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Machine learning-facilitated real-time acoustic trapping in time-varying multi-medium environments toward magnetic resonance imaging-guided microbubble manipulation. 机器学习促进时变多介质环境下的实时声捕获,用于磁共振成像引导的微泡操作。
Pub Date : 2026-02-07 DOI: 10.1038/s44172-026-00600-z
Mengjie Wu, Xiaohan Li, Tianquan Tang

Magnetic resonance imaging-guided acoustic trapping is expected to manipulate drug carriers (e.g., microbubbles) within the body, potentially improving carrier concentration at tumor sites and thereby enhancing targeted therapy outcomes. However, accurate trap generation remains challenging due to complex wave propagation through multiple tissue materials. Moreover, respiration-induced tissue motion imposes stringent requirements on computational efficiency for rapid phase updates. Here we propose a machine learning-based model and a closed-loop control scheme to modulate phase patterns rapidly. The model delivers precise time-of-flight prediction (mean err. ≤ 0.24 μs) within 26 ms for 196 transducer elements. In proof-of-concept experiments, computer vision feedback permits fast (about 15 frames per second) position adjustment of a trapped polystyrene ball (Ø2.7 mm). This control scheme helps lessen the ball's spatial drift induced by time-varying multi-medium environments. These experiments on robotic manipulation support our model's potential for future magnetic resonance imaging-guided targeted therapy.

磁共振成像引导的声捕获有望操纵体内的药物载体(如微泡),潜在地提高肿瘤部位的载体浓度,从而提高靶向治疗的效果。然而,由于复杂的波在多种组织材料中的传播,精确的陷阱产生仍然具有挑战性。此外,呼吸诱导的组织运动对快速相位更新的计算效率提出了严格的要求。在这里,我们提出了一个基于机器学习的模型和一个闭环控制方案来快速调制相位模式。该模型提供精确的飞行时间预测(平均误差)。≤0.24 μs),测量范围为26 ms。在概念验证实验中,计算机视觉反馈允许快速(大约每秒15帧)调整捕获的聚苯乙烯球(Ø2.7 mm)的位置。该控制方案有助于减小时变多介质环境引起的球空间漂移。这些关于机器人操作的实验支持了我们的模型在未来磁共振成像引导靶向治疗方面的潜力。
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引用次数: 0
Multi-channel ultrasonic Bessel vortex beams by spatial multiplexing metalens. 空间复用超构透镜的多通道超声贝塞尔涡旋光束。
Pub Date : 2026-02-06 DOI: 10.1038/s44172-026-00599-3
Yinjie Su, Di Wang, Zhongming Gu, Chen Liu, Jie Zhu

The generation of acoustic vortexes sparks intense research interest since they have applications in modern wave-based technologies, such as underwater communication and particle manipulation. However, the existing schemes mainly rely on a phase mask to excite a single vortex beam, thereby lacking the functionality and adaptability for practical scenarios. In this article, we propose a feasible methodology to realize multi-channel ultrasonic Bessel vortex beams at megahertz. By leveraging the concept of spatial multiplexing, the adjacent pixel of the metalens can be assigned to independently generate non-diffraction ultrasonic vortices with different topological charge and spatial orientation, without losing the characteristics of the helicoidal wavefront. We experimentally designed a four-channel metalens with a high fabrication accuracy of 0.2 mm pixel size and measured the far-field ultrasound distribution in the water. Both topological charge and radiation direction of the generated vortices can be precisely controlled as predicted, showcasing great agreement with simulation results with a directional error of less than 1°. Moreover, the intensity of the vortex can be tuned by gradually combining multiple channels into one. The proposed scheme enhances the flexibility of manipulating ultrasonic vortex and offers more possibilities in designing multi-functional ultrasound devices.

