Pub Date : 2025-03-07DOI: 10.1016/j.jnha.2025.100529
Michelle M. Mielke , Roger A. Fielding , Elizabeth J. Atkinson , Zaira Aversa , Marissa J. Schafer , Steven R. Cummings , Marco Pahor , Christiaan Leeuwenburgh , Nathan K. LeBrasseur
<div><h3>Objectives</h3><div>Cellular senescence, characterized by a marked and multifactorial senescence-associated secretory phenotype (SASP), is a potential unifying mechanism of aging and chronic disease. Most studies of the SASP have focused on frailty and other functional outcomes. Senescent cells have been detected in the brains of patients with Alzheimer’s disease, but few studies have examined associations between plasma SASP markers and cognition. The objective of this study was to examine the cross-sectional and longitudinal associations between plasma SASP markers and mild cognitive impairment among older adults at high risk of mobility disability.</div></div><div><h3>Design</h3><div>The Lifestyle Interventions for Elders (LIFE) study was a randomized controlled trial of a group-based physical activity program compared to a “successful aging” health education program to assess effects on major mobility disability that was conducted from February 2010 to December 2013.</div></div><div><h3>Setting</h3><div>Recruitment occurred at eight centers in the United States.</div></div><div><h3>Participants</h3><div>We included 1,373 participants enrolled in the study with baseline measures of 27 biomarkers of cellular senescence and adjudication of mild cognitive impairment (MCI) and dementia at baseline and 24-month follow-up. At baseline, participants were aged 70–80, sedentary, and at high risk of mobility disability.</div></div><div><h3>Measurements</h3><div>A neuropsychological assessment was administered at baseline and 24 months post-randomization. At both timepoints, a clinical adjudication committee determined whether individuals had a diagnosis of cognitively normal, MCI, or dementia; individuals with dementia at baseline were excluded. The concentrations of 26 of the 27 plasma proteins identified as components of the SASP were measured with commercially available Luminex xMAP multiplex magnetic bead-based immunoassays analyzed on the MAGPIX System while 1 protein (Activin A) was measured using an enzyme-linked immunosorbent assay.</div></div><div><h3>Results</h3><div>Logistic regression models were used to examine the associations of each senescence biomarker, in quartiles, with baseline or incident MCI. Models stratified by clinical site and adjusted for intervention assignment, age, gender, race, and education. Among 1,373 participants, 117 (8.5%) were diagnosed with MCI at baseline. Increasing quartiles of myeloperoxidase (MPO) was associated with higher odds of MCI compared to quartile 1 (Q2: OR = 1.34, 95% CI: 0.74–2.45; Q3: OR = 1.43, 95% CI: 0.80–2.59; Q4: OR = 1.79, 95% CI: 1.02–3.22). Additionally, matrix metalloproteinase 1 (MMP1) quartiles 2–4 had lower odds of MCI compared to quartile 1 (Q2: OR = 0.61, 95% CI: 0.35–1.02; Q3: OR = 0.58, 95% CI: 0.33−0.98; Q4: OR = 0.64, 95% CI: 0.37–1.08). Of the 1,256 cognitively unimpaired participants at baseline, 141 (11.2%) were diagnosed with incident MCI or dementia at the 24-month f
{"title":"Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study","authors":"Michelle M. Mielke , Roger A. Fielding , Elizabeth J. Atkinson , Zaira Aversa , Marissa J. Schafer , Steven R. Cummings , Marco Pahor , Christiaan Leeuwenburgh , Nathan K. LeBrasseur","doi":"10.1016/j.jnha.2025.100529","DOIUrl":"10.1016/j.jnha.2025.100529","url":null,"abstract":"<div><h3>Objectives</h3><div>Cellular senescence, characterized by a marked and multifactorial senescence-associated secretory phenotype (SASP), is a potential unifying mechanism of aging and chronic disease. Most studies of the SASP have focused on frailty and other functional outcomes. Senescent cells have been detected in the brains of patients with Alzheimer’s disease, but few studies have examined associations between plasma SASP markers and cognition. The objective of this study was to examine the cross-sectional and longitudinal associations between plasma SASP markers and mild cognitive impairment among older adults at high risk of mobility disability.</div></div><div><h3>Design</h3><div>The Lifestyle Interventions for Elders (LIFE) study was a randomized controlled trial of a group-based physical activity program compared to a “successful aging” health education program to assess effects on major mobility disability that was conducted from February 2010 to December 2013.</div></div><div><h3>Setting</h3><div>Recruitment occurred at eight centers in the United States.</div></div><div><h3>Participants</h3><div>We included 1,373 participants enrolled in the study with baseline measures of 27 biomarkers of cellular senescence and adjudication of mild cognitive impairment (MCI) and dementia at baseline and 24-month follow-up. At baseline, participants were aged 70–80, sedentary, and at high risk of mobility disability.</div></div><div><h3>Measurements</h3><div>A neuropsychological assessment was administered at baseline and 24 months post-randomization. At both timepoints, a clinical adjudication committee determined whether individuals had a diagnosis of cognitively normal, MCI, or dementia; individuals with dementia at baseline were excluded. The concentrations of 26 of the 27 plasma proteins identified as components of the SASP were measured with commercially available Luminex xMAP multiplex magnetic bead-based immunoassays analyzed on the MAGPIX System while 1 protein (Activin A) was measured using an enzyme-linked immunosorbent assay.</div></div><div><h3>Results</h3><div>Logistic regression models were used to examine the associations of each senescence biomarker, in quartiles, with baseline or incident MCI. Models stratified by clinical site and adjusted for intervention assignment, age, gender, race, and education. Among 1,373 participants, 117 (8.5%) were diagnosed with MCI at baseline. Increasing quartiles of myeloperoxidase (MPO) was associated with higher odds of MCI compared to quartile 1 (Q2: OR = 1.34, 95% CI: 0.74–2.45; Q3: OR = 1.43, 95% CI: 0.80–2.59; Q4: OR = 1.79, 95% CI: 1.02–3.22). Additionally, matrix metalloproteinase 1 (MMP1) quartiles 2–4 had lower odds of MCI compared to quartile 1 (Q2: OR = 0.61, 95% CI: 0.35–1.02; Q3: OR = 0.58, 95% CI: 0.33−0.98; Q4: OR = 0.64, 95% CI: 0.37–1.08). Of the 1,256 cognitively unimpaired participants at baseline, 141 (11.2%) were diagnosed with incident MCI or dementia at the 24-month f","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100529"},"PeriodicalIF":4.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-06DOI: 10.1016/j.jnha.2025.100528
