Leopoldine T. Lonkeng , Paul Eckhardt , Borice.T. Tsafack , Robert Forster , Beaudelaire K. Ponou , Rémy B. Teponno , Télesphore B. Nguelefack , Till Opatz , Léon A. Tapondjou
{"title":"Rumex abyssinicus Jacq.的根茎：揭示五种新的蒽醌类化合物（Rumabynosides A-E）并综述其植物化学物质的保肝潜力","authors":"Leopoldine T. Lonkeng , Paul Eckhardt , Borice.T. Tsafack , Robert Forster , Beaudelaire K. Ponou , Rémy B. Teponno , Télesphore B. Nguelefack , Till Opatz , Léon A. Tapondjou","doi":"10.1016/j.phytol.2024.09.004","DOIUrl":null,"url":null,"abstract":"<div><div>Five hitherto unreported anthraquinone glycoside derivatives, rumabynosides <strong>A–E</strong> (<strong>1–5</strong>), along with twenty previously reported compounds, were isolated from the rhizomes of <em>Rumex abyssinicus</em>. Three of these new anthraquinones carried an uncommon substituent (3-hydroxy-3-methylglutaroyl) attached to the sugar moiety. Their structures were elucidated by comprehensive UV, IR, HRESIMS, 1D NMR (<sup>1</sup>H and <sup>13</sup>C NMR) and 2D NMR (HSQC, COSY, HMBC, NOESY) analyses. A literature survey revealed hepatoprotective activities of some of the isolated compounds, thus adding weight to the wide use of this plant against various liver diseases in traditional medicine.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 30-36"},"PeriodicalIF":1.3000,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rhizomes of Rumex abyssinicus Jacq.: Unveiling five new anthraquinones (Rumabynosides A-E) and a review on hepatoprotective potential of its phytochemicals\",\"authors\":\"Leopoldine T. Lonkeng , Paul Eckhardt , Borice.T. Tsafack , Robert Forster , Beaudelaire K. Ponou , Rémy B. Teponno , Télesphore B. Nguelefack , Till Opatz , Léon A. Tapondjou\",\"doi\":\"10.1016/j.phytol.2024.09.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Five hitherto unreported anthraquinone glycoside derivatives, rumabynosides <strong>A–E</strong> (<strong>1–5</strong>), along with twenty previously reported compounds, were isolated from the rhizomes of <em>Rumex abyssinicus</em>. Three of these new anthraquinones carried an uncommon substituent (3-hydroxy-3-methylglutaroyl) attached to the sugar moiety. Their structures were elucidated by comprehensive UV, IR, HRESIMS, 1D NMR (<sup>1</sup>H and <sup>13</sup>C NMR) and 2D NMR (HSQC, COSY, HMBC, NOESY) analyses. A literature survey revealed hepatoprotective activities of some of the isolated compounds, thus adding weight to the wide use of this plant against various liver diseases in traditional medicine.</div></div>\",\"PeriodicalId\":20408,\"journal\":{\"name\":\"Phytochemistry Letters\",\"volume\":\"64 \",\"pages\":\"Pages 30-36\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1874390024001320\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024001320","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Rhizomes of Rumex abyssinicus Jacq.: Unveiling five new anthraquinones (Rumabynosides A-E) and a review on hepatoprotective potential of its phytochemicals
Five hitherto unreported anthraquinone glycoside derivatives, rumabynosides A–E (1–5), along with twenty previously reported compounds, were isolated from the rhizomes of Rumex abyssinicus. Three of these new anthraquinones carried an uncommon substituent (3-hydroxy-3-methylglutaroyl) attached to the sugar moiety. Their structures were elucidated by comprehensive UV, IR, HRESIMS, 1D NMR (1H and 13C NMR) and 2D NMR (HSQC, COSY, HMBC, NOESY) analyses. A literature survey revealed hepatoprotective activities of some of the isolated compounds, thus adding weight to the wide use of this plant against various liver diseases in traditional medicine.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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