{"title":"萜类化合物血清水平与成人代谢综合征及其组成部分的关系","authors":"Jianmei Zhou, Rongfang Zhou, Xiaoling Lv, Jing Zhang, Wei Qiao, Genxiang Mao, Qing Wu","doi":"10.1155/2024/7714151","DOIUrl":null,"url":null,"abstract":"<p><b>Aim:</b> Environmental exposure constitutes a significant determinant in the pathogenesis of metabolic syndrome (MetS). Nevertheless, the contribution of environmental factors to MetS remains ambiguous. The present study was aimed at investigating the correlation between serum terpenes and the risk of MetS in the general population.</p><p><b>Methods:</b> A cross-sectional study was conducted among 1266 individuals from the 2013–2014 National Health and Nutrition Examination Survey (NHANES). Serum terpenes and MetS risk were analyzed using a weighted logistic regression model. Weighted quantile sum (WQS) regression was utilized to explore the relationship between the mixture of serum terpenes and MetS. The restricted cubic spline (RCS) method was employed to assess the dose–response relationship between them. All data and analyses were conducted using the “Survey” package in R software (Version 4.3.2).</p><p><b>Results:</b> The study population, with an average age of 46.82 ± 0.46 years and a body mass index (BMI) of 28.97 kg/m<sup>2</sup>, consisted of 48.15% males and 67.99% Whites. Among the participants, 35.78% were diagnosed with MetS. The weighted logistic regression showed that tertiles of serum levels of <i>α</i>-pinene, <i>β</i>-pinene, and limonene were positively correlated with MetS risk with a OR value of 1.90 (1.14, 3.16), 2.02 (1.23, 3.31), and 2.35 (1.33, 4.13) and elevated triglycerides (TGs) with a OR of 2.36 (1.63, 3.43), 3.51 (2.30, 5.38), and 3.96 (2.55, 6.15) (all <i>p</i><sub>trend</sub> < 0.05). The WQS regression indicated a positive association between serum terpene mixture and MetS risk (OR = 1.65, 95% CI: 1.18–2.3), increased TG (OR = 2.69, 95% CI: 1.94–3.71), and reduced high-density lipoprotein cholesterol (HDL-C) (OR = 1.46, 95% CI: 1.03–2.07) (all <i>p</i><sub>trend</sub> < 0.01). The RCS analysis further supported the dose–response relationship.</p><p><b>Conclusion:</b> This study suggested potential adverse effects of terpene exposure on human health, emphasizing the importance of environmental interventions in maintaining health.</p>","PeriodicalId":13529,"journal":{"name":"Indoor air","volume":"2024 1","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7714151","citationCount":"0","resultStr":"{\"title\":\"Association of Serum Levels of Terpenes With Metabolic Syndrome and Its Components in Adults\",\"authors\":\"Jianmei Zhou, Rongfang Zhou, Xiaoling Lv, Jing Zhang, Wei Qiao, Genxiang Mao, Qing Wu\",\"doi\":\"10.1155/2024/7714151\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Aim:</b> Environmental exposure constitutes a significant determinant in the pathogenesis of metabolic syndrome (MetS). Nevertheless, the contribution of environmental factors to MetS remains ambiguous. The present study was aimed at investigating the correlation between serum terpenes and the risk of MetS in the general population.</p><p><b>Methods:</b> A cross-sectional study was conducted among 1266 individuals from the 2013–2014 National Health and Nutrition Examination Survey (NHANES). Serum terpenes and MetS risk were analyzed using a weighted logistic regression model. Weighted quantile sum (WQS) regression was utilized to explore the relationship between the mixture of serum terpenes and MetS. The restricted cubic spline (RCS) method was employed to assess the dose–response relationship between them. All data and analyses were conducted using the “Survey” package in R software (Version 4.3.2).</p><p><b>Results:</b> The study population, with an average age of 46.82 ± 0.46 years and a body mass index (BMI) of 28.97 kg/m<sup>2</sup>, consisted of 48.15% males and 67.99% Whites. Among the participants, 35.78% were diagnosed with MetS. The weighted logistic regression showed that tertiles of serum levels of <i>α</i>-pinene, <i>β</i>-pinene, and limonene were positively correlated with MetS risk with a OR value of 1.90 (1.14, 3.16), 2.02 (1.23, 3.31), and 2.35 (1.33, 4.13) and elevated triglycerides (TGs) with a OR of 2.36 (1.63, 3.43), 3.51 (2.30, 5.38), and 3.96 (2.55, 6.15) (all <i>p</i><sub>trend</sub> < 0.05). The WQS regression indicated a positive association between serum terpene mixture and MetS risk (OR = 1.65, 95% CI: 1.18–2.3), increased TG (OR = 2.69, 95% CI: 1.94–3.71), and reduced high-density lipoprotein cholesterol (HDL-C) (OR = 1.46, 95% CI: 1.03–2.07) (all <i>p</i><sub>trend</sub> < 0.01). The RCS analysis further supported the dose–response relationship.