Kariem Hussein , Melanie Kistler-Fischbacher , Michèle Mattle , Caroline De Godoi Rezende Costa Molino , Li-Tang Tsai , Reto W. Kressig , E. John Orav , José A.P. Da Sliva , Bruno Vellas , René Rizzoli , Gabriele Armbrecht , Egli Andreas , Bess Dawson-Hughes , Heike A. Bischoff-Ferrari , DO-HEALTH Research group
Objectives
Physical function and physical activity (PA) are key drivers of health and autonomy at older age. We examined the effects of supplemental vitamin D3, supplemental marine omega-3 fatty acids (omega-3s), and a simple home exercise program (SHEP), alone or in combination, on change in physical function and PA among generally healthy older adults.
Design
Multi-center, 2 × 2 × 2 factorial design, randomized controlled trial, follow-up of three years
Methods
Self-reported PA and physical function were pre-defined outcomes of the DO-HEALTH trial, which included older adults (≥70 years) free of major comorbidities. The interventions were vitamin D3 (2000 IU/d), marine omega-3s (1 g/d), and a SHEP (3 × 30 min/wk), applied alone or in combination in eight treatment arms. The outcomes were change in PA (self-reported total PA, metabolic equivalent [MET] h/wk) and physical function (five times sit-to-stand test, hand grip strength, gait speed) from baseline to 12, 24 and 36 months. Mixed effect models were used and adjusted for age, sex, BMI, prior fall, time and baseline level of the outcome.
Results
All 2157 DO-HEALTH participants (mean age 75 years; 83% physically active; 59% vitamin D3 replete) were included. Baseline PA was 75 MET h/wk. Participants receiving omega-3s versus no omega-3s and randomized to SHEP versus control exercise did not differ in PA change over 3 years. However, participants receiving vitamin D3 compared to those receiving no vitamin D3 (Δadjusted means: −7.1 [95% CI −12.7, −1.5] MET h/wk, P = 0.01) showed a decline in PA. Results did not differ in subgroups by sex and age (70−74 yrs, ≥75 yrs). Vitamin D3, omega-3s or SHEP did not improve physical function.
Conclusion
Among generally healthy, active, and largely vitamin D3 replete adults aged 70 years and older, vitamin D3, omega-3s and SHEP, individually and in combination had no benefits on self-reported PA and objectively measured physical function. The detrimental effect of vitamin D supplementation on PA change needs further examination.
{"title":"Effects of vitamin D3, omega-3 fatty acids and a simple home exercise program on change in physical activity among generally healthy and active older adults: The 3-year DO-HEALTH trial","authors":"Kariem Hussein , Melanie Kistler-Fischbacher , Michèle Mattle , Caroline De Godoi Rezende Costa Molino , Li-Tang Tsai , Reto W. Kressig , E. John Orav , José A.P. Da Sliva , Bruno Vellas , René Rizzoli , Gabriele Armbrecht , Egli Andreas , Bess Dawson-Hughes , Heike A. Bischoff-Ferrari , DO-HEALTH Research group","doi":"10.1016/j.jnha.2025.100528","DOIUrl":"10.1016/j.jnha.2025.100528","url":null,"abstract":"<div><h3>Objectives</h3><div>Physical function and physical activity (PA) are key drivers of health and autonomy at older age. We examined the effects of supplemental vitamin D3, supplemental marine omega-3 fatty acids (omega-3s), and a simple home exercise program (SHEP), alone or in combination, on change in physical function and PA among generally healthy older adults.</div></div><div><h3>Design</h3><div>Multi-center, 2 × 2 × 2 factorial design, randomized controlled trial, follow-up of three years</div></div><div><h3>Methods</h3><div>Self-reported PA and physical function were pre-defined outcomes of the DO-HEALTH trial, which included older adults (≥70 years) free of major comorbidities. The interventions were vitamin D3 (2000 IU/d), marine omega-3s (1 g/d), and a SHEP (3 × 30 min/wk), applied alone or in combination in eight treatment arms. The outcomes were change in PA (self-reported total PA, metabolic equivalent [MET] h/wk) and physical function (five times sit-to-stand test, hand grip strength, gait speed) from baseline to 12, 24 and 36 months. Mixed effect models were used and adjusted for age, sex, BMI, prior fall, time and baseline level of the outcome.</div></div><div><h3>Results</h3><div>All 2157 DO-HEALTH participants (mean age 75 years; 83% physically active; 59% vitamin D3 replete) were included. Baseline PA was 75 MET h/wk. Participants receiving omega-3s versus no omega-3s and randomized to SHEP versus control exercise did not differ in PA change over 3 years. However, participants receiving vitamin D3 compared to those receiving no vitamin D3 (Δadjusted means: −7.1 [95% CI −12.7, −1.5] MET h/wk, <em>P</em> = 0.01) showed a decline in PA. Results did not differ in subgroups by sex and age (70−74 yrs, ≥75 yrs). Vitamin D3, omega-3s or SHEP did not improve physical function.</div></div><div><h3>Conclusion</h3><div>Among generally healthy, active, and largely vitamin D3 replete adults aged 70 years and older, vitamin D3, omega-3s and SHEP, individually and in combination had no benefits on self-reported PA and objectively measured physical function. The detrimental effect of vitamin D supplementation on PA change needs further examination.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100528"},"PeriodicalIF":4.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-05DOI: 10.1016/j.jnha.2025.100525
