Journal of Nutrition Health & Aging最新文献

{"title":"Tackling aging muscle loss throughout lesser mealworm protein supplementation","authors":"Bruno Remigio Cavalcante , Mariana Ferreira de Souza","doi":"10.1016/j.jnha.2024.100407","DOIUrl":"10.1016/j.jnha.2024.100407","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 12","pages":"Article 100407"},"PeriodicalIF":4.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grip-Strength-Lean-Mass Index (GSLMI) as a valuable tool for sarcopenia diagnosis and survival prognosis in cancer patients: a nationwide multicenter cohort study","authors":"Zhenyu Huo ,&nbsp;Feifei Chong ,&nbsp;Siyu Luo ,&nbsp;Na Li ,&nbsp;Ning Tong ,&nbsp;Zongliang Lu ,&nbsp;Jing Guo ,&nbsp;Ling Zhang ,&nbsp;Xin Lin ,&nbsp;Mengyuan Zhang ,&nbsp;Hongmei Zhang ,&nbsp;Muli Shi ,&nbsp;Xiumei He ,&nbsp;Jie Liu ,&nbsp;Chunhua Song ,&nbsp;Hanping Shi ,&nbsp;Hongxia Xu","doi":"10.1016/j.jnha.2024.100409","DOIUrl":"10.1016/j.jnha.2024.100409","url":null,"abstract":"<div><h3>Objectives</h3><div>To identify whether the Grip-Strength-Lean-Mass Index (GSLMI) can precisely diagnose sarcopenia and predict prognosis for cancer patients in clinical settings.</div></div><div><h3>Design</h3><div>A nationwide multicenter cohort study.</div></div><div><h3>Setting and participants</h3><div>8,831 inpatients aged 18 years and older, histologically diagnosed with cancer and receiving anti-cancer therapy.</div></div><div><h3>Measurements</h3><div>The GSLMI is the ratio of hand grip strength (HGS) divided by lean mass (LM), calculated by the formula: GSLMI = HGS (kg) / LM (kg). Kaplan-Meier curves and Cox models were used to estimate the association between the GSLMI and survival.</div></div><div><h3>Results</h3><div>A total of 3,071 (48.40%) male and 3,274 (51.60%) female patients were enrolled in the study. The prevalence of GLIS-defined sarcopenia was 2,646 (41.70%). The optimal sex-specific thresholds with the best diagnostic performance to identify a low GSLMI were determined to be &lt;0.61 for males and &lt;0.47 for females based on the ROC curves. According to Kaplan-Meier curves, patients with a high GSLMI exhibited better overall survival than those with a low GSLMI (HR = 0.664, 95%CI = 0.604−0.729, log-rank P &lt; 0.001). Multivariable survival analysis revealed that the GSLMI showed an independent association with a lower hazard of death as a continuous variable (HR = 0.70, 95% CI = 0.51−0.96).</div></div><div><h3>Conclusions</h3><div>The GSLMI may serve as a novel diagnostic tool for identifying sarcopenia and may have prognostic value for cancer patients. Using the GSLMI represents a feasible and promising option for better managing the health of patients with cancer.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 1","pages":"Article 100409"},"PeriodicalIF":4.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between peak expiratory flow rate and all-cause mortality among Chinese stroke survivors","authors":"Yue-Ying Feng ,&nbsp;Conghua Wang ,&nbsp;Yuan-Mei Lan ,&nbsp;Tian-Chao Chen ,&nbsp;Hao-Qi Wu ,&nbsp;Xin-Yi Liu ,&nbsp;Xin-Juan Wu ,&nbsp;Xiao-Ming Zhang","doi":"10.1016/j.jnha.2024.100410","DOIUrl":"10.1016/j.jnha.2024.100410","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 1","pages":"Article 100410"},"PeriodicalIF":4.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial quality control measures, systemic inflammation, and lower-limb muscle power in older adults: a PROMPT secondary analysis","authors":"Helio José Coelho-Junior ,&nbsp;Emanuele Marzetti ,&nbsp;Casey L. Sexton ,&nbsp;Kevin Wu ,&nbsp;Robert Mankowski ,&nbsp;Stephen D. Anton ,&nbsp;Christiaan Leeuwenburgh ,&nbsp;Anna Picca","doi":"10.1016/j.jnha.2024.100408","DOIUrl":"10.1016/j.jnha.2024.100408","url":null,"abstract":"<div><h3>Objectives</h3><div>The study was conducted to explore associations between markers of mitochondrial quality control (MQC) from vastus lateralis muscle biopsies, serum inflammatory markers, and measures of muscle power assessed by two different tools in a sample of older adults.