</p><p><b>Conclusion:</b> This study suggested potential adverse effects of terpene exposure on human health, emphasizing the importance of environmental interventions in maintaining health.</p>\",\"PeriodicalId\":13529,\"journal\":{\"name\":\"Indoor air\",\"volume\":\"2024 1\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7714151\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indoor air\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1155/2024/7714151\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CONSTRUCTION & BUILDING TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indoor air","FirstCategoryId":"93","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/2024/7714151","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CONSTRUCTION & BUILDING TECHNOLOGY","Score":null,"Total":0}
Association of Serum Levels of Terpenes With Metabolic Syndrome and Its Components in Adults
Aim: Environmental exposure constitutes a significant determinant in the pathogenesis of metabolic syndrome (MetS). Nevertheless, the contribution of environmental factors to MetS remains ambiguous. The present study was aimed at investigating the correlation between serum terpenes and the risk of MetS in the general population.
Methods: A cross-sectional study was conducted among 1266 individuals from the 2013–2014 National Health and Nutrition Examination Survey (NHANES). Serum terpenes and MetS risk were analyzed using a weighted logistic regression model. Weighted quantile sum (WQS) regression was utilized to explore the relationship between the mixture of serum terpenes and MetS. The restricted cubic spline (RCS) method was employed to assess the dose–response relationship between them. All data and analyses were conducted using the “Survey” package in R software (Version 4.3.2).
Results: The study population, with an average age of 46.82 ± 0.46 years and a body mass index (BMI) of 28.97 kg/m2, consisted of 48.15% males and 67.99% Whites. Among the participants, 35.78% were diagnosed with MetS. The weighted logistic regression showed that tertiles of serum levels of α-pinene, β-pinene, and limonene were positively correlated with MetS risk with a OR value of 1.90 (1.14, 3.16), 2.02 (1.23, 3.31), and 2.35 (1.33, 4.13) and elevated triglycerides (TGs) with a OR of 2.36 (1.63, 3.43), 3.51 (2.30, 5.38), and 3.96 (2.55, 6.15) (all ptrend < 0.05). The WQS regression indicated a positive association between serum terpene mixture and MetS risk (OR = 1.65, 95% CI: 1.18–2.3), increased TG (OR = 2.69, 95% CI: 1.94–3.71), and reduced high-density lipoprotein cholesterol (HDL-C) (OR = 1.46, 95% CI: 1.03–2.07) (all ptrend < 0.01). The RCS analysis further supported the dose–response relationship.
Conclusion: This study suggested potential adverse effects of terpene exposure on human health, emphasizing the importance of environmental interventions in maintaining health.
期刊介绍：
The quality of the environment within buildings is a topic of major importance for public health.
Indoor Air provides a location for reporting original research results in the broad area defined by the indoor environment of non-industrial buildings. An international journal with multidisciplinary content, Indoor Air publishes papers reflecting the broad categories of interest in this field: health effects; thermal comfort; monitoring and modelling; source characterization; ventilation and other environmental control techniques.
The research results present the basic information to allow designers, building owners, and operators to provide a healthy and comfortable environment for building occupants, as well as giving medical practitioners information on how to deal with illnesses related to the indoor environment.
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