Yu Huang , Shuo Wang , Le Tian , Xueli Zhang , Shunming Liu , Zhuoting Zhu , Wei Wang , Danli Shi , Mingguang He , Xianwen Shang
Objectives
This study aimed to evaluate to what extent lifestyle habits, contribute to associations between EA and various conditions, and test the variability in risk reduction for specific health conditions linked to a healthy lifestyle across different EA levels.
Design, setting, participants, and measurements
Data were analyzed from 341,632 UK Biobank participants without baseline cardiovascular disease or cancer (2006–2010). A healthy lifestyle score (0–5) was created by assigning one point for each of five habits: a healthy diet, sufficient physical activity, non-current smoking, moderate alcohol consumption, and low-risk sleep duration. Baseline data on self-reported and genotype-predicted EA were collected, with 45 health outcomes assessed until January 2021. Logistic regression models were used to assess the relationship between EA and lifestyle habits, and associations between the healthy lifestyle score and health/mortality outcomes were examined using Cox proportional hazards model. Moderation analysis tested whether EA modified the associations between a healthy lifestyle and health outcomes, while mediation analysis estimated the proportion of the association between EA and health outcomes explained by lifestyle habits.
Results
Both self-reported and genotype-predicted EA were associated with a healthy diet, non-current smoking, low-risk sleep duration, and moderate alcohol consumption, but not low-risk physical activity. A healthy lifestyle is inversely linked to risks for 38 of 45 outcomes, including CVD, type 2 diabetes, lung and colon cancer, depression, and chronic kidney disease, as well as overall, CVD, and cancer mortality. Higher EA reduced risk for 25 conditions, such as CVD, certain cancers, chronic liver disease, and fractures; stronger inverse lifestyle-risk associations were observed among less educated individuals. Lifestyle habits explained 47.2% (95% CI: 35.3–59.4%) of the association between genotype-predicted EA and all-cause mortality, mediating a large proportion of associations with CVDs, cancers, dementia, respiratory diseases, and chronic kidney disease.
Conclusions
Higher EA might encourage the adoption of more healthy lifestyle habits, thus promoting healthy aging. Placing greater emphasis on lifestyle modification is essential for individuals with lower EA to effectively address health inequalities associated with EA.
{"title":"Healthy lifestyle habits, educational attainment, and the risk of 45 age-related health and mortality outcomes in the UK: A prospective cohort study","authors":"Yu Huang , Shuo Wang , Le Tian , Xueli Zhang , Shunming Liu , Zhuoting Zhu , Wei Wang , Danli Shi , Mingguang He , Xianwen Shang","doi":"10.1016/j.jnha.2025.100525","DOIUrl":"10.1016/j.jnha.2025.100525","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate to what extent lifestyle habits, contribute to associations between EA and various conditions, and test the variability in risk reduction for specific health conditions linked to a healthy lifestyle across different EA levels.</div></div><div><h3>Design, setting, participants, and measurements</h3><div>Data were analyzed from 341,632 UK Biobank participants without baseline cardiovascular disease or cancer (2006–2010). A healthy lifestyle score (0–5) was created by assigning one point for each of five habits: a healthy diet, sufficient physical activity, non-current smoking, moderate alcohol consumption, and low-risk sleep duration. Baseline data on self-reported and genotype-predicted EA were collected, with 45 health outcomes assessed until January 2021. Logistic regression models were used to assess the relationship between EA and lifestyle habits, and associations between the healthy lifestyle score and health/mortality outcomes were examined using Cox proportional hazards model. Moderation analysis tested whether EA modified the associations between a healthy lifestyle and health outcomes, while mediation analysis estimated the proportion of the association between EA and health outcomes explained by lifestyle habits.</div></div><div><h3>Results</h3><div>Both self-reported and genotype-predicted EA were associated with a healthy diet, non-current smoking, low-risk sleep duration, and moderate alcohol consumption, but not low-risk physical activity. A healthy lifestyle is inversely linked to risks for 38 of 45 outcomes, including CVD, type 2 diabetes, lung and colon cancer, depression, and chronic kidney disease, as well as overall, CVD, and cancer mortality. Higher EA reduced risk for 25 conditions, such as CVD, certain cancers, chronic liver disease, and fractures; stronger inverse lifestyle-risk associations were observed among less educated individuals. Lifestyle habits explained 47.2% (95% CI: 35.3–59.4%) of the association between genotype-predicted EA and all-cause mortality, mediating a large proportion of associations with CVDs, cancers, dementia, respiratory diseases, and chronic kidney disease.</div></div><div><h3>Conclusions</h3><div>Higher EA might encourage the adoption of more healthy lifestyle habits, thus promoting healthy aging. Placing greater emphasis on lifestyle modification is essential for individuals with lower EA to effectively address health inequalities associated with EA.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100525"},"PeriodicalIF":4.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intrinsic capacity (IC) is vital to the World Health Organization’s healthy ageing framework. This study aims to develop an IC assessment model, and identify its longitudinal trajectories and related factors in old persons.
