不同的牙髓封闭剂及其对牙髓炎症反应的影响:叙述性综述

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Saudi Dental Journal Pub Date : 2024-10-01 DOI:10.1016/j.sdentj.2024.07.014
Mustafa Tariq Mutar, Anas F Mahdee
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引用次数: 0

摘要

有几种因素会直接损伤牙髓。牙髓愈合需要控制炎症,而炎症可以通过专门的医用材料来消除感染和促进牙髓修复。本综述旨在对这些材料进行分类,并确定它们对牙髓组织或分离培养细胞的组织学和分子学影响。此外,我们还试图确定这些材料中哪些可以引发有利的炎症途径,从而引导牙髓反应走向愈合和再生。我们使用了一个数据库(PubMed),搜索策略基于 MeSH 术语。检索对象为 2010 年 1 月至 2023 年 12 月间发表的英文文章,包括有组织学和分子学研究结果的文章。只有 33 篇文章符合我们的纳入标准。几种传统的牙髓封闭剂已被证明可通过牙本质桥的形成诱导牙髓愈合和修复。这些材料表现出不同程度的炎症,从中度到轻度不等,随着时间的推移炎症可能会减轻。此外,还对其他实验开发的材料进行了研究,包括单独使用或与传统产品结合使用;这些材料在减少与传统产品相关的炎症和表皮坏死方面表现出了良好的潜力。不过,它们仍未达到理想牙髓覆盖材料的所有标准,需要进一步开发才能实现商业化。本综述还讨论了几种炎症途径,以及诱导牙髓再生的有利组织反应。M2 表型巨噬细胞的免疫调节作用是目前最被接受的方法,但由于各项研究缺乏标准化的实验程序,因此难以做出准确的决策。
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Different pulp capping agents and their effect on pulp inflammatory response: A narrative review
Several factors can directly damage dental pulp. Pulp healing requires controlled inflammation, which can be directed through specialized medical materials to eliminate infection and promote pulp repair. This review aimed to categorise these materials and identify their histological and molecular effects on pulp tissue or isolated cells in culture. In addition, we sought to identify which of these materials could trigger a favourable inflammatory pathway that could direct the pulpal response toward healing and regeneration. A single database (PubMed) was used, and the search strategy was based on MeSH terms. The search was conducted for articles published in English between January 2010 and December 2023, including those with histological and molecular findings. Only 33 articles met our inclusion criteria. Several conventional pulp capping agents have been shown to induce pulp healing and repair through dentine bridge formation. These materials show varying degrees of inflammation, ranging from moderate to mild, which may diminish over time. Other experimentally developed materials were also studied, either alone or in combination with conventional products; these materials demonstrated promising potential to reduce inflammation and superficial necrosis associated with conventional products. However, they still do not meet all the criteria for ideal pulp-capping materials and need further development for commercialisation. Several inflammatory pathways were also addressed in this review, along with favourable tissue responses to induce pulp regeneration. The immunomodulatory role of M2 phenotype macrophages is currently the most accepted, though the lack of standardised experimental procedures across studies hinder precise decision-making.
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来源期刊
Saudi Dental Journal
Saudi Dental Journal DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.60
自引率
0.00%
发文量
86
审稿时长
22 weeks
期刊介绍: Saudi Dental Journal is an English language, peer-reviewed scholarly publication in the area of dentistry. Saudi Dental Journal publishes original research and reviews on, but not limited to: • dental disease • clinical trials • dental equipment • new and experimental techniques • epidemiology and oral health • restorative dentistry • periodontology • endodontology • prosthodontics • paediatric dentistry • orthodontics and dental education Saudi Dental Journal is the official publication of the Saudi Dental Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.
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