声涡的产生引起了人们强烈的研究兴趣,因为它们在现代基于波的技术中有应用,比如水下通信和粒子操纵。然而,现有的方案主要依靠相位掩模来激发单个涡旋光束,缺乏实际应用的功能和适应性。本文提出了一种实现兆赫多通道超声贝塞尔涡旋光束的可行方法。利用空间复用的概念,可以在不失去螺旋波前特性的前提下,分配超构元相邻像元独立产生具有不同拓扑电荷和空间取向的非衍射超声涡流。实验设计了一种制作精度为0.2 mm像素的四通道超构透镜,并测量了水中远场超声分布。所产生的涡旋的拓扑电荷和辐射方向都可以按照预测进行精确控制,与仿真结果非常吻合,方向误差小于1°。此外,可以通过将多个通道逐渐合并为一个通道来调节旋涡的强度。该方案提高了超声旋涡操纵的灵活性,为多功能超声装置的设计提供了更多的可能性。
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引用次数: 0
OpenMetabolics: estimating energy expenditure using a smartphone worn in a pocket. OpenMetabolics:使用口袋里的智能手机估算能量消耗。
Pub Date : 2026-02-06 DOI: 10.1038/s44172-026-00604-9
Haedo Cho, Patrick Slade

Physical inactivity is the fourth largest cause of global mortality. Health organizations have requested a tool to objectively measure physical activity because many specific and causal relationships between activity and health outcomes are not clearly understood. Existing activity monitors are either unsuitable for large-scale use or have substantial error. We present OpenMetabolics, a biomechanically-informed activity monitor that employs a smartphone in a pants pocket which measures leg motion to estimate energy expenditure. OpenMetabolics uses a data-driven machine learning model to capture the relationship between underlying leg muscle activity and energy expended during common physical activities. OpenMetabolics estimated energy expenditure with 18% cumulative error across all real-world activities, approximately two times lower than existing tools. We developed a pocket motion artifact correction model to accurately monitor energy expenditure when the smartphone is in a pocket of various types of clothing. A week-long, at-home monitoring study highlighted individual and population-level activity patterns across various timescales. We have made the data, code, and smartphone application open source. This accurate and accessible activity monitor could be deployed for large-scale studies with many patient populations to relate activity to health outcomes, inform health policy, and develop interventions.

缺乏身体活动是全球第四大死亡原因。卫生组织要求有一种工具来客观地衡量身体活动,因为活动与健康结果之间的许多具体和因果关系尚不清楚。现有的活动监视器要么不适合大规模使用,要么存在很大的误差。我们介绍了OpenMetabolics,这是一种生物力学信息活动监测器,它使用裤子口袋里的智能手机来测量腿部运动来估计能量消耗。OpenMetabolics使用数据驱动的机器学习模型来捕捉普通体育活动中腿部肌肉活动和能量消耗之间的关系。OpenMetabolics在所有实际活动中估计的能量消耗累积误差为18%,比现有工具低约两倍。我们开发了一个口袋运动伪像校正模型,当智能手机放在各种类型的衣服口袋里时,可以准确地监测能量消耗。一项为期一周的家庭监测研究强调了不同时间尺度上个人和人口水平的活动模式。我们已经将数据、代码和智能手机应用程序开源。这种准确、方便的活动监测仪可用于有许多患者群体的大规模研究,将活动与健康结果联系起来,为卫生政策提供信息,并制定干预措施。
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引用次数: 0
High-velocity laser Doppler vibrometry measurements on an aluminum nitride bimorph wedge resonator. 高速激光多普勒振动测量在氮化铝双晶形楔形谐振器。
Pub Date : 2026-02-05 DOI: 10.1038/s44172-026-00595-7
Zihuan Liu, Xiaoyu Niu, Ehsan Vatankhah, Yuqi Meng, Seunghwi Kim, Ruochen Lu, Andrea Alù, Neal A Hall