Methods
This was a 15-year three-wave prospective cohort study of the 10/66 dementia series researches in Beijing, China. Totally 2 156 community-dwelling old persons aged 65 years and over were included at baseline to develop an IC assessment model, with 474 completing follow-up surveys for IC trajectory identification. IC was assessed using 11 items of the five domains and bifactor-multidimensional item response theory model. The group-based trajectory model and multivariate logistic regression model were employed to identify longitudinal trajectories and related factors of IC.
Results
Three IC trajectories were identified as low baseline IC with rapid descending trajectory (11.39%), medium baseline IC with moderate descending trajectory (75.53%), and high baseline IC with slight descending trajectory (13.08%). Compared to the “slight descending trajectory”, aged 75 years and over (aOR: 9.48), female (aOR: 4.75), and unmarried/non-cohabiting (aOR: 4.73) were positively associated with the “rapid descending trajectory”. Completed secondary school/higher education (aOR: 0.08; aOR: 0.27), more vegetables/fruits intake (aOR: 0.91; aOR: 0.94), and private restricted support network (aOR: 0.17; aOR: 0.37) were negatively associated with the “rapid descending trajectory” and “moderate descending trajectory”.
Conclusions
Community-dwelling old persons in Beijing exhibit three IC trajectories, with the majority showing moderate descending trajectory. Interventions should address gender or education inequities and modifiable factors like diet and social support to mitigate IC decline.
{"title":"Trajectories of intrinsic capacity decline and related factors in old persons: A 15-year community-based cohort study in Beijing","authors":"Yuanyuan Li , Tingting Zhang , Minghui Li, Rui Shen, Xiao Wang, Chuanjun Zhuo, Ying Wang, Fang Yan, Zhaorui Liu, Yueqin Huang","doi":"10.1016/j.jnha.2025.100526","DOIUrl":"10.1016/j.jnha.2025.100526","url":null,"abstract":"<div><h3>Background</h3><div>Intrinsic capacity (IC) is vital to the World Health Organization’s healthy ageing framework. This study aims to develop an IC assessment model, and identify its longitudinal trajectories and related factors in old persons.</div></div><div><h3>Methods</h3><div>This was a 15-year three-wave prospective cohort study of the 10/66 dementia series researches in Beijing, China. Totally 2 156 community-dwelling old persons aged 65 years and over were included at baseline to develop an IC assessment model, with 474 completing follow-up surveys for IC trajectory identification. IC was assessed using 11 items of the five domains and bifactor-multidimensional item response theory model. The group-based trajectory model and multivariate logistic regression model were employed to identify longitudinal trajectories and related factors of IC.</div></div><div><h3>Results</h3><div>Three IC trajectories were identified as low baseline IC with rapid descending trajectory (11.39%), medium baseline IC with moderate descending trajectory (75.53%), and high baseline IC with slight descending trajectory (13.08%). Compared to the “slight descending trajectory”, aged 75 years and over (aOR: 9.48), female (aOR: 4.75), and unmarried/non-cohabiting (aOR: 4.73) were positively associated with the “rapid descending trajectory”. Completed secondary school/higher education (aOR: 0.08; aOR: 0.27), more vegetables/fruits intake (aOR: 0.91; aOR: 0.94), and private restricted support network (aOR: 0.17; aOR: 0.37) were negatively associated with the “rapid descending trajectory” and “moderate descending trajectory”.</div></div><div><h3>Conclusions</h3><div>Community-dwelling old persons in Beijing exhibit three IC trajectories, with the majority showing moderate descending trajectory. Interventions should address gender or education inequities and modifiable factors like diet and social support to mitigate IC decline.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100526"},"PeriodicalIF":4.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-03DOI: 10.1016/j.jnha.2025.100524
Grace Cheong , William Tov , Robin Wai Munn Choo , Micah Tan , Lay Khoon Lau , Wee Shiong Lim , Yew Yoong Ding , Paulin Tay Straughan
Objective
The World Health Organization has identified intrinsic capacity and functional ability as key constructs in enabling healthy ageing. However, functional ability is distinct from actual levels of social and physical participation, which research has shown to be associated with health and wellbeing. This study distinguishes between functional ability and actual levels of social and physical participation, and utilizes the International Classification of Functioning, Disability and Health framework to examine the relationship between IC and the two constructs.
