{"title":"三种健康饮食模式与体内平衡失调的关系:中国多民族队列研究的结果","authors":"","doi":"10.1016/j.jnha.2024.100394","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Homeostatic dysregulation (HD), the measure of aging-related physiological dysregulation, serves as an essential intervenable indicator of aging.</div></div><div><h3>Objective</h3><div>To explore the associations of three healthy dietary patterns with HD, investigate the most recommended dietary patterns, and identify the significant beneficial and harmful food groups</div></div><div><h3>Methods</h3><div>This prospective cohort study included 8,288 participants aged 30–79 years from the China Multi-Ethnic Cohort (CMEC), with a female majority (61.6%). Dietary information was obtained through the baseline food frequency questionnaire (FFQ). Three dietary patterns were constructed: Dietary Approaches to Stop Hypertension (DASH), alternative Mediterranean diets (aMED), and Healthy Diet Score (HDS). HD was constructed based on clinical biomarkers and anthropometric measurements. Follow-up analyses adjusted for baseline data were employed to assess the longitudinal associations of three dietary patterns at baseline with HD at follow-up. Additionally, quantile G-computation was utilized to evaluate the relative contribution of each food group to the association with HD.</div></div><div><h3>Results</h3><div>Over a follow-up period of 2.0 years, all healthy dietary patterns exhibited negative associations with HD, with <em>β</em><sub>Q5/Q1</sub> = −0.112, 95%<em>CI</em> (−0.172, −0.051) for HDS, with <em>β</em><sub>Q5/Q1</sub> = −0.073, 95%<em>CI</em> (−0.134, −0.012) for aMED, with <em>β</em><sub>Q5/Q1</sub> = −0.047, 95%<em>CI</em> (−0.107,0.014) for DASH. The results of the component analyses revealed that soybean products were the most significant beneficial food group (relative contribution of 24.0%), while alcohol was identified as the major harmful food group (relative contribution of 76.9%).</div></div><div><h3>Conclusion</h3><div>Healthy dietary patterns, especially HDS, are negatively associated with HD. Additionally, soybean products and alcohol are the most significant beneficial and detrimental food groups respectively. Developing appropriate nutritional strategies may help reduce the burden of disease and promote healthy aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Associations of three healthy dietary patterns with homeostatic dysregulation: results from the China Multi-Ethnic Cohort study\",\"authors\":\"\",\"doi\":\"10.1016/j.jnha.2024.100394\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Homeostatic dysregulation (HD), the measure of aging-related physiological dysregulation, serves as an essential intervenable indicator of aging.</div></div><div><h3>Objective</h3><div>To explore the associations of three healthy dietary patterns with HD, investigate the most recommended dietary patterns, and identify the significant beneficial and harmful food groups</div></div><div><h3>Methods</h3><div>This prospective cohort study included 8,288 participants aged 30–79 years from the China Multi-Ethnic Cohort (CMEC), with a female majority (61.6%). Dietary information was obtained through the baseline food frequency questionnaire (FFQ). Three dietary patterns were constructed: Dietary Approaches to Stop Hypertension (DASH), alternative Mediterranean diets (aMED), and Healthy Diet Score (HDS). HD was constructed based on clinical biomarkers and anthropometric measurements. Follow-up analyses adjusted for baseline data were employed to assess the longitudinal associations of three dietary patterns at baseline with HD at follow-up. Additionally, quantile G-computation was utilized to evaluate the relative contribution of each food group to the association with HD.