Fatemeh Abbasi, Mohammad Mehdi Haghighat Lari, Gholamreza Reza Khosravi, Elahe Mansouri, Nastaran Payandeh, Alireza Milajerdi
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引用次数: 0
摘要
胃肠道上皮屏障在维持人体健康方面发挥着至关重要的作用。考虑到谷氨酰胺对免疫功能和营养吸收的重要性，本研究旨在探讨补充谷氨酰胺对肠道通透性的影响。本研究遵循了系统综述和荟萃分析的 PRISMA 协议。研究人员在四个数据库（PubMed、Scopus、Web of Science 和 Google Scholar）中进行了系统检索，以确定有关谷氨酰胺补充剂和胃肠道渗透性的临床试验，检索时间截止到 2023 年 4 月。资格标准包括测量补充谷氨酰胺后肠道渗透性的随机安慰剂对照试验。不论语言或发表日期，均纳入研究。数据提取包括研究特点、干预细节和结果。研究质量评估采用 Cochrane 工具，统计分析采用随机效应模型的平均差和标准差。为探讨异质性，还进行了分组分析。系统综述和荟萃分析纳入了1998年至2014年的10项研究，共有352名参与者。干预组共纳入 216 名患者，对照组共纳入 212 名患者。参与者的平均年龄为 46.52 岁。就健康状况而言，参与者患有不同类型的疾病。总体而言，补充谷氨酰胺对肠道渗透性没有明显影响（WMD：-0.00，95% CI -0.04，0.03）。亚组分析显示，剂量超过 30 克/天时，肠道渗透性会明显降低（WMD：-0.01，95% CI -0.10，-0.08）。所有纳入研究的谷氨酰胺补充剂均为口服。荟萃分析表明，在补充谷氨酰胺超过 30 毫克/天且持续时间少于 2 周的情况下，肠道渗透性会显著降低。为了进一步了解谷氨酰胺补充剂对肠道渗透性的影响并提出相关建议，有必要对不同剂量和患者人群进行进一步研究。
A systematic review and meta-analysis of clinical trials on the effects of glutamine supplementation on gut permeability in adults
The gastrointestinal tract's epithelial barrier plays a crucial role in maintaining health. This study aims to investigate the impact of glutamine supplementation on intestinal permeability, considering its importance for immune function and nutrient absorption. The study adhered to the PRISMA protocol for systematic reviews and meta-analyses. A systematic search was performed in four databases (PubMed, Scopus, Web of Science, and Google Scholar) until April 2023 to identify clinical trials on glutamine supplementation and gastrointestinal permeability. Eligibility criteria included randomized placebo-controlled trials measuring gut permeability post-glutamine supplementation. Studies were included regardless of language or publication date. Data extraction involved study characteristics, intervention details, and outcomes. Quality assessment was performed using the Cochrane tool, and statistical analysis utilized mean differences and standard deviations with a random effects model. Subgroup analysis was conducted to explore heterogeneity. The systematic review and meta-analysis included 10 studies from 1998 to 2014 with 352 participants. A total of 216 patients were enrolled in the intervention group, and 212 in the control group. The mean participant age was 46.52 years. The participants had different types of diseases in terms of their health status. Overall, glutamine supplementation did not significantly affect intestinal permeability (WMD: −0.00, 95% CI −0.04, 0.03). Subgroup analysis showed a significant reduction in intestinal permeability with doses over 30g/day (WMD: −0.01, 95% CI −0.10, −0.08). The glutamine supplements were administered orally in all included studies. The meta-analysis demonstrated a significant reduction in intestinal permeability with glutamine supplementation exceeding 30 mg/day for durations of less than 2 weeks. Further investigations with varying dosages and patient populations are warranted to enhance understanding and recommendations regarding glutamine supplementation's effects on gut permeability.
期刊介绍：
Amino Acids publishes contributions from all fields of amino acid and protein research: analysis, separation, synthesis, biosynthesis, cross linking amino acids, racemization/enantiomers, modification of amino acids as phosphorylation, methylation, acetylation, glycosylation and nonenzymatic glycosylation, new roles for amino acids in physiology and pathophysiology, biology, amino acid analogues and derivatives, polyamines, radiated amino acids, peptides, stable isotopes and isotopes of amino acids. Applications in medicine, food chemistry, nutrition, gastroenterology, nephrology, neurochemistry, pharmacology, excitatory amino acids are just some of the topics covered. Fields of interest include: Biochemistry, food chemistry, nutrition, neurology, psychiatry, pharmacology, nephrology, gastroenterology, microbiology
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