Methods
This study utilizes cross-sectional self-reported data from a nationally representative panel of Singapore residents aged 56–75 (N = 6,434). We performed structural equation modelling to compare the direct and indirect effects (mediated by IADLs) of intrinsic capacity on social participation. Intrinsic capacity is modelled as a second-order model, and its 5 domains are assessed using self-reported indicators. IADLs was based on participants’ self-reported difficulty in completing 7 instrumental daily activities. Social participation was measured using participants’ frequency of engagement in various activities.
Results
Intrinsic capacity is positively associated with higher levels of social participation among middle-aged and older adults aged 56–75 (β = 0.287, 95% CI [0.156, 0.414]) even after controlling for IADLs. The direct effect of intrinsic capacity on social participation accounts for 77.4 % of the total effect, while the indirect effect through IADLs accounts for 22.6% of the total effect.
Conclusion
Intrinsic capacity is associated with social and physical participation directly and indirectly through IADLs. This study emphasizes the need for healthcare interventions aimed towards the promotion of healthy ageing to adopt a holistic approach that enhance IC across its five domains, ensuring both social and physical participation and functional independence of older adults.
{"title":"Exploring the relationship between intrinsic capacity and social participation in healthy ageing: Evidence from Singapore","authors":"Grace Cheong , William Tov , Robin Wai Munn Choo , Micah Tan , Lay Khoon Lau , Wee Shiong Lim , Yew Yoong Ding , Paulin Tay Straughan","doi":"10.1016/j.jnha.2025.100524","DOIUrl":"10.1016/j.jnha.2025.100524","url":null,"abstract":"<div><h3>Objective</h3><div>The World Health Organization has identified intrinsic capacity and functional ability as key constructs in enabling healthy ageing. However, functional ability is distinct from actual levels of social and physical participation, which research has shown to be associated with health and wellbeing. This study distinguishes between functional ability and actual levels of social and physical participation, and utilizes the International Classification of Functioning, Disability and Health framework to examine the relationship between IC and the two constructs.</div></div><div><h3>Methods</h3><div>This study utilizes cross-sectional self-reported data from a nationally representative panel of Singapore residents aged 56–75 (N = 6,434). We performed structural equation modelling to compare the direct and indirect effects (mediated by IADLs) of intrinsic capacity on social participation. Intrinsic capacity is modelled as a second-order model, and its 5 domains are assessed using self-reported indicators. IADLs was based on participants’ self-reported difficulty in completing 7 instrumental daily activities. Social participation was measured using participants’ frequency of engagement in various activities.</div></div><div><h3>Results</h3><div>Intrinsic capacity is positively associated with higher levels of social participation among middle-aged and older adults aged 56–75 (β = 0.287, 95% CI [0.156, 0.414]) even after controlling for IADLs. The direct effect of intrinsic capacity on social participation accounts for 77.4 % of the total effect, while the indirect effect through IADLs accounts for 22.6% of the total effect.</div></div><div><h3>Conclusion</h3><div>Intrinsic capacity is associated with social and physical participation directly and indirectly through IADLs. This study emphasizes the need for healthcare interventions aimed towards the promotion of healthy ageing to adopt a holistic approach that enhance IC across its five domains, ensuring both social and physical participation and functional independence of older adults.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100524"},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-25DOI: 10.1016/j.jnha.2025.100523
Luying Qiu
{"title":"Letter to the editor on:” Association between pain, sleep and intrinsic capacity in Chinese older adults: Evidence from CHARLS”","authors":"Luying Qiu","doi":"10.1016/j.jnha.2025.100523","DOIUrl":"10.1016/j.jnha.2025.100523","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100523"},"PeriodicalIF":4.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-21DOI: 10.1016/j.jnha.2025.100522
Yingying Zhang , Zhina Gong , Jianzheng Cai , Weixia Yu , Yinuo Dai , Haifang Wang
Objective
Dysphagia-related safety incidents encompass near-miss events, no-harm occurrences, or harmful incidents associated with oral or enteral feeding methods. This systematic review and meta-analysis aimed to assess the incidence rates of dysphagia-related safety incidents in older adults across various feeding methods.
Methods
A comprehensive literature search was conducted using PubMed, Embase, Web of Science, Cochrane Library, and CINAHL databases to identify studies reporting dysphagia-related safety incidents in older adults. The feeding methods analyzed included oral feeding, nasogastric (NG) tube feeding, and percutaneous endoscopic gastrostomy (PEG) tube feeding. Randomized controlled trials (RCTs), non-randomized studies, and cohort studies were included. The analysis adhered to the PRISMA guidelines, and meta-analytic outcomes were presented with 95% confidence intervals (CIs).
Results
A total of 30 studies satisfied the inclusion criteria. The overall incidence rates of safety incidents were 13.8% for oral feeding, 23.9% for NG tube feeding, and 26.5% for PEG tube feeding. Aspiration pneumonia emerged as the most prevalent safety incident across all feeding methods, with incidence rates of 12.0% for oral feeding, 20.6% for NG tube feeding, and 12.4% for PEG tube feeding. Tube feeding methods were associated with diarrhea and wound infection. Additionally, specialized safety incidents were observed for each feeding method: suffocation in oral feeding; gastroesophageal reflux in NG tube feeding; and tube blockage, tube dislodgment, tube leakage, vomiting, nausea, site pain, gastrointestinal hemorrhage, and peritonitis in PEG tube feeding.
