心力衰竭有何新进展?2024 年 10 月

IF 16.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS European Journal of Heart Failure Pub Date : 2024-10-14 DOI:10.1002/ejhf.3492
Matthew M.Y. Lee, Pau Codina, Daniela Tomasoni, Alberto Aimo
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引用次数: 0

摘要

导言 "研究的一小步,心力衰竭治疗的一大步"--灵感来自尼尔-阿姆斯特朗本月欧洲心脏病学会会议的亮点展示了心力衰竭(HF)研究的几项突破性进展(图 1)。我们从 FINEARTS-HF 试验开始,该试验将非甾体类矿物质皮质激素受体拮抗剂 (MRA) 带到了射血分数轻度降低或保留的心力衰竭(HFmrEF/HFpEF)的治疗中。然后,我们通过 STEP-HFpEF、STEP-HFpEF DM、SELECT 和 FLOW 试验中的重要发现,探讨了胰高血糖素样肽-1 受体激动剂 (GLP-1RA) 在心房颤动中不断扩大的作用。随后,我们将介绍功能性二尖瓣反流方面的进展,以及研究二尖瓣经导管边缘到边缘修补术(M-TEER)的 RESHAPE-HF2 和 MATTERHORN 试验的结果。在心肌病领域,HELIOS-B 试验评估了治疗转甲状腺素淀粉样变性心肌病 (ATTR-CM) 的 RNA 干扰治疗剂 vutrisiran,而 SEQUOIA-HCM 和 FOREST-HCM 研究则调查了心脏肌球蛋白抑制剂 aficamten 及其在肥厚型心肌病 (HCM) 中的治疗潜力。6MWD,6 分钟步行距离;6MWT,6 分钟步行测试;ACM,全因死亡率;AF,心房颤动;AsCVD,动脉粥样硬化性心血管疾病;ATTR-CM,转甲状腺素淀粉样心肌病;CKD,慢性肾脏病;CKM,心肾代谢综合征;comp.,综合;CRP,C 反应蛋白;CV,心血管;exe、exe.,运动;FMR,功能性二尖瓣反流;HF,心力衰竭;HFH,心力衰竭住院;HFmrEF,射血分数轻度降低的心力衰竭;HFpEF,射血分数保留的心力衰竭;HFrEF,射血分数降低的心力衰竭;hs-cTnI,高敏心肌肌钙蛋白 I;inf、KCCQ-CSS,堪萨斯城心肌病临床总分;KCCQ-OS,堪萨斯城心肌病问卷调查总分;MACE,主要心血管不良事件;MRA,矿皮质激素受体拮抗剂;M-TEER,二尖瓣经导管边缘对边缘修补术;nHCM,非阻塞性肥厚型心肌病;NT-proBNP,N-末端前 B 型钠尿肽;NYHA,纽约心脏协会;oHCM,阻塞性肥厚型心肌病;SAQ-7 SS,西雅图心绞痛问卷 7 项总分;T2D,2 型糖尿病。在 BioRender 中创建,Lee, M. (2024) http://BioRender.com/m44x169
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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What's new in heart failure? October 2024
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来源期刊
European Journal of Heart Failure
European Journal of Heart Failure 医学-心血管系统
CiteScore
27.30
自引率
11.50%
发文量
365
审稿时长
1 months
期刊介绍: European Journal of Heart Failure is an international journal dedicated to advancing knowledge in the field of heart failure management. The journal publishes reviews and editorials aimed at improving understanding, prevention, investigation, and treatment of heart failure. It covers various disciplines such as molecular and cellular biology, pathology, physiology, electrophysiology, pharmacology, clinical sciences, social sciences, and population sciences. The journal welcomes submissions of manuscripts on basic, clinical, and population sciences, as well as original contributions on nursing, care of the elderly, primary care, health economics, and other related specialist fields. It is published monthly and has a readership that includes cardiologists, emergency room physicians, intensivists, internists, general physicians, cardiac nurses, diabetologists, epidemiologists, basic scientists focusing on cardiovascular research, and those working in rehabilitation. The journal is abstracted and indexed in various databases such as Academic Search, Embase, MEDLINE/PubMed, and Science Citation Index.
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