Recent advances in microelectromechanical systems (MEMS) have advanced inertial sensor technology. For resonant gyroscopes, sensitivity scales with the maximum velocity of the resonating mass, as higher velocities amplify the Coriolis force for faster and more accurate inertial signal detection-critical in navigation applications. Conventional MEMS remain in linear regimes, with velocities typically below 5 m/s. A recent Defense Advanced Research Projects Agency (DARPA) initiative challenges researchers to push resonator speeds toward material fracture limits, targeting up to 200 m/s and exploring regimes dominated by strong nonlinearities. This work investigates velocity limits in piezoelectrically driven mechanical resonators imposed by nonlinear dynamics and material constraints. We experimentally demonstrate an AlN bimorph wedge resonator reaching 50 m/s, achieving a ten-fold improvement over current limits. These results highlight the feasibility of operating MEMS devices at much higher velocities, paving the way for next-generation inertial sensors with increased performance. The resonator operates at a higher-order mode near 1.81 MHz, with clear evidence of Duffing-type nonlinearities at large drive amplitudes, as confirmed in time-domain and frequency-domain measurements.

近年来,微机电系统(MEMS)发展了先进的惯性传感器技术。对于共振陀螺仪,灵敏度随共振质量的最大速度而变化,因为更高的速度会放大科里奥利力,从而更快、更准确地检测惯性信号——这在导航应用中是至关重要的。传统的MEMS保持在线性状态,速度通常低于5米/秒。最近,美国国防部高级研究计划局(DARPA)发起了一项挑战,要求研究人员将谐振器的速度推向材料断裂极限,目标是高达200米/秒,并探索由强非线性主导的机制。这项工作研究了非线性动力学和材料约束下压电驱动机械谐振器的速度限制。我们通过实验证明了AlN双晶片楔形谐振器达到50 m/s,在电流限制上实现了十倍的改进。这些结果强调了在更高速度下操作MEMS器件的可行性,为性能更高的下一代惯性传感器铺平了道路。谐振器工作在1.81 MHz附近的高阶模式下,在大驱动幅值处具有明显的duffing型非线性,这在时域和频域测量中得到了证实。
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引用次数: 0
Ultra-stable speckle-based optical fiber sensing demonstrated on an uncrewed aerial vehicle platform. 基于散斑的超稳定光纤传感在无人飞行器平台上的演示。
Pub Date : 2026-02-05 DOI: 10.1038/s44172-026-00603-w
Przemyslaw Falak, Toby King-Cline, Akos Maradi, Timothy Lee, Bruno Moog, Pawel Maniewski, Robert Entwistle, Martynas Beresna, Christopher Holmes

Speckle-pattern interrogation offers a route to high-resolution spectral sensing, but its uptake has been constrained by poor temporal stability under real-world conditions. Here, we introduce an ultra-stable speckle-based architecture that overcomes these limitations and enables real-time structural health monitoring of uncrewed aerial vehicles. Unlike conventional approaches that rely on large-scale, free-space passive speckle decorrelation, our system utilizes an ultra-compact speckle pattern via laser-written scattering centers in a high aspect ratio flat fiber, encapsulated within a 3D-printed polylactide housing. This architecture suppresses environmental drift and enables robust, high-fidelity interrogation of fiber Bragg gratings in dynamic aerospace conditions. The system demonstrated exceptional stability under sustained mechanical excitation, maintaining measurement integrity at ±7 G sinusoidal acceleration along the axial direction. Furthermore, in-flight validation across uncrewed aerial vehicle flight tests confirmed real-time strain interrogation in the -100-400 µε range with a standard deviation in measurement of 1.63 µε. These results mark the demonstration of stable, real-time speckle-based interrogation in flight, establishing a path toward broader deployment of specklemeters in harsh environments.

