i> SDSP202418 is a functional food component that relieves fatigue after exercise.</p>\",\"PeriodicalId\":12466,\"journal\":{\"name\":\"Frontiers in Microbiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2024-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464290/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3389/fmicb.2024.1420872\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3389/fmicb.2024.1420872","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Alleviating effect of Lactobacillus rhamnosus SDSP202418 on exercise-induced fatigue in mice.
In this study, the effects of Lactobacillus rhamnosus SDSP202418 isolated from shrimp paste on the exercise performance of fatigued mice were analyzed, and the potential action mechanism was revealed. L. rhamnosus SDSP202418 significantly improved the exhaustion time of the mice and regulated the biochemical indices (lactate dehydrogenase, nitrogen, and uric acid) of the fatigued mice to resist fatigue. L. rhamnosus SDSP202418 also upregulated the mRNA expression of slow muscle fibers and downregulated the mRNA expression of fast muscle fibers in the exercise mice by activating the AMPK/PGC-1α pathway in the fatigued mice. It also increased the contents of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH)) in the liver and muscle. These enzymes removed and repaired oxidative free radicals to achieve antifatigue. In addition, L. rhamnosus SDSP202418 can change the gut microbial structure and modulate the abundance and balance of fatigue-related gut microbiota, which in turn exerts antifatigue effects. L. rhamnosus SDSP202418 is a functional food component that relieves fatigue after exercise.
期刊介绍：
Frontiers in Microbiology is a leading journal in its field, publishing rigorously peer-reviewed research across the entire spectrum of microbiology. Field Chief Editor Martin G. Klotz at Washington State University is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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