基于掺杂重元素的生物玻璃 45S5 的辐射敏化剂材料

IF 0.6 4区材料科学 Q4 MATERIALS SCIENCE, CERAMICS Glass and Ceramics Pub Date : 2024-10-02 DOI:10.1007/s10717-024-00680-3

D. N. Grishchenko, O. S. Plotnikova, V. G. Kuryavyi, V. I. Apanasevich, M. A. Medkov

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引用次数: 0

摘要

我们获得了含有 40 wt.%重金属氧化物（Bi、Ta 和 W）的玻璃和玻璃陶瓷，并将其作为放射增敏剂用于医疗领域。对这些复合材料的特性进行了体外研究，包括二次辐射的产生、化学溶解性以及吸收过程中介质 pH 值的变化。结果表明，二次辐射指标和介质的 pH 值依次降低：W > Ta > Bi。溶解度指数依次降低：W > Bi > Ta。基于生物玻璃 45S5 的含 W 陶瓷尽管产生的二次电离辐射最多，但由于其溶解速度快、环境碱化程度高，不适合在体内使用。

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Materials Based on Bioglass 45S5, Doped with Heavy Elements, for Use as Radiosensitizers

Glass and glass ceramics containing 40 wt.% of heavy metal oxides (Bi, Ta, and W) were obtained for use in medicine as radiosensitizers. The properties of the composites were studied in vitro, including the generation of secondary radiation, chemical solubility, and the variations in the pH of the medium during resorption. The results demonstrated that the secondary radiation indicators and pH value of the medium decreased in the order: W > Ta > Bi. Solubility indices decreased in the order: W > Bi > Ta. Despite the highest generation of secondary ionizing radiation, W-containing ceramics based on Bioglass 45S5 are unsuitable for in vivo use due to their rapid dissolution and high alkalization of the environment.

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来源期刊

Glass and Ceramics 工程技术-材料科学：硅酸盐

CiteScore

1.00

自引率

16.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Glass and Ceramics reports on advances in basic and applied research and plant production techniques in glass and ceramics. The journal''s broad coverage includes developments in the areas of silicate chemistry, mineralogy and metallurgy, crystal chemistry, solid state reactions, raw materials, phase equilibria, reaction kinetics, physicochemical analysis, physics of dielectrics, and refractories, among others.