斑点模式探测为高分辨率光谱传感提供了一条途径,但它的吸收受到现实条件下较差的时间稳定性的限制。在这里,我们介绍了一种超稳定的基于斑点的架构,克服了这些限制,实现了无人驾驶飞行器的实时结构健康监测。与依赖于大规模、自由空间被动散斑去相关的传统方法不同,我们的系统通过激光写入高纵横比平面光纤中的散射中心,利用超紧凑的散斑图案,封装在3d打印的聚乳酸外壳中。这种结构抑制了环境漂移,使光纤布拉格光栅在动态航空航天条件下具有鲁棒性和高保真度。该系统在持续的机械激励下表现出优异的稳定性,在沿轴向±7g正弦加速度下保持测量完整性。此外,在无人飞行器飞行测试中进行的飞行验证证实了-100-400 μ ε范围内的实时应变询问,测量标准偏差为1.63 μ ε。这些结果标志着在飞行中稳定、实时的基于斑点的探测,为在恶劣环境中更广泛地部署斑点仪开辟了道路。
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引用次数: 0
Dimensionality reduced antenna array for beamforming/steering. 用于波束形成/转向的降维天线阵列。
Pub Date : 2026-02-03 DOI: 10.1038/s44172-026-00588-6
Shiyi Xia, Mingyang Zhao, Qian Ma, Xunnan Zhang, Ling Yang, Yazhi Pi, Hyunchul Chung, Fuchang Li, Ad Reniers, A M J Koonen, Zizheng Cao

Targeted communication is made possible using beamforming. It is extensively employed in many disciplines involving electromagnetic waves, including arrayed ultrasonic, optical, and high-speed wireless communication. Conventional beam steering often requires the addition of separate active amplitude and phase control units after each radiating element. The high-power consumption and complexity of large-scale phased arrays can be overcome by reducing the number of active controllers, pushing beamforming into satellite communications and deep space exploration. To address this, we propose a phased array antenna design based on dimensionality-reduced cascaded angle offset phased array (DRCAO-PAA). By applying singular value decomposition (SVD) to compress the coefficient matrix of phase shifts, our method reduces the number of active controllers while maintaining beam-steering performance. Furthermore, the suggested DRCAO-PAA was sing the singular value deposition concept. For practical application the particle swarm optimization algorithm and deep neural network Transformer were adopted. Based on this theoretical framework, an experimental board was built to verify the theory. Finally, the 16/8/4 -array beam steering was demonstrated by using 4/3/2 active controllers, respectively.

使用波束成形使目标通信成为可能。它广泛应用于许多涉及电磁波的学科,包括阵列超声波、光学和高速无线通信。传统的波束控制通常需要在每个辐射单元之后添加单独的主动振幅和相位控制单元。大规模相控阵的高功耗和复杂性可以通过减少主动控制器的数量来克服,将波束成形推向卫星通信和深空探索。为了解决这个问题,我们提出了一种基于降维级联角偏移相控阵(DRCAO-PAA)的相控阵天线设计。该方法采用奇异值分解(SVD)压缩相移系数矩阵,在保持波束控制性能的同时减少了主动控制器的数量。此外,建议的DRCAO-PAA采用奇异值沉积概念。在实际应用中,采用了粒子群优化算法和深度神经网络变压器。在此理论框架的基础上,搭建了实验板对理论进行验证。最后,分别用4/3/2个有源控制器演示了16/8/4阵列的波束控制。
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引用次数: 0
Harnessing synthetic biology for energy-efficient bioinspired electronics: applications for logarithmic data converters. 利用合成生物学节能生物启发电子学:对数数据转换器的应用。
Pub Date : 2026-02-02 DOI: 10.1038/s44172-026-00589-5
Ilan Oren, Vishesh Gupta, Mouna Habib, Yizhak Shifman, Joseph Shor, Loai Danial, Ramez Daniel

Neuronal networks have driven advances in artificial intelligence, while molecular networks can provide powerful frameworks for energy-efficient information processing. Inspired by biological principles, we present a computational framework for mapping synthetic gene circuits into bio-inspired electronic architectures. In particular, we developed logarithmic Analog-to-Digital Converter (ADC), operating in current mode with a logarithmic encoding scheme, compresses an 80 dB dynamic range into three bits while consuming less than 1 µW, occupying only 0.02 mm², and operating at 4 kHz. Our bio-inspired approach achieves linear scaling of power, unlike conventional linear ADCs where power consumption increases exponentially with bit resolution, significantly improving efficiency in resource-constrained settings. Through a computational trade-off analysis, we demonstrate that logarithmic encoding maximizes spatial resource efficiency among power consumption and computational accuracy. By leveraging synthetic gene circuits as a model for efficient computation, this study provides a platform for the convergence of synthetic biology and bio-inspired electronic design.

