{"title":"T 细胞中的废物管理和细胞死亡","authors":"Douglas R. Green","doi":"10.1038/s41556-024-01538-0","DOIUrl":null,"url":null,"abstract":"After being activated, T lymphocytes must consume fuel for energy and biomaterials to sustain rapid proliferation and differentiation. As a consequence, waste is generated that must be managed. A new study now explores how activated CD8+ effector T cells handle ammonia, and how this impacts the survival and function of these cells.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"26 11","pages":"1826-1827"},"PeriodicalIF":17.3000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Waste management and cell death in T cells\",\"authors\":\"Douglas R. Green\",\"doi\":\"10.1038/s41556-024-01538-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"After being activated, T lymphocytes must consume fuel for energy and biomaterials to sustain rapid proliferation and differentiation. As a consequence, waste is generated that must be managed. A new study now explores how activated CD8+ effector T cells handle ammonia, and how this impacts the survival and function of these cells.\",\"PeriodicalId\":18977,\"journal\":{\"name\":\"Nature Cell Biology\",\"volume\":\"26 11\",\"pages\":\"1826-1827\"},\"PeriodicalIF\":17.3000,\"publicationDate\":\"2024-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Cell Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.nature.com/articles/s41556-024-01538-0\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41556-024-01538-0","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
T 淋巴细胞被激活后，必须消耗燃料作为能量和生物材料，以维持快速增殖和分化。因此，产生的废物必须加以管理。现在，一项新研究探讨了活化的 CD8+ 效应 T 细胞如何处理氨，以及这对这些细胞的存活和功能有何影响。
After being activated, T lymphocytes must consume fuel for energy and biomaterials to sustain rapid proliferation and differentiation. As a consequence, waste is generated that must be managed. A new study now explores how activated CD8+ effector T cells handle ammonia, and how this impacts the survival and function of these cells.
期刊介绍：
Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to:
-Autophagy
-Cancer biology
-Cell adhesion and migration
-Cell cycle and growth
-Cell death
-Chromatin and epigenetics
-Cytoskeletal dynamics
-Developmental biology
-DNA replication and repair
-Mechanisms of human disease
-Mechanobiology
-Membrane traffic and dynamics
-Metabolism
-Nuclear organization and dynamics
-Organelle biology
-Proteolysis and quality control
-RNA biology
-Signal transduction
-Stem cell biology
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