</div></div><div><h3>Design</h3><div>Secondary analysis of data collected in the PeppeR develOpMental ProjecT (PROMPT) at the University of Florida (Gainesville, FL, USA).</div></div><div><h3>Methods</h3><div>Forty-three older adults (n = 20 women) were included in the study. Muscle volume of the calf and thigh was quantified by three-dimensional magnetic resonance imaging. Lower-limb muscle power was estimated using 5-time sit-to-stand (5STS) muscle power equations and isokinetic test. Protein markers of MQC were measured in muscle samples by Western immoblotting (n = 12–23), while type I and II fiber cross-sectional area (CSA) and their proportion were quantified using immunohistochemistry (n = 12). Cytochrome C oxidase enzyme activity was measured spectrophotometrically. Finally, inflammatory markers were quantified in the serum using a multiplex immunoassay (n = 39).</div></div><div><h3>Results</h3><div>Mean age of participants was 78.1 ± 5.5 years, and the average body mass index was 26.2 ± 4.5 kg/m². Markers of mitochondrial biogenesis (i.e., PGC-1α), mitochondrial import proteins (i.e., cHsp70 and mtHsp70), and type I fiber CSA were significantly associated with muscle power estimated via both 5STS muscle power equations and isokinetic test (p &lt; 0.05). Specific associations were also found according to the muscle power assessment method. 5STS muscle power measures were negatively correlated with ClvCasp3, P-AMPK, T-AMPK, P-p38, GM-CSF, INF-γ, IL1b, IL6, IL8, and TNF-α, whereas positive associations were found with BAX (p &lt; 0.05). In contrast, isokinetic measures were significantly and positively correlated with RIP140, Hsp60, and type II muscle fiber CSA (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Markers of mitochondrial biogenesis (PGC-1α), mitochondrial import proteins (cHsp70 and mtHsp70), and type I muscle fiber CSA were significantly linked to lower-limb muscle power in older adults. These results suggest that muscle power is influenced by mitochondrial signaling. We also found that the relationship between mitochondrial mediators, inflammatory markers, and muscle power varied according to the assessment tool used.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 12","pages":"Article 100408"},"PeriodicalIF":4.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breakfast energy intake and dietary quality and trajectories of cardiometabolic risk factors in older adults","authors":"Karla-Alejandra Pérez-Vega ,&nbsp;Camille Lassale ,&nbsp;María-Dolores Zomeño ,&nbsp;Olga Castañer ,&nbsp;Jordi Salas-Salvadó ,&nbsp;F. Javier Basterra-Gortari ,&nbsp;Dolores Corella ,&nbsp;Ramón Estruch ,&nbsp;Emilio Ros ,&nbsp;Francisco J. Tinahones ,&nbsp;Gemma Blanchart ,&nbsp;Mireia Malcampo ,&nbsp;Daniel Muñoz-Aguayo ,&nbsp;Helmut Schröder ,&nbsp;Montserrat Fitó ,&nbsp;Álvaro Hernáez","doi":"10.1016/j.jnha.2024.100406","DOIUrl":"10.1016/j.jnha.2024.100406","url":null,"abstract":"<div><h3>Objectives</h3><div>Not skipping breakfast is associated with a better overall diet quality and lower cardiometabolic risk. However, the impact of calorie intake and dietary quality of breakfast on cardiovascular health remains unexplored. We aimed to study the associations between breakfast energy intake and quality and time trajectories of cardiometabolic traits in high cardiovascular risk participants.</div></div><div><h3>Design</h3><div>Prospective observational exploratory study with repeated measurements.</div></div><div><h3>Setting</h3><div>Spanish older adults.