神经网络推动了人工智能的进步,而分子网络可以为节能信息处理提供强大的框架。受生物学原理的启发,我们提出了一个计算框架,用于将合成基因电路映射到生物启发的电子结构中。特别是,我们开发了对数模数转换器(ADC),工作在电流模式下,采用对数编码方案,将80 dB动态范围压缩为3位,功耗小于1 μ W,占地面积仅为0.02 mm²,工作频率为4 kHz。我们的仿生方法实现了功率的线性缩放,不像传统的线性adc,功耗随着位分辨率呈指数级增长,显著提高了资源受限环境下的效率。通过计算权衡分析,我们证明对数编码在功耗和计算精度之间最大化空间资源效率。通过利用合成基因电路作为高效计算的模型,本研究为合成生物学和生物启发电子设计的融合提供了一个平台。
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引用次数: 0
Adaptive hierarchical learning for uncertainty-aware distributed energy resource planning. 不确定性感知分布式能源规划的自适应分层学习。
Pub Date : 2026-01-23 DOI: 10.1038/s44172-026-00591-x
Yue Xiang, Lingtao Li, Yu Lu, Alexis Pengfei Zhao, Youbo Liu, Xinying Wang, Tianjiao Pu, Chenghong Gu, Junyong Liu

The proliferation of distributed energy resources introduces multi-source uncertainties, including implicit uncertainties arising from third-party operators' partial observability of security constraints, challenging traditional distribution network planning methods dependent on model simplification and predefined scenarios. We address this gap via an adaptive hierarchical learning architecture that co-optimizes distributed energy resources location, capacity, and operational strategies data-drivenly, enabling autonomous learning of implicit constraints without full model knowledge. Our framework embeds a bi-level Stackelberg structure where Monte Carlo Tree Search autonomously generates planning schemes at the upper level, while multi-agent reinforcement learning directly learns operational policies from real-time data at the lower level under partial observability. Validation on both benchmark and large-scale practical distribution systems shows lower investment costs and faster solutions while maintaining voltage stability, demonstrating superior scalability and adaptiveness to implicit uncertainties versus scenario-based methods.

分布式能源的激增引入了多源不确定性,其中包括第三方运营商对安全约束的部分可观察性带来的隐性不确定性,这对传统的依赖于模型简化和预定义场景的配电网规划方法提出了挑战。我们通过自适应分层学习架构来解决这一差距,该架构以数据驱动的方式共同优化分布式能源资源的位置、容量和运营策略,从而在没有完整模型知识的情况下实现隐式约束的自主学习。我们的框架嵌入了一个双层Stackelberg结构,其中蒙特卡罗树搜索在上层自主生成规划方案,而多智能体强化学习在部分可观察性下直接从底层的实时数据中学习操作策略。在基准和大规模实际配电系统上的验证表明,在保持电压稳定的同时,投资成本更低,解决方案更快,与基于场景的方法相比,展示了卓越的可扩展性和对隐含不确定性的适应性。
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引用次数: 0
Cyber metasurface system for electromagnetic field closed-loop sensing and manipulation. 面向电磁场闭环传感与操纵的网络超表面系统。
Pub Date : 2026-01-23 DOI: 10.1038/s44172-026-00593-9
Xingqi Xuan, Bincai Wu, Yuqi Chen, Wangjie Cen, Yulin Zhou, Shilie Zheng, Xiaonan Hui, Xianmin Zhang