</div></div><div><h3>Results</h3><div>Over a follow-up period of 2.0 years, all healthy dietary patterns exhibited negative associations with HD, with <em>β</em><sub>Q5/Q1</sub> = −0.112, 95%<em>CI</em> (−0.172, −0.051) for HDS, with <em>β</em><sub>Q5/Q1</sub> = −0.073, 95%<em>CI</em> (−0.134, −0.012) for aMED, with <em>β</em><sub>Q5/Q1</sub> = −0.047, 95%<em>CI</em> (−0.107,0.014) for DASH. The results of the component analyses revealed that soybean products were the most significant beneficial food group (relative contribution of 24.0%), while alcohol was identified as the major harmful food group (relative contribution of 76.9%).</div></div><div><h3>Conclusion</h3><div>Healthy dietary patterns, especially HDS, are negatively associated with HD. Additionally, soybean products and alcohol are the most significant beneficial and detrimental food groups respectively. Developing appropriate nutritional strategies may help reduce the burden of disease and promote healthy aging.</div></div>\",\"PeriodicalId\":54778,\"journal\":{\"name\":\"Journal of Nutrition Health & Aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nutrition Health & Aging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1279770724004822\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutrition Health & Aging","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1279770724004822","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景同源性失调(HD)是衡量与衰老相关的生理失调的指标,是衰老的一个重要干预指标。目的探讨三种健康膳食模式与同源性失调的关系,调查最推荐的膳食模式,并确定重要的有益和有害食物组别。方法这项前瞻性队列研究纳入了来自中国多民族队列(CMEC)的8288名30-79岁的参与者,其中女性占多数(61.6%)。膳食信息通过基线食物频率问卷(FFQ)获得。构建了三种膳食模式:高血压饮食疗法(DASH)、地中海替代饮食(aMED)和健康饮食评分(HDS)。HD 是根据临床生物标志物和人体测量数据构建的。采用调整基线数据的随访分析来评估基线时三种饮食模式与随访时 HD 的纵向关系。此外,还利用量化 G 计算来评估每种食物组别对 HD 关联性的相对贡献。结果在 2.0 年的随访期内,所有健康膳食模式均与 HD 呈负相关,其中 HDS 的 βQ5/Q1 = -0.112,95%CI (-0.172,-0.051);aMED 的 βQ5/Q1 =-0.073,95%CI (-0.134,-0.012);DASH 的 βQ5/Q1 =-0.047,95%CI (-0.107,0.014)。成分分析结果显示,大豆制品是最重要的有益食物组(相对贡献率为 24.0%),而酒精被确定为主要的有害食物组(相对贡献率为 76.9%)。此外,大豆制品和酒精分别是最主要的有益和有害食物类别。制定适当的营养策略有助于减轻疾病负担,促进健康老龄化。
Associations of three healthy dietary patterns with homeostatic dysregulation: results from the China Multi-Ethnic Cohort study
Background
Homeostatic dysregulation (HD), the measure of aging-related physiological dysregulation, serves as an essential intervenable indicator of aging.
Objective
To explore the associations of three healthy dietary patterns with HD, investigate the most recommended dietary patterns, and identify the significant beneficial and harmful food groups
Methods
This prospective cohort study included 8,288 participants aged 30–79 years from the China Multi-Ethnic Cohort (CMEC), with a female majority (61.6%). Dietary information was obtained through the baseline food frequency questionnaire (FFQ). Three dietary patterns were constructed: Dietary Approaches to Stop Hypertension (DASH), alternative Mediterranean diets (aMED), and Healthy Diet Score (HDS). HD was constructed based on clinical biomarkers and anthropometric measurements. Follow-up analyses adjusted for baseline data were employed to assess the longitudinal associations of three dietary patterns at baseline with HD at follow-up. Additionally, quantile G-computation was utilized to evaluate the relative contribution of each food group to the association with HD.
Results
Over a follow-up period of 2.0 years, all healthy dietary patterns exhibited negative associations with HD, with βQ5/Q1 = −0.112, 95%CI (−0.172, −0.051) for HDS, with βQ5/Q1 = −0.073, 95%CI (−0.134, −0.012) for aMED, with βQ5/Q1 = −0.047, 95%CI (−0.107,0.014) for DASH. The results of the component analyses revealed that soybean products were the most significant beneficial food group (relative contribution of 24.0%), while alcohol was identified as the major harmful food group (relative contribution of 76.9%).
Conclusion
Healthy dietary patterns, especially HDS, are negatively associated with HD. Additionally, soybean products and alcohol are the most significant beneficial and detrimental food groups respectively. Developing appropriate nutritional strategies may help reduce the burden of disease and promote healthy aging.
期刊介绍:
There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.