Conclusions
Dysphagia-related safety incidents in older adults demonstrated considerable variability in type and frequency across different feeding methods. Understanding these differences could provide healthcare professionals with valuable insights for targeted risk prediction and proactive management strategies to mitigate such incidents.
{"title":"Incidence of dysphagia-related safety incidents in older adults across feeding methods: A systematic review and meta-analysis","authors":"Yingying Zhang , Zhina Gong , Jianzheng Cai , Weixia Yu , Yinuo Dai , Haifang Wang","doi":"10.1016/j.jnha.2025.100522","DOIUrl":"10.1016/j.jnha.2025.100522","url":null,"abstract":"<div><h3>Objective</h3><div>Dysphagia-related safety incidents encompass near-miss events, no-harm occurrences, or harmful incidents associated with oral or enteral feeding methods. This systematic review and meta-analysis aimed to assess the incidence rates of dysphagia-related safety incidents in older adults across various feeding methods.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted using PubMed, Embase, Web of Science, Cochrane Library, and CINAHL databases to identify studies reporting dysphagia-related safety incidents in older adults. The feeding methods analyzed included oral feeding, nasogastric (NG) tube feeding, and percutaneous endoscopic gastrostomy (PEG) tube feeding. Randomized controlled trials (RCTs), non-randomized studies, and cohort studies were included. The analysis adhered to the PRISMA guidelines, and meta-analytic outcomes were presented with 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>A total of 30 studies satisfied the inclusion criteria. The overall incidence rates of safety incidents were 13.8% for oral feeding, 23.9% for NG tube feeding, and 26.5% for PEG tube feeding. Aspiration pneumonia emerged as the most prevalent safety incident across all feeding methods, with incidence rates of 12.0% for oral feeding, 20.6% for NG tube feeding, and 12.4% for PEG tube feeding. Tube feeding methods were associated with diarrhea and wound infection. Additionally, specialized safety incidents were observed for each feeding method: suffocation in oral feeding; gastroesophageal reflux in NG tube feeding; and tube blockage, tube dislodgment, tube leakage, vomiting, nausea, site pain, gastrointestinal hemorrhage, and peritonitis in PEG tube feeding.</div></div><div><h3>Conclusions</h3><div>Dysphagia-related safety incidents in older adults demonstrated considerable variability in type and frequency across different feeding methods. Understanding these differences could provide healthcare professionals with valuable insights for targeted risk prediction and proactive management strategies to mitigate such incidents.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100522"},"PeriodicalIF":4.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-21DOI: 10.1016/j.jnha.2025.100520
Haoxian Tang , Xuan Zhang , Nan Luo , Jingtao Huang , Qinglong Yang , Hanyuan Lin , Mengyue Lin , Shiwan Wu , Jiasheng Wen , Jianan Hong , Pan Chen , Liwen Jiang , Yequn Chen , Xuerui Tan
Background
Diet plays a critical role in human health and environmental sustainability, particularly in cardiovascular, kidney, and metabolic (CKM) diseases. However, the variations in the Planetary Health Diet Index (PHDI) across populations, regions, and over time, as well as its association with CKM disease burdens, remain insufficiently explored.
Methods
We assessed PHDI scores using data from 185 countries (1990–2018) from the Global Dietary Database, examining demographic characteristics and temporal trends. The Global Burden of Disease Study was used to evaluate the associations between PHDI and CKM disease burdens, including incidence, prevalence, mortality, and disability-adjusted life years. CKM syndrome was defined by the American Heart Association. Individual-level data from the National Health and Nutrition Examination Survey (NHANES) were also used to assess the impact of PHDI on CKM risks and mortality.
Results
From 1990 to 2018, while overall PHDI scores remained relatively stable between sexes, the composition of PHDI scores shifted across different age groups. In 2018, the mean PHDI score was 42.80 (95% uncertainty interval [UI] 42.49–46.50) for males and 44.65 (95% UI 44.53–47.82) for females. Higher PHDI scores were observed among females, older adults, urban residents, individuals with higher education, and those from South Asia. Globally, consumption of red/processed meat, saturated oils/trans fats, and added sugars substantially exceeded the EAT-Lancet Commission’s reference values. Higher PHDI scores were generally associated with lower CKM disease burdens, although these associations varied by disease subtype. In individual-level analysis, including 45,460 NHANES participants (weighted mean age: 47.21 years, 51.4% female), each 10-point increase in PHDI was linked to a 13.7% reduction in stage 3/4 CKM syndrome risk, an 11.1% reduction in stage 4 CKM syndrome risk, and lower incidences and mortality rates for cardiovascular diseases, metabolic diseases, and chronic kidney disease.
Conclusions
From 1990 to 2018, significant changes occurred in the components of the PHDI, with notable variations by demographics and region. Higher PHDI scores may reduce CKM disease burdens, warranting further investigation into specific disease subtypes.