Intelligent metasurfaces, capable of shaping the electromagnetic field, have been extensively investigated in diverse scenarios, including beamforming, wireless communication, and electromagnetic imaging. Adaptable metasurface control is essential for their applications in practical communications engineering. Here we present a cyber-managed metasurface system to enhance the convenience of metasurface sub-array management, which integrates radio frequency energy harvesting with star-topology hybrid networks. By employing digitized phase-shifted transmission lines as tunable elements, the system not only enables electromagnetic manipulation and sensing capabilities but also achieves ultra-low power consumption. Each metasurface sub-array consists of 2 × 2 units, serving as a network node for data transmission and the sharing of harvested energy. Additionally, these metasurface sub-arrays, designed to resemble LEGO blocks, can be combined into various configurations, enabling flexible electromagnetic manipulation. The cyber-managed metasurface can be seamlessly integrated into wireless communication systems and passive wireless sensing networks, thereby providing versatility across diverse applications.

智能超表面,能够塑造电磁场,已经在各种场景中得到了广泛的研究,包括波束成形,无线通信和电磁成像。自适应超表面控制是其在实际通信工程中应用的必要条件。为了提高元表面子阵列管理的便利性,我们提出了一种网络管理的元表面系统,该系统将射频能量收集与星拓扑混合网络相结合。通过采用数字化相移传输线作为可调谐元件,系统不仅实现了电磁操纵和传感能力,而且实现了超低功耗。每个元表面子阵列由2 × 2单元组成,作为数据传输和能量共享的网络节点。此外,这些设计成类似乐高积木的超表面子阵列可以组合成各种配置,实现灵活的电磁操作。网络管理的超表面可以无缝集成到无线通信系统和无源无线传感网络中,从而提供跨各种应用的多功能性。
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引用次数: 0
Pilot full-scale demonstration of a prototype table-top neutron resonance transmission analysis system for nuclear material detection. 用于核材料探测的台式中子共振透射分析系统原型的中试全尺寸演示。
Pub Date : 2026-01-23 DOI: 10.1038/s44172-025-00564-6
Cebastien Joel Guembou Shouop, Harufumi Tsuchiya

Neutron Resonance Transmission Analysis (NRTA) is a highly sensitive, non-destructive technique for nuclear material characterisation, but its application has been limited by its reliance on large, fixed, and costly installations. Here, we present a compact mobile NRTA system utilising a small 252Cf spontaneous neutron source, designated as a prototype "table-top NRTA system", to analyse nuclear materials, offering a mobile and cost-effective alternative to accelerators or deuterium-tritium generators. The pilot system, measuring 130 cm × 50 cm × 50 cm with a 42 cm flight path, enables time-of-flight measurements on nuclear material samples. The system's performance was demonstrated through NRTA measurements of simulated samples, including indium, hafnium, and cadmium metal plates. The experimental transmission spectra were compared with theoretical predictions using the PHITS Monte Carlo simulation and the JENDL-5 nuclear data library, enabling isotope identification below 5 eV. The obtained results underscore the system's potential as a complementary tool for nuclear security and safeguards verification, particularly in scenarios where access to large accelerator or reactor facilities is impractical, and where mobility, compactness, and cost-effectiveness are prioritised over throughput.

中子共振透射分析(NRTA)是一种高灵敏度、非破坏性的核材料表征技术,但其应用受到大型、固定和昂贵装置的限制。在这里,我们提出了一个紧凑的移动NRTA系统,利用一个小的252Cf自发中子源,被指定为原型“桌面NRTA系统”,分析核材料,提供了一个移动和经济有效的替代加速器或氘-氚发生器。该先导系统尺寸为130厘米× 50厘米× 50厘米,飞行路径为42厘米,可对核材料样品进行飞行时间测量。该系统的性能通过NRTA测量模拟样品,包括铟,铪和镉金属板证明。利用PHITS蒙特卡罗模拟和JENDL-5核数据库将实验透射谱与理论预测进行了比较,实现了5 eV以下的同位素鉴定。获得的结果强调了该系统作为核安全和保障核查的补充工具的潜力,特别是在使用大型加速器或反应堆设施不切实际的情况下,以及机动性、紧凑性和成本效益优先于吞吐量的情况下。
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引用次数: 0
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Communications engineering
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