封面：用三唑鎓衍生物制备具有生物活性的赖氨酸和多肽共轭物的合成策略（欧洲有机化学杂志 38/2024）

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC European Journal of Organic Chemistry Pub Date : 2024-10-11 DOI:10.1002/ejoc.202483801

Patrycja Ledwoń, Michał Jewginski, Claudia Bello, Francesca Nuti, Paolo Rovero, Rafal Latajka, Anna Maria Papini

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引用次数: 0

摘要

封面显示的是一组萨菲鎓染料衍生物，通过利用赖氨酸侧链作为染料和肽之间的有效连接物，用于轻松制备肽共轭物，作为潜在的弹性蛋白酶抑制剂。有了构成核心的优化肽序列和作为特殊盖帽的三唑鎓衍生物，我们就能创造出能够调节选定酶活性的分子工具。R. Latajka、A. M. Papini 及合作者的研究文章中报告了这一方法的细节。Papini 及其合作者的研究文章中（DOI: 10.1002/ejoc.202400399）。结构取自 PDB ID：1QR3。

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Front Cover: Synthetic Strategies to Prepare Bioactive Lysine and Peptide Conjugates With Triazolium Derivatives (Eur. J. Org. Chem. 38/2024)

The Front Cover shows a set of Safirinium-dye derivatives used for the facile preparation of peptide conjugates as potential elastase inhibitors, by exploiting a lysine side chain as an effective linker between the dye and the peptide. With an optimized peptide sequence forming the core and triazolium derivatives acting as particular caps, we can create molecular tools capable of tuning the activity of a selected enzyme. Details of this approach are reported in the Research Article by R. Latajka, A. M. Papini and co-workers (DOI: 10.1002/ejoc.202400399). Structure taken from PDB ID: 1QR3.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.