{"title":"Temporal trends in the planetary health diet index and its association with cardiovascular, kidney, and metabolic diseases: A comprehensive analysis from global and individual perspectives","authors":"Haoxian Tang , Xuan Zhang , Nan Luo , Jingtao Huang , Qinglong Yang , Hanyuan Lin , Mengyue Lin , Shiwan Wu , Jiasheng Wen , Jianan Hong , Pan Chen , Liwen Jiang , Yequn Chen , Xuerui Tan","doi":"10.1016/j.jnha.2025.100520","DOIUrl":"10.1016/j.jnha.2025.100520","url":null,"abstract":"<div><h3>Background</h3><div>Diet plays a critical role in human health and environmental sustainability, particularly in cardiovascular, kidney, and metabolic (CKM) diseases. However, the variations in the Planetary Health Diet Index (PHDI) across populations, regions, and over time, as well as its association with CKM disease burdens, remain insufficiently explored.</div></div><div><h3>Methods</h3><div>We assessed PHDI scores using data from 185 countries (1990–2018) from the Global Dietary Database, examining demographic characteristics and temporal trends. The Global Burden of Disease Study was used to evaluate the associations between PHDI and CKM disease burdens, including incidence, prevalence, mortality, and disability-adjusted life years. CKM syndrome was defined by the American Heart Association. Individual-level data from the National Health and Nutrition Examination Survey (NHANES) were also used to assess the impact of PHDI on CKM risks and mortality.</div></div><div><h3>Results</h3><div>From 1990 to 2018, while overall PHDI scores remained relatively stable between sexes, the composition of PHDI scores shifted across different age groups. In 2018, the mean PHDI score was 42.80 (95% uncertainty interval [UI] 42.49–46.50) for males and 44.65 (95% UI 44.53–47.82) for females. Higher PHDI scores were observed among females, older adults, urban residents, individuals with higher education, and those from South Asia. Globally, consumption of red/processed meat, saturated oils/trans fats, and added sugars substantially exceeded the EAT-Lancet Commission’s reference values. Higher PHDI scores were generally associated with lower CKM disease burdens, although these associations varied by disease subtype. In individual-level analysis, including 45,460 NHANES participants (weighted mean age: 47.21 years, 51.4% female), each 10-point increase in PHDI was linked to a 13.7% reduction in stage 3/4 CKM syndrome risk, an 11.1% reduction in stage 4 CKM syndrome risk, and lower incidences and mortality rates for cardiovascular diseases, metabolic diseases, and chronic kidney disease.</div></div><div><h3>Conclusions</h3><div>From 1990 to 2018, significant changes occurred in the components of the PHDI, with notable variations by demographics and region. Higher PHDI scores may reduce CKM disease burdens, warranting further investigation into specific disease subtypes.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100520"},"PeriodicalIF":4.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-20DOI: 10.1016/j.jnha.2025.100519
Yu-Shan Lee , Yukiko Nishita , Chikako Tange , Shu Zhang , Hiroshi Shimokata , Shih-Yi Lin , Wei-Min Chu , Rei Ostuka
Background
Frailty transition is common, and increased physical activity can prevent it. An objective assessment of physical activity could eliminate bias and provide more precise information on the association between frailty transitions and physical activity.
Objectives
This study aimed to examine the association between objective physical activity and frailty transition in community-dwelling prefrail Japanese older adults.
Design
This is a retrospective cohort study based on the National Institute for Longevity Science-Longitudinal Study of Aging data.
Participants
A total of 387 community-dwelling older adults with prefrailty were enrolled (mean age 72.0 years).
Measurements
Frailty was assessed using modified components of the Cardiovascular Health Study criteria, and frailty statuses were reassessed two years later. The frailty transitions were categorized into three groups: deterioration, persistence, and reversal. Participants wore a uniaxial accelerometer to assess the physical activities. Differences in baseline characteristics according to frailty transitions were assessed. To compare the baseline objective physical activities based on frailty transition, a general linear model and a logistic regression model were used.
Results
Among the 387 participants, 40 (10.3%) deteriorated to frailty, 97 (25.0%) reversed to robust, and the majority (n = 250, 64.6%) remained prefrail after a 2-year follow-up. Using the general linear model, after adjusting for other factors, total energy expenditure (TEE) in the reversal group was significantly higher than that in the deterioration and persistence groups. No differences in TEE were observed between the persistence and deterioration groups. No significant differences existed in the numbers of daily steps, exercise energy expenditure (EEE) and physical activity with different intensity among these three groups. The logistic model also showed a significant association between TEE and the reversal of frailty.
Conclusion
Frailty transitions were common in the Japanese prefrail population. This study showed that a higher TEE was positively associated with frailty reversal in prefrail older adults. Promoting proactive programs for older adults to increase physical activity could help them stay healthy and prevent frailty deterioration.
