药物折纸:计算指导下的口服制剂药物释放动力学定制方法

IF 17.3 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Matter Pub Date : 2025-01-08 DOI:10.1016/j.matt.2024.09.022
Hao Huang , Haoyu Zhang , Ningjie Du , Yidan Lyu , Jiahang Xu , Haoran Fu , Yixin Guan , Kewang Nan
{"title":"药物折纸:计算指导下的口服制剂药物释放动力学定制方法","authors":"Hao Huang ,&nbsp;Haoyu Zhang ,&nbsp;Ningjie Du ,&nbsp;Yidan Lyu ,&nbsp;Jiahang Xu ,&nbsp;Haoran Fu ,&nbsp;Yixin Guan ,&nbsp;Kewang Nan","doi":"10.1016/j.matt.2024.09.022","DOIUrl":null,"url":null,"abstract":"<div><div>Despite the prolonged therapeutic benefits offered by many existing extended-release oral drug formulations, their inability to conform to circadian rhythms and specific pathological profiles remains a critical limitation. Here, we report drug origami, a computation-guided, origami-inspired approach for modulating the drug release kinetics of oral formulations. By harnessing the precise folding patterns of origami, the drug origami demonstrates characteristics of pulsatile and multiphasic release that can be tailored to match specific medication regimens. By employing computational models guided by control equations, both <em>in vitro</em> and <em>in vivo</em> drug release kinetics can be predicted and modulated with good quantitative agreement. This and other evidence suggest drug origami to be “do-it-yourself” drugs in personalized medicine where patients can create their own formulations according to individual medical needs.</div></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"8 1","pages":"Article 101878"},"PeriodicalIF":17.3000,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Drug origami: A computation-guided approach for customizable drug release kinetics of oral formulations\",\"authors\":\"Hao Huang ,&nbsp;Haoyu Zhang ,&nbsp;Ningjie Du ,&nbsp;Yidan Lyu ,&nbsp;Jiahang Xu ,&nbsp;Haoran Fu ,&nbsp;Yixin Guan ,&nbsp;Kewang Nan\",\"doi\":\"10.1016/j.matt.2024.09.022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Despite the prolonged therapeutic benefits offered by many existing extended-release oral drug formulations, their inability to conform to circadian rhythms and specific pathological profiles remains a critical limitation. Here, we report drug origami, a computation-guided, origami-inspired approach for modulating the drug release kinetics of oral formulations. By harnessing the precise folding patterns of origami, the drug origami demonstrates characteristics of pulsatile and multiphasic release that can be tailored to match specific medication regimens. By employing computational models guided by control equations, both <em>in vitro</em> and <em>in vivo</em> drug release kinetics can be predicted and modulated with good quantitative agreement. This and other evidence suggest drug origami to be “do-it-yourself” drugs in personalized medicine where patients can create their own formulations according to individual medical needs.</div></div>\",\"PeriodicalId\":388,\"journal\":{\"name\":\"Matter\",\"volume\":\"8 1\",\"pages\":\"Article 101878\"},\"PeriodicalIF\":17.3000,\"publicationDate\":\"2025-01-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Matter\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590238524005010\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Matter","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590238524005010","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

尽管许多现有的缓释口服药物制剂具有延长治疗时间的优点,但它们无法适应昼夜节律和特定病理特征仍然是一个关键的限制因素。在此,我们报告了药物折纸,这是一种由计算引导、受折纸启发的调节口服制剂药物释放动力学的方法。通过利用折纸的精确折叠模式,药物折纸显示出脉冲式和多相释放的特点,可根据特定的用药方案进行定制。通过采用以控制方程为指导的计算模型,体外和体内药物释放动力学均可预测和调控,并具有良好的定量一致性。这和其他证据表明,药物折纸是个性化医疗中的 "自己动手 "药物,患者可以根据个人医疗需求创造自己的配方。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Drug origami: A computation-guided approach for customizable drug release kinetics of oral formulations
Despite the prolonged therapeutic benefits offered by many existing extended-release oral drug formulations, their inability to conform to circadian rhythms and specific pathological profiles remains a critical limitation. Here, we report drug origami, a computation-guided, origami-inspired approach for modulating the drug release kinetics of oral formulations. By harnessing the precise folding patterns of origami, the drug origami demonstrates characteristics of pulsatile and multiphasic release that can be tailored to match specific medication regimens. By employing computational models guided by control equations, both in vitro and in vivo drug release kinetics can be predicted and modulated with good quantitative agreement. This and other evidence suggest drug origami to be “do-it-yourself” drugs in personalized medicine where patients can create their own formulations according to individual medical needs.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
相关文献
二甲双胍通过HDAC6和FoxO3a转录调控肌肉生长抑制素诱导肌肉萎缩
IF 8.9 1区 医学Journal of Cachexia, Sarcopenia and MusclePub Date : 2021-11-02 DOI: 10.1002/jcsm.12833
Min Ju Kang, Ji Wook Moon, Jung Ok Lee, Ji Hae Kim, Eun Jeong Jung, Su Jin Kim, Joo Yeon Oh, Sang Woo Wu, Pu Reum Lee, Sun Hwa Park, Hyeon Soo Kim
具有疾病敏感单倍型的非亲属供体脐带血移植后的1型糖尿病
IF 3.2 3区 医学Journal of Diabetes InvestigationPub Date : 2022-11-02 DOI: 10.1111/jdi.13939
Kensuke Matsumoto, Taisuke Matsuyama, Ritsu Sumiyoshi, Matsuo Takuji, Tadashi Yamamoto, Ryosuke Shirasaki, Haruko Tashiro
封面:蛋白质组学分析确定IRSp53和fastin是PRV输出和直接细胞-细胞传播的关键
IF 3.4 4区 生物学ProteomicsPub Date : 2019-12-02 DOI: 10.1002/pmic.201970201
Fei-Long Yu, Huan Miao, Jinjin Xia, Fan Jia, Huadong Wang, Fuqiang Xu, Lin Guo
来源期刊
Matter
Matter MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
26.30
自引率
2.60%
发文量
367
期刊介绍: Matter, a monthly journal affiliated with Cell, spans the broad field of materials science from nano to macro levels,covering fundamentals to applications. Embracing groundbreaking technologies,it includes full-length research articles,reviews, perspectives,previews, opinions, personnel stories, and general editorial content. Matter aims to be the primary resource for researchers in academia and industry, inspiring the next generation of materials scientists.
期刊最新文献
Sub-nm kinetically controlled liquid metal printing of ternary antimony indium oxide transistors Lattice distortion boosted exceptional electromagnetic wave absorption in high-entropy diborides Open-air spray deposition of PCBM/BCP electron transport layer for inverted perovskite solar cells Sustainable conversion of husk into viscoelastic hydrogels for value-added biomedical applications Exploring the soft cradle effect and ionic transport mechanisms in the LiMXCl4 superionic conductor family
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1