多通道便携式气味传递装置,用于自我管理和快速气味测试。

Richard Hopper, Daniel Popa, Emanuela Maggioni, Devarsh Patel, Marianna Obrist, Basile Nicolas Landis, Julien Wen Hsieh, Florin Udrea
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摘要

为了加深我们对气味感知的理解,研究人员经常需要在各种环境下对暴露于多种气味的使用者进行实验,包括在诊所和护理院诊断嗅觉丧失。现有的嗅觉测试通常使用多支嗅笔来进行,由高度专业化的护士通过耗时且复杂的测试范式手动呈现给患者。自动气味传递设备(如嗅觉仪系统)虽然存在,但价格昂贵、体积庞大,而且通常是在实验室中进行,因此很难用于现场气味传递。在这里,我们开发了一种便携式、经济实惠的气味传递装置,可通过单独通道传递 24 种气味,时间精确度高,且无交叉污染。该装置通过使用移动应用程序进行数字控制,可以快速、灵活地对气味进行排序,并已在实验室中进行了实验验证,同时还在患者身上进行了测试。该设计为研究嗅觉感知提供了多项优势,并为用户有朝一日在包括家庭在内的各种环境中自行进行嗅觉测试提供了可能性,从而使嗅觉保健服务不断发展,并成为日常实践和自我保健文化的一部分。
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Multi-channel portable odor delivery device for self-administered and rapid smell testing
To improve our understanding of the perception of odors, researchers are often required to undertake experimental procedures with users exposed to multiple odors in a variety of settings, including to diagnose smell loss in clinics and care homes. Existing smell tests are typically administered using multiple sniffing pens, manually presented to patients by a highly specialized nurse using a time-consuming and complex testing paradigm. Automated odor delivery devices, such as olfactometer systems, exist but are expensive, bulky and typically lab based, making them difficult to use for on the ground odor delivery. Here we have developed a portable, affordable, odor delivery device that can deliver 24 odors through individual channels with high temporal precision and without cross-contamination. The device allows for the rapid, flexible sequencing of odors via digital control using a mobile application and has been experimentally validated in the lab, as well as tested on patients. The design provides several advantages for investigating olfactory perception and offers the possibility that users can one day self-administer smell tests in a range of settings, including at home, allowing smell healthcare services to evolve and become part of a routine practice and self-care culture. Richard Hopper and colleagues design a multi-channel odor delivery system. Their device allows high precision olfactory experiences to be created with a compact desktop unit.
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