用于放射治疗的基于聚甲基丙烯酸甲酯凝胶 (PMMAG) 的新型 3D 聚合物凝胶剂量计:超声波评估

IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL Radiation Physics and Chemistry Pub Date : 2024-10-09 DOI:10.1016/j.radphyschem.2024.112286
Mohammed Dawood Salman , Yasmin Md Radzi , Azhar Abdul Rahman , Ammar A. Oglat
{"title":"用于放射治疗的基于聚甲基丙烯酸甲酯凝胶 (PMMAG) 的新型 3D 聚合物凝胶剂量计:超声波评估","authors":"Mohammed Dawood Salman ,&nbsp;Yasmin Md Radzi ,&nbsp;Azhar Abdul Rahman ,&nbsp;Ammar A. Oglat","doi":"10.1016/j.radphyschem.2024.112286","DOIUrl":null,"url":null,"abstract":"<div><div>This study investigates the characteristics of a novel polymer gel dosimeter (PMMAG) for radiotherapy applications, focusing on its radiation absorption and sensitivity properties. The PMMAG dosimeters were evaluated using both UV–vis spectrophotometry and ultrasonic techniques. The results of the study, UV–vis analysis revealed a significant increase in dose response with the introduction of a cross-linker, peaking at a monomer-to-cross-linker ratio of 5:3. Sensitivity analysis indicated optimal sensitivity at this ratio, with values reaching 0.021 a.u./Gy. Ultrasound evaluation showed that the speed of sound and attenuation coefficient demonstrated a linear relationship and a strong positive correlation with an increase in the applied radiation dose, with the highest sensitivity observed at 8 Gy. The optimal sample exhibited the highest dose-response values at both 4 Gy and 8 Gy doses. Sensitivity values ranged from 2.1 to 2.75. The ultrasonic measurements demonstrated a significantly larger dynamic range in dose response curves compared to UV–vis dose-response data. It is concluded that ultrasound shows great potential as a technique for the evaluation of polymer gel dosimeters. The PMMAG can be introduced as a novel dosimeter for ionizing radiation dosimetry, validated through both optical and ultrasound assessment methods. The consistent and reliable performance of the PMMAG dosimeters makes them suitable for various applications in radiation therapy.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112286"},"PeriodicalIF":2.8000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A novel 3D polymer gel dosimeter based on polymethyl methacrylate gel (PMMAG) for radiotherapy: Ultrasonic evaluation\",\"authors\":\"Mohammed Dawood Salman ,&nbsp;Yasmin Md Radzi ,&nbsp;Azhar Abdul Rahman ,&nbsp;Ammar A. Oglat\",\"doi\":\"10.1016/j.radphyschem.2024.112286\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This study investigates the characteristics of a novel polymer gel dosimeter (PMMAG) for radiotherapy applications, focusing on its radiation absorption and sensitivity properties. The PMMAG dosimeters were evaluated using both UV–vis spectrophotometry and ultrasonic techniques. The results of the study, UV–vis analysis revealed a significant increase in dose response with the introduction of a cross-linker, peaking at a monomer-to-cross-linker ratio of 5:3. Sensitivity analysis indicated optimal sensitivity at this ratio, with values reaching 0.021 a.u./Gy. Ultrasound evaluation showed that the speed of sound and attenuation coefficient demonstrated a linear relationship and a strong positive correlation with an increase in the applied radiation dose, with the highest sensitivity observed at 8 Gy. The optimal sample exhibited the highest dose-response values at both 4 Gy and 8 Gy doses. Sensitivity values ranged from 2.1 to 2.75. The ultrasonic measurements demonstrated a significantly larger dynamic range in dose response curves compared to UV–vis dose-response data. It is concluded that ultrasound shows great potential as a technique for the evaluation of polymer gel dosimeters. The PMMAG can be introduced as a novel dosimeter for ionizing radiation dosimetry, validated through both optical and ultrasound assessment methods. The consistent and reliable performance of the PMMAG dosimeters makes them suitable for various applications in radiation therapy.</div></div>\",\"PeriodicalId\":20861,\"journal\":{\"name\":\"Radiation Physics and Chemistry\",\"volume\":\"226 \",\"pages\":\"Article 112286\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiation Physics and Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0969806X24007783\",\"RegionNum\":3,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation Physics and Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0969806X24007783","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0

摘要

本研究调查了用于放射治疗的新型聚合物凝胶剂量计(PMMAG)的特性,重点是其辐射吸收和灵敏度特性。使用紫外可见分光光度法和超声波技术对 PMMAG 剂量计进行了评估。研究结果表明,紫外-可见光分析表明,随着交联剂的引入,剂量响应显著增加,在单体与交联剂的比例为 5:3 时达到峰值。灵敏度分析表明,该比例下的灵敏度最佳,达到 0.021 a.u./Gy。超声评估显示,声速和衰减系数呈线性关系,与应用辐射剂量的增加呈强烈的正相关,8 Gy 时的灵敏度最高。最佳样本在 4 Gy 和 8 Gy 剂量下的剂量反应值最高。灵敏度值从 2.1 到 2.75 不等。与紫外可见剂量反应数据相比,超声波测量显示剂量反应曲线的动态范围明显更大。结论是,超声波作为一种评估聚合物凝胶剂量计的技术显示出巨大的潜力。PMMAG 可作为一种新型剂量计用于电离辐射剂量测定,并通过光学和超声评估方法进行验证。PMMAG 剂量计稳定可靠的性能使其适用于放射治疗的各种应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
A novel 3D polymer gel dosimeter based on polymethyl methacrylate gel (PMMAG) for radiotherapy: Ultrasonic evaluation
This study investigates the characteristics of a novel polymer gel dosimeter (PMMAG) for radiotherapy applications, focusing on its radiation absorption and sensitivity properties. The PMMAG dosimeters were evaluated using both UV–vis spectrophotometry and ultrasonic techniques. The results of the study, UV–vis analysis revealed a significant increase in dose response with the introduction of a cross-linker, peaking at a monomer-to-cross-linker ratio of 5:3. Sensitivity analysis indicated optimal sensitivity at this ratio, with values reaching 0.021 a.u./Gy. Ultrasound evaluation showed that the speed of sound and attenuation coefficient demonstrated a linear relationship and a strong positive correlation with an increase in the applied radiation dose, with the highest sensitivity observed at 8 Gy. The optimal sample exhibited the highest dose-response values at both 4 Gy and 8 Gy doses. Sensitivity values ranged from 2.1 to 2.75. The ultrasonic measurements demonstrated a significantly larger dynamic range in dose response curves compared to UV–vis dose-response data. It is concluded that ultrasound shows great potential as a technique for the evaluation of polymer gel dosimeters. The PMMAG can be introduced as a novel dosimeter for ionizing radiation dosimetry, validated through both optical and ultrasound assessment methods. The consistent and reliable performance of the PMMAG dosimeters makes them suitable for various applications in radiation therapy.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Radiation Physics and Chemistry
Radiation Physics and Chemistry 化学-核科学技术
CiteScore
5.60
自引率
17.20%
发文量
574
审稿时长
12 weeks
期刊介绍: Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.
期刊最新文献
Simulation of displacement damage in Si & SiO2 caused by protons Controlled degradation of EPR by natural antioxidant/POSS couples for packaging materials Nanodosimetric study of the γ-ray damage repair model based on the germ cell of Caenorhabditis elegans Effects of ionizing irradiation on biodegradation characteristics of synthetic coal chemical industry wastewater Chitosan coated Yb-doped MnCo ferrite: Tailoring properties via gamma irradiation for contrast agents and sensors
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1