明暗相位变化对小鼠时差适应性的不同影响

IF 8.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Journal of Pineal Research Pub Date : 2024-10-14 DOI:10.1111/jpi.13010
Changxiao Ma, Haonan Li, Bingyi Shen, Huiwen Zheng, Yunfei Chen, Lihong Chen, Guangrui Yang
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引用次数: 0

摘要

在时间生物学中,改变光/暗周期是扰乱昼夜节律的常用方法。虽然相位变换的方向和幅度(例如,+6 表示提前 6 小时换班)决定了换班前后的时间变化,但人们很少关注换班期间白天和黑夜的持续时间和相对比例,这导致昼夜节律研究中出现了一个关键的、尚未研究的变量。在这项研究中,我们引入了 "L-shift"(换班日较长的光照阶段)和 "D-shift"(较长的黑暗阶段)的概念,并研究了这些变化如何影响小鼠对时差的适应性。通过研究多种相位变换(12L 与 12D、+6L 与 +6D、-6L 与 -6D),我们证明了在对时差敏感的脂多糖诱导败血症模型中,L 移位不仅能促进更快的适应,还能显著降低败血症的严重程度。通过对间隔 1 小时(+8 至 +11)的额外相位移动进行进一步研究,证实了小鼠在 L 型移动下的适应能力得到了增强。从机理上讲,L-班制能延长睡眠时间,从而改善昼夜节律的协调,而剥夺睡眠则会使不同照明方案之间的适应性差异失效。这些发现强调了昼夜节律生物学中一个以前未被发现的因素,并表明优化照明方案可以显著提高对昼夜节律紊乱的适应性。这项研究为改进治疗策略和完善昼夜生物学领域的实验设计开辟了新途径。
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Differential Effects of Light and Dark Phase Modifications on Jet Lag Adaptability in Mice

In chronobiology, shifting light/dark cycles is a common method to disrupt circadian rhythms. While the direction and magnitude of a phase shift (e.g., +6 denoting a 6-h advanced shift) dictate the temporal change before and after the shift, little attention has been paid to the duration and relative proportion of daytime and nighttime during the shift, leading to a critical, unexamined variable in circadian research. In this study, we introduce the concepts of “L-shift” (longer light phase on the shift day) and “D-shift” (longer dark phase), and investigate how these variations impact the adaptability of mice to jet lag. By examining multiple phase shifts (12L vs. 12D, +6L vs. +6D, −6L vs. −6D), we demonstrate that L-shifts not only facilitate faster adaptation but also significantly reduce the severity of sepsis in a jet lag-sensitive lipopolysaccharide-induced sepsis model. Further investigations with additional phase shifts at 1-h intervals (+8 to +11) reinforced the enhanced fitness of mice under L-shifts. Mechanistically, L-shifts were found to increase sleep duration, thereby improving circadian entrainment, with sleep deprivation nullifying the adaptability differences between lighting protocols. These findings underscore a previously unrecognized factor in circadian biology and suggest that optimizing lighting protocols could profoundly improve adaptability to circadian disruptions. This research opens new avenues for enhancing therapeutic strategies and refining experimental designs in the field of chronobiology.

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来源期刊
Journal of Pineal Research
Journal of Pineal Research 医学-内分泌学与代谢
CiteScore
17.70
自引率
4.90%
发文量
66
审稿时长
1 months
期刊介绍: The Journal of Pineal Research welcomes original scientific research on the pineal gland and melatonin in vertebrates, as well as the biological functions of melatonin in non-vertebrates, plants, and microorganisms. Criteria for publication include scientific importance, novelty, timeliness, and clarity of presentation. The journal considers experimental data that challenge current thinking and welcomes case reports contributing to understanding the pineal gland and melatonin research. Its aim is to serve researchers in all disciplines related to the pineal gland and melatonin.
期刊最新文献
Cover image RETRACTION: Effects of Melatonin on Fatty Liver Disease: The Role of NR4A1/DNA-Pkcs/P53 Pathway, Mitochondrial Fission, and Mitophagy From Seasonality to Species Conservation: Chronobiological Research on European Hamsters in Strasbourg, France Melatonin Inhibits ET-1 Production to Break Crosstalk Between Prostate Cancer and Bone Cells: Implication for Osteoblastic Bone Metastasis Treatment Issue Information
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