门德尔随机化--有哪些承诺？

IF 6.1 2区医学 Q1 CLINICAL NEUROLOGY European Neuropsychopharmacology Pub Date : 2024-10-01 DOI:10.1016/j.euroneuro.2024.08.028

Sibylle Schwab (Chair) , Naomi Wray (Co-chair and Discussant)

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引用次数: 0

摘要

随着针对各种表型的全基因组关联分析提供了足够多的数据，一种名为 "孟德尔随机化"（Mendelian Randomization）的技术已成为寻找因果关系的常用方法。从本质上讲，这种技术使用遗传因素作为可改变暴露的替代物来探索因果关系。要进行有效且有影响的孟德尔随机化估计，需要满足几个条件。在本次研讨会上，我们将更详细地探讨这些条件，并举例说明精神遗传学中的一些有意义的探索。

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MENDELIAN RANDOMIZATION – WHAT ARE THE PROMISES?

With the availability of sufficiently large data from genome wide association analyses for varied phenotypes, a technique, Mendelian Randomization, has become common when searching for causal factors. Essentially, this technique uses genetic factors as proxies for modifiable exposures to explore causal relationships. There are several conditions, which are required for a valid andimpactful Mendelian Randomization estimation. In this symposium, we explore these conditions in more detail, in addition to providing some examples for meaningful explorations in psychiatric genetics.

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来源期刊

European Neuropsychopharmacology 医学-精神病学

CiteScore

10.30

自引率

5.40%

发文量

730

审稿时长

41 days

期刊介绍： European Neuropsychopharmacology is the official publication of the European College of Neuropsychopharmacology (ECNP). In accordance with the mission of the College, the journal focuses on clinical and basic science contributions that advance our understanding of brain function and human behaviour and enable translation into improved treatments and enhanced public health impact in psychiatry. Recent years have been characterized by exciting advances in basic knowledge and available experimental techniques in neuroscience and genomics. However, clinical translation of these findings has not been as rapid. The journal aims to narrow this gap by promoting findings that are expected to have a major impact on both our understanding of the biological bases of mental disorders and the development and improvement of treatments, ideally paving the way for prevention and recovery.