</div></div><div><h3>Participants</h3><div>383 participants aged 55–75 with metabolic syndrome from PREDIMED-Plus, a clinical trial involving a weight-loss lifestyle intervention based on the Mediterranean diet.</div></div><div><h3>Measurements</h3><div>Participants were followed for 36 months. Longitudinal averages of breakfast energy intake and quality were calculated. Three categories were defined for energy intake: 20−30% (reference), &lt;20% (low), and &gt;30% (high). Quality was estimated using the Meal Balance Index; categories were above (reference) or below the median score (low). Natural cubic spline mixed effects regressions described trajectories of cardiometabolic indicators (anthropometry, blood pressure, lipids, glucose, glycated hemoglobin, and kidney function) in breakfast groups. Inter-group differences in predicted values were estimated by linear regressions. Analyses were adjusted for age, sex, PREDIMED-Plus intervention group, education, smoking, physical activity, and total daily kilocalorie intake. Lipid profile analyses were further adjusted for baseline hypercholesterolemia, blood pressure analyses for baseline hypertension, and glucose/glycated hemoglobin analyses for baseline diabetes. Breakfast energy intake analyses were adjusted for breakfast quality, and vice versa.</div></div><div><h3>Results</h3><div>At 36 months, compared to the reference, low- or high-energy breakfasts were associated with differences in body mass index (low: 0.61 kg/m² [95% confidence interval: 0.19; 1.02]; high: 1.18 kg/m² [0.71; 1.65]), waist circumference (low: 2.22 cm [0.96; 3.48]; high: 4.57 cm [3.13; 6.01]), triglycerides (low: 13.8 mg/dL [10.8; 16.8]; high: 28.1 cm [24.7; 31.6]), and HDL cholesterol (low: −2.13 mg/dL [−3.41; −0.85]; high: −4.56 mg/dL [−6.04; −3.09]). At 36 months, low-quality breakfast was associated with higher waist circumference (1.50 cm [0.53; 2.46]), and triglycerides (5.81 mg/dL [3.50; 8.12]) and less HDL cholesterol (−1.66 mg/dL [−2.63; −0.69]) and estimated glomerular filtration rate (−1.22 mL/min/1.73m² [−2.02; −0.41]).</div></div><div><h3>Conclusions</h3><div>Low- or high-energy and low-quality breakfasts were associated with higher adiposity and triglycerides, and lower HDL cholesterol in high-risk older adults. Low-quality breakfasts were also linked to poorer kidney function.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 12","pages":"Article 100406"},"PeriodicalIF":4.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of phenotypic age and accelerated aging with severity and disability in patients with acute ischemic stroke","authors":"Yongkang Liu ,&nbsp;Jiangchuan Wang ,&nbsp;Zicheng Wei ,&nbsp;Yu Wang ,&nbsp;Minghua Wu ,&nbsp;Jianhua Wang ,&nbsp;Xiao Chen ,&nbsp;Rong Chen","doi":"10.1016/j.jnha.2024.100405","DOIUrl":"10.1016/j.jnha.2024.100405","url":null,"abstract":"<div><h3>Objective</h3><div>Biological age may be more accurate than chronological age in determining chronic health outcomes. However, few studies have shown the association between biological age and acute ischemic stroke (AIS). In this study we showed the association between phenotypic age (PhenoAge) or accelerated aging and severity and disability in patients with AIS.</div></div><div><h3>Design</h3><div>Retrospective study.</div></div><div><h3>Setting and subjects</h3><div>936 patients with AIS during January 2019 to July 2021 and 512 patients during June 2022 to July 2023 for a validation.</div></div><div><h3>Methods</h3><div>Stroke severity was evaluated based on the National Institute of Health stroke scale (NIHSS) questionnaire scale. Disability was evaluated by modified Rankin Scale. PhenoAge was calculated based on chronological age and 9 clinical chemistry biomarkers. Logistic regression analyses were applied to estimate the relationship between PhenoAge and the severity and disability.