Yi Deng, Xiaoke Lian, Zhijie Lin, Dan Sun, Haiyang Zou, Yau Kei Chan, Weizhong Yang, Miaomiao He, Guangfu Yin
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The D-BioHJzyme can catalyze the produced H<sub>2</sub>O<sub>2</sub> to highly lethal •OH with POD-mimetic activity owing to the tunned d-band center strategy decreasing the adsorption energy of the intermediate in the catalytical process, while the oxygen originated from H<sub>2</sub>O<sub>2</sub> and Mn<sup>2+</sup> can be catalyzed into <sup>1</sup>O<sub>2</sub>. The GPx-mimetic activity of it can impair the antioxidant system of tumor. In vivo studies show that the BioHJzyme exhibits robust abilities against bacteria and tumors by •OH/<sup>1</sup>O<sub>2</sub> production and promotes the apoptosis owing the Te. Besides, the BioHJzyme can accelerate cutaneous regeneration by M1/M2 regulation and the angiogenesis/collagen deposition. 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引用次数: 0
摘要
大量-OH、1O2 和-O2-的催化治疗为快速杀灭肿瘤/细菌提供了一种有效的策略和方法,但由于催化材料的内置能带,其局限性主要集中在催化效率上。因此,我们设计了 d 波段中心调谐 BioHJzyme,它由锚定葡萄糖氧化酶(GOx)的碲化锌/二氧化锰组成,具有抗肿瘤和抗菌特性,可用于肿瘤术后感染伤口的再生。葡萄糖氧化酶消耗葡萄糖产生 H2O2,阻断葡萄糖代谢。D-BioHJzyme 可将产生的 H2O2 催化为具有高度杀伤力的 -OH,具有 POD 拟态活性,这是因为调谐的 d 带中心策略降低了催化过程中中间产物的吸附能,而 H2O2 和 Mn2+ 产生的氧可被催化为 1O2。其模拟 GPx 的活性可损害肿瘤的抗氧化系统。体内研究表明,BioHJzyme通过产生-OH/1O2对细菌和肿瘤具有强大的抗击打能力,并通过Te促进细胞凋亡。此外,BioHJzyme 还能通过 M1/M2 调节和血管生成/胶原沉积加速皮肤再生。这项工作为利用工程生物HJ酶治疗肿瘤切除术后感染伤口再生提供了一个强大的平台。
Engineered Multifunctional BioHJzyme via Tuning D-Band Center for Postoperative Infected Wound Regeneration of Tumor Resection
The catalytic therapy for abundant •OH, 1O2, and •O2− provides an efficient tactic and methodology for rapid tumor/bacteria killing, whereas the limitation is focused on the catalytic efficiency owing to the in-built energy band of catalytic materials. Thus, d-band center tuning BioHJzyme is devised, which is composed of zinc tellurate/manganese dioxide anchored by glucose oxidase (GOx) with anti-tumor and anti-bacteria properties for postoperative infected wound regeneration of tumor. The GOx depletes glucose to produce H2O2, intercepting the glucose metabolism. The D-BioHJzyme can catalyze the produced H2O2 to highly lethal •OH with POD-mimetic activity owing to the tunned d-band center strategy decreasing the adsorption energy of the intermediate in the catalytical process, while the oxygen originated from H2O2 and Mn2+ can be catalyzed into 1O2. The GPx-mimetic activity of it can impair the antioxidant system of tumor. In vivo studies show that the BioHJzyme exhibits robust abilities against bacteria and tumors by •OH/1O2 production and promotes the apoptosis owing the Te. Besides, the BioHJzyme can accelerate cutaneous regeneration by M1/M2 regulation and the angiogenesis/collagen deposition. This work enlightens a powerful platform for the remedy of postoperative infected wound regeneration of tumor resection using an engineered BioHJzyme.
期刊介绍:
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