{"title":"Association between objective physical activity and frailty transition in community-dwelling prefrail Japanese older adults","authors":"Yu-Shan Lee , Yukiko Nishita , Chikako Tange , Shu Zhang , Hiroshi Shimokata , Shih-Yi Lin , Wei-Min Chu , Rei Ostuka","doi":"10.1016/j.jnha.2025.100519","DOIUrl":"10.1016/j.jnha.2025.100519","url":null,"abstract":"<div><h3>Background</h3><div>Frailty transition is common, and increased physical activity can prevent it. An objective assessment of physical activity could eliminate bias and provide more precise information on the association between frailty transitions and physical activity.</div></div><div><h3>Objectives</h3><div>This study aimed to examine the association between objective physical activity and frailty transition in community-dwelling prefrail Japanese older adults.</div></div><div><h3>Design</h3><div>This is a retrospective cohort study based on the National Institute for Longevity Science-Longitudinal Study of Aging data.</div></div><div><h3>Participants</h3><div>A total of 387 community-dwelling older adults with prefrailty were enrolled (mean age 72.0 years).</div></div><div><h3>Measurements</h3><div>Frailty was assessed using modified components of the Cardiovascular Health Study criteria, and frailty statuses were reassessed two years later. The frailty transitions were categorized into three groups: deterioration, persistence, and reversal. Participants wore a uniaxial accelerometer to assess the physical activities. Differences in baseline characteristics according to frailty transitions were assessed. To compare the baseline objective physical activities based on frailty transition, a general linear model and a logistic regression model were used.</div></div><div><h3>Results</h3><div>Among the 387 participants, 40 (10.3%) deteriorated to frailty, 97 (25.0%) reversed to robust, and the majority (<em>n</em> = 250, 64.6%) remained prefrail after a 2-year follow-up. Using the general linear model, after adjusting for other factors, total energy expenditure (TEE) in the reversal group was significantly higher than that in the deterioration and persistence groups. No differences in TEE were observed between the persistence and deterioration groups. No significant differences existed in the numbers of daily steps, exercise energy expenditure (EEE) and physical activity with different intensity among these three groups. The logistic model also showed a significant association between TEE and the reversal of frailty.</div></div><div><h3>Conclusion</h3><div>Frailty transitions were common in the Japanese prefrail population. This study showed that a higher TEE was positively associated with frailty reversal in prefrail older adults. Promoting proactive programs for older adults to increase physical activity could help them stay healthy and prevent frailty deterioration.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100519"},"PeriodicalIF":4.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-20DOI: 10.1016/j.jnha.2025.100521
Beom-Jun Kim , Yunju Jo , Ji Yeon Baek , So Jeong Park , Hee-Won Jung , Eunju Lee , Il-Young Jang , Hyuk Sakong , Dongryeol Ryu
Background
Despite the pleiotropic role of resistin as an adipokine, its association with frailty—an indicator of biologic age and overall well-being in humans—remains largely unexplored. This study aims to investigate the potential of circulating resistin as a biomarker for frailty.
Methods
The study included 228 older adults aged 65 years or older who underwent a comprehensive geriatric assessment. Frailty was evaluated using both the phenotypic frailty model by Fried and the deficit-accumulation frailty index (FI) by Rockwood. Serum resistin levels were measured using a competitive enzyme-linked immunosorbent assay.
Results
After adjusting for sex, age, body mass index, smoking, alcohol, exercise, diabetes, and serum creatinine, serum resistin levels were 52.2% higher in individuals with phenotypic frailty than in robust controls (P = 0.001) and showed a positive correlation with the Rockwood FI (P = 0.015). Furthermore, for every 1 standard deviation increase in serum resistin levels, the risk of frailty increased by 67% (P = 0.021). When participants were divided into four groups based on serum resistin levels, individuals in the highest quartile had a 38% higher FI and exhibited a 12.5-fold higher odds ratio for frailty compared to those in the lowest quartile (P = 0.016 and 0.024, respectively).
Conclusion
These findings suggest that circulating resistin may serve as a candidate blood-based biomarker for frailty, encompassing the multifaceted physical, cognitive, and social dimensions, extending beyond its well-established role in metabolic regulation.
{"title":"Higher serum resistin levels and increased frailty risk in older adults: Implications beyond metabolic function","authors":"Beom-Jun Kim , Yunju Jo , Ji Yeon Baek , So Jeong Park , Hee-Won Jung , Eunju Lee , Il-Young Jang , Hyuk Sakong , Dongryeol Ryu","doi":"10.1016/j.jnha.2025.100521","DOIUrl":"10.1016/j.jnha.2025.100521","url":null,"abstract":"<div><h3>Background</h3><div>Despite the pleiotropic role of resistin as an adipokine, its association with frailty—an indicator of biologic age and overall well-being in humans—remains largely unexplored. This study aims to investigate the potential of circulating resistin as a biomarker for frailty.</div></div><div><h3>Methods</h3><div>The study included 228 older adults aged 65 years or older who underwent a comprehensive geriatric assessment. Frailty was evaluated using both the phenotypic frailty model by Fried and the deficit-accumulation frailty index (FI) by Rockwood. Serum resistin levels were measured using a competitive enzyme-linked immunosorbent assay.</div></div><div><h3>Results</h3><div>After adjusting for sex, age, body mass index, smoking, alcohol, exercise, diabetes, and serum creatinine, serum resistin levels were 52.2% higher in individuals with phenotypic frailty than in robust controls (<em>P</em> = 0.001) and showed a positive correlation with the Rockwood FI (<em>P</em> = 0.015). Furthermore, for every 1 standard deviation increase in serum resistin levels, the risk of frailty increased by 67% (<em>P</em> = 0.021). When participants were divided into four groups based on serum resistin levels, individuals in the highest quartile had a 38% higher FI and exhibited a 12.5-fold higher odds ratio for frailty compared to those in the lowest quartile (<em>P</em> = 0.016 and 0.024, respectively).</div></div><div><h3>Conclusion</h3><div>These findings suggest that circulating resistin may serve as a candidate blood-based biomarker for frailty, encompassing the multifaceted physical, cognitive, and social dimensions, extending beyond its well-established role in metabolic regulation.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100521"},"PeriodicalIF":4.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：