</div></div><div><h3>Results</h3><div>PhenoAge (odds ratio [OR] = 1.03, 95% confidence interval [CI]: 1.0–1.04, for NIHSS ≥ 5; OR = 1.05, 95%CI: 1.03−1.07, for NIHSS ≥ 10) was independently associated with stroke severity. The probability of NIHSS ≥ 5 or NIHSS ≥ 10 was significantly increased in individuals with accelerated ageing versus individuals with no accelerated aging (age gap: OR = 1.79, 95%CI: 1.18−2.72; OR = 3.53, 95%CI: 1.60−7.77; phenotypically older vs. phenotypically younger: OR = 2.01, 95%CI: 1.21−3.35; OR = 3.69, 95%CI: 1.36−10.0). Similar trends was observed when accelerated aging was defined by residual discrepancies between PhenoAge and chronological age (OR = 1.02, 95%CI: 1.01−1.04, for NIHSS ≥ 5; OR = 1.05, 95%CI: 1.02−1.08, for NIHSS ≥ 10). The area under the curve of PhenoAge was higher than that of chronological age in identifying patients with NIHSS ≥ 5 (0.66, 95%CI:0.62−0.70 vs. 0.61, 95%CI: 0.58−0.65, p &lt; 0.01) and NIHSS ≥ 10 (0.69, 95%CI:0.60−0.77 vs. 0.63, 95%CI: 0.55−0.72, p = 0.05). The probability of severe disability was significantly increased in individuals with accelerated aging versus individuals with no accelerated aging (age gap: OR = 2.87, 95%CI: 1.09−7.53; phenotypically older vs. phenotypically younger: 4.88 (1.20−19.88). Similar results were observed in the validation population.</div></div><div><h3>Conclusion</h3><div>PhenoAge or accelerated aging is associated with stroke severity and disability even after adjusting for chronological age.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 12","pages":"Article 100405"},"PeriodicalIF":4.3,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between edentulism and cardiometabolic multimorbidity in US middle-aged and older adults","authors":"Xiaoming Zhang ,&nbsp;Rui Zeng ,&nbsp;Fayi Xie ,&nbsp;Jiang Wang ,&nbsp;Dongmei Ye ,&nbsp;Aizhang Zhu ,&nbsp;Lihuan Chen ,&nbsp;Wan Zhu ,&nbsp;Ke Zhu ,&nbsp;Tenghui Fan ,&nbsp;Qingli Dou ,&nbsp;Wenwu Zhang","doi":"10.1016/j.jnha.2024.100404","DOIUrl":"10.1016/j.jnha.2024.100404","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 12","pages":"Article 100404"},"PeriodicalIF":4.3,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle function outweighs appendicular lean mass in predicting adverse outcomes: Evidence from Asian longitudinal studies","authors":"Shu Zhang,&nbsp;Li-Ning Peng ,&nbsp;Wei-Ju Lee ,&nbsp;Yukiko Nishita,&nbsp;Rei Otsuka,&nbsp;Hidenori Arai,&nbsp;Liang-Kung Chen","doi":"10.1016/j.jnha.2024.100403","DOIUrl":"10.1016/j.jnha.2024.100403","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 12","pages":"Article 100403"},"PeriodicalIF":4.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal trends of Type 2 diabetes due to low physical activity from 1990 to 2019 and forecasted prevalence in 2050: A Global Burden of Disease Study 2019","authors":"Shujin Fan ,&nbsp;Jin Xu ,&nbsp;Jinli Wu ,&nbsp;Li Yan ,&nbsp;Meng Ren","doi":"10.1016/j.jnha.2024.100402","DOIUrl":"10.1016/j.jnha.2024.100402","url":null,"abstract":"<div><h3>Background</h3><div>Type 2 diabetes mellitus (T2DM) poses a major global health burden, yet epidemiological research on low physical activity's (LPA) impact is limited. This study examines LPA's global effect on T2DM.</div></div><div><h3>Methods</h3><div>Analyzing Global Burden of Disease Database (GBD) 2019, we explored LPA-attributable T2DM deaths and Disability-Adjusted Life Years (DALYs) from 1990 to 2019, stratified by year, gender, country, and SDI regions. Estimated Annual Percentage Change (EAPC) assessed trends, and Bayesian models predicted future patterns.</div></div><div><h3>Results</h3><div>In 2019, LPA accounted for a substantial 8.5% of T2DM deaths and 6.9% of DALYs, representing a noticeable rise since 1990. Age-standardized mortality rates (ASMR) and disability-adjusted life years rates (ASDR) increased globally, particularly in low Socio-Demographic Index (SDI) regions. High and high-middle SDI regions saw a decrease in ASMR, while all regions generally saw an upward trend in ASDR. Projections for 2050 suggest a declining ASMR but an increasing ASDR, indicating a continuing burden of T2DM despite potential mortality reductions.</div></div><div><h3>Conclusion</h3><div>LPA significantly impacts T2DM, particularly in low SDI regions. Promotion of physical activity is crucial to reduce this burden, particularly in regions where the disease's impact is most severe.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 11","pages":"Article 100402"},"PeriodicalIF":4.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of oral health with geriatric syndromes and clinical outcomes in hospitalized older adults","authors":"Sheau-Wen Shyu ,&nbsp;Cheng-Fu Lin ,&nbsp;Shu-Hui Yang ,&nbsp;Wei-Min Chu ,&nbsp;Chiann-Yi Hsu ,&nbsp;Shih-Yi Lin ,&nbsp;Ya-Hui Yeh","doi":"10.1016/j.jnha.2024.100385","DOIUrl":"10.1016/j.jnha.2024.100385","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the relationship between oral health and geriatric disorders, as well as its role in clinical outcomes among acutely admitted older patients.</div></div><div><h3>Design</h3><div>A retrospective observational study was conducted.</div></div><div><h3>Setting</h3><div>The study was conducted at a medical center in central Taiwan.</div></div><div><h3>Participants</h3><div>A total of 1,141 patients (651 males and 490 females), aged 65 years or older, were admitted due to acute illness with geriatric syndromes from October 1, 2018, to March 31, 2023.</div></div><div><h3>Measurements</h3><div>A comprehensive geriatric assessment (CGA) was conducted, covering the comorbidity index, cognitive status, mood, physical function, nutritional status, mobility, health-related quality of life, frailty, and oral health condition. Oral health was evaluated using a bedside oral examination with scores ranging from 8 to 24, where scores of 8–10 indicated normal oral health, 11–14 indicated moderate impairment, and 15–24 indicated severe impairment. The primary outcome observed was in-hospital mortality.</div></div><div><h3>Results</h3><div>Among the participants, 40.5% experienced cognitive impairment, 24.8% exhibited depressive symptoms, 69.4% had low hand grip strength, 36.5% demonstrated low performance in mobility, and 78.9% were at risk of malnutrition. Severe impairment of oral health was found in 18.8% of the participants, while frailty was observed in 85.1%. Stratification of oral health severity revealed differences in various CGA parameters, including comorbidity, polypharmacy, cognitive impairment, depressive mood, physical activity, mobility, nutritional status, and quality of life, as well as clinical outcomes such as length of stay and in-hospital mortality between the groups. In univariable analysis, age, gender, frailty, oral health impairment, comorbidity index, nutritional status, and cognitive and physical functions were all significantly associated with in-hospital mortality. After adjusting for significant factors, severe oral health impairment remained significantly associated with mortality.</div></div><div><h3>Conclusion</h3><div>In acutely admitted older patients, oral health was associated with geriatric disorders and was linked to in-hospital mortality. Early intervention in oral health may be necessary to improve outcomes.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 11","pages":"Article 100385"},"